DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
PTSTT
Uniprot ID:
Q2M2H8
Source protein:
Probable maltase-glucoamylase 2
Source gene:
MGAM2
Class:
DEG_SPOP_SBC_1
Location:
1885:1889
E3 ligase:
SPOP
DEGRON score:
0.9877
ASA_SCORE:
82.22
COIL:
0.9212
CONS_SCORE:
0
DSS_SCORE:
0.5623
HELIX:
0.0344
FCONS_SCORE:
0
RIG_SCORE:
0.7086
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MGAM2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTSTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75175
CCR4-NOT transcription complex subunit 3
DEG_SPOP_SBC_1
261:265
PTSTT
SPOP
0.9957
More...
O95274
Ly6/PLAUR domain-containing protein 3
DEG_SPOP_SBC_1
265:269
PTSTT
SPOP
0.6057
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
1269:1273
PTSTT
SPOP
0.8061
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
3449:3453
PTSTT
SPOP
0.9952
More...
Q6W4X9
Mucin-6
DEG_SPOP_SBC_1
1539:1543
PTSTT
SPOP
0.9933
More...
Q6W4X9
Mucin-6
DEG_SPOP_SBC_1
1932:1936
PTSTT
SPOP
0.7189
More...
Q8IZF6
Adhesion G-protein coupled receptor G4
DEG_SPOP_SBC_1
638:642
PTSTT
SPOP
0.5747
More...
Q8NFY4
Semaphorin-6D
DEG_SPOP_SBC_1
573:577
PTSTT
SPOP
0.9915
More...
Q92954
Proteoglycan 4
DEG_SPOP_SBC_1
741:745
PTSTT
SPOP
0.9471
More...
Q92954
Proteoglycan 4
DEG_SPOP_SBC_1
810:814
PTSTT
SPOP
0.9461
More...
Q96LM5
Uncharacterized protein C4orf45
DEG_SPOP_SBC_1
9:13
PTSTT
SPOP
0.8223
More...
Q9H2X6
Homeodomain-interacting protein kinase 2
DEG_SPOP_SBC_1
795:799
PTSTT
SPOP
0.9575
More...
Q2M2H8
Probable maltase-glucoamylase 2
DEG_SPOP_SBC_1
1885:1889
PTSTT
SPOP
0.9877
More...
Q2M2H8
Probable maltase-glucoamylase 2
DEG_SPOP_SBC_1
2005:2009
PTSTT
SPOP
0.9831
More...
Q2M2H8
Probable maltase-glucoamylase 2
DEG_SPOP_SBC_1
2046:2050
PTSTT
SPOP
0.9546
More...
Q9UBL0
cAMP-regulated phosphoprotein 21
DEG_SPOP_SBC_1
647:651
PTSTT
SPOP
0.7583
More...