DegronMD - Q9UBL0(ARPP21)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E262Q	TCGA-17-Z031	LUAD	TCGA	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.1389
p.S367I	TCGA-21-1083	LUSC	TCGA	AWSST	DEG_SPOP_SBC_1	361:365	Mutation blocking phosphorylation signal	0.7222
p.S367I	DO26769	LUSC	ICGC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation blocking phosphorylation signal	0.7222
p.T652M	TCGA-29-1701	OV	TCGA	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.3056
p.T652M	TCGA-75-6203	LUAD	TCGA	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.3056
p.T652M	TCGA-AX-A2HC	UCEC	TCGA	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.3056
p.T652M	DO25887	LUAD	ICGC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.3056
p.T652M	DO29830	OV	ICGC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.3056
p.T652M	DO41572	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.3056
p.G369W	TCGA-3L-AA1B	COAD	TCGA	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2222
p.G369W	TCGA-FI-A2D4	UCEC	TCGA	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2222
p.G369W	DO50089	COAD	ICGC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2222
p.G369W	DO43170	UCEC	ICGC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2222
p.S266L	TCGA-55-8508	LUAD	TCGA	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.25
p.S266L	DO45341	LUAD	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.25
p.S278R	TCGA-85-6560	LUSC	TCGA	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation blocking phosphorylation signal	0.6667
p.S278R	DO26752	LUSC	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation blocking phosphorylation signal	0.6667
p.G645D	TCGA-A5-A0G1	UCEC	TCGA	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.2778
p.G645D	DO42472	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.2778
p.S426R	TCGA-A5-A2K5	UCEC	TCGA	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation rewiring degron network	0.25
p.S426R	DO41379	UCEC	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation rewiring degron network	0.25
p.P660L	TCGA-AA-A01Z	COAD	TCGA	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.0833
p.P660L	DO8392	COAD	ICGC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.0833
p.P660L	DO222778	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.0833
p.D260Y	TCGA-AC-A23H	BRCA	TCGA	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.0833
p.D260Y	DO2401	BRCA	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.0833
p.E271G	TCGA-AX-A05S	UCEC	TCGA	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation altering degron motif	0.7199
p.E271G	DO43218	UCEC	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation altering degron motif	0.7199
p.I431T	TCGA-B5-A3FC	UCEC	TCGA	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation altering degron motif	0.7078
p.I431T	DO41871	UCEC	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation altering degron motif	0.7078
p.P442Q	TCGA-BQ-7048	KIRP	TCGA	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation rewiring degron network	0.1667
p.P442Q	TCGA-D3-A1Q6	SKCM	TCGA	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation rewiring degron network	0.1667
p.P442Q	DO48254	ESCA	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation rewiring degron network	0.1667
p.P442Q	DO20936	KIRP	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation rewiring degron network	0.1667
p.P442Q	DO37450	SKCM	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation rewiring degron network	0.1667
p.V267A	TCGA-BS-A0UV	UCEC	TCGA	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.2778
p.V267A	DO42793	UCEC	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.2778
p.S427I	TCGA-CA-6717	COAD	TCGA	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation rewiring degron network	0.2778
p.S427I	DO8264	COAD	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation rewiring degron network	0.2778
p.S427I	DO234276	ESAD	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation rewiring degron network	0.2778
p.Q270R	TCGA-CG-5721	STAD	TCGA	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation altering degron motif	0.7329
p.Q270R	DO38192	STAD	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation altering degron motif	0.7329
p.V423A	TCGA-D3-A3ML	SKCM	TCGA	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation rewiring degron network	0.1667
p.V423A	DO47413	SKCM	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation rewiring degron network	0.1667
p.D460E	TCGA-D7-6817	STAD	TCGA	APSST	DEG_SPOP_SBC_1	458:462	Mutation altering degron motif	0.6758
p.D460E	DO38352	STAD	ICGC	APSST	DEG_SPOP_SBC_1	458:462	Mutation altering degron motif	0.6758
p.L448H	TCGA-DD-AADF	LIHC	TCGA	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.0556
p.L448H	DO52232	LIHC	ICGC	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.0556
p.P434S	TCGA-DU-6392	LGG	TCGA	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation altering degron motif	0.6752
p.P434S	TCGA-EE-A29S	SKCM	TCGA	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation altering degron motif	0.6752
p.T470P	TCGA-EB-A4XL	SKCM	TCGA	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1111
p.T470P	DO47401	SKCM	ICGC	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1111
p.G461E	TCGA-EE-A3AE	SKCM	TCGA	APSST	DEG_SPOP_SBC_1	458:462	Mutation altering degron motif	0.7199
p.G461E	DO37802	SKCM	ICGC	APSST	DEG_SPOP_SBC_1	458:462	Mutation altering degron motif	0.7199
p.D260N	TCGA-EE-A3J4	SKCM	TCGA	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.0833
p.D260N	DO48604	SKCM	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.0833
p.N467S	TCGA-EO-A22T	UCEC	TCGA	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1944
p.N467S	DO42320	UCEC	ICGC	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1944
p.Y466C	TCGA-EO-A3AV	UCEC	TCGA	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.2222
p.Y466C	DO52412	UCEC	ICGC	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.2222
p.E282G	TCGA-EO-A3B0	UCEC	TCGA	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.1111
p.E282G	DO219773	UCEC	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.1111
p.L433F	TCGA-ER-A19M	SKCM	TCGA	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation altering degron motif	0.6981
p.L433F	DO37798	SKCM	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation altering degron motif	0.6981
p.P450L	TCGA-ER-A42L	SKCM	TCGA	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1111
p.P450L	DO223910	SKCM	ICGC	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1111
p.N277H	TCGA-F5-6814	READ	TCGA	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.25
p.N277H	DO36556	READ	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.25
p.R656W	TCGA-FU-A3HZ	CESC	TCGA	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.1944
p.R656W	DO6308	CESC	ICGC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.1944
p.R656W	SIDM00438	B-Lymphoblastic Leukemia	GDSC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.1944
p.R656W	MN-60	haematopoietic and lymphoid tissue	COSMIC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.1944
p.K373T	TCGA-G3-A3CK	LIHC	TCGA	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1111
p.K373T	DO22839	LIHC	ICGC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1111
p.P643T	TCGA-G4-6309	COAD	TCGA	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.2222
p.P643T	DO7810	COAD	ICGC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.2222
p.E276K	TCGA-RP-A695	SKCM	TCGA	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.2778
p.E276K	DO51270	SKCM	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.2778
p.P450Q	TCGA-SJ-A6ZI	UCEC	TCGA	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1111
p.P450Q	DO219784	UCEC	ICGC	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1111
p.Q654K	TCGA-VQ-A8PD	STAD	TCGA	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.25
p.Q654K	DO51768	STAD	ICGC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.25
p.T651A	TCGA-VQ-A91D	STAD	TCGA	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation altering degron motif	0.7139
p.T651A	DO51783	STAD	ICGC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation altering degron motif	0.7139
p.R284T	DO219098	BLCA	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.0556
p.E283Q	DO49964	CESC	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.0833
p.L371M	DO227995	COCA	ICGC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1667
p.R366T	DO233221	GACA	ICGC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.3056
p.V423G	DO233791	GACA	ICGC	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation rewiring degron network	0.1667
p.K370T	DO233835	GACA	ICGC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1944
p.V355L	DO228921	LICA	ICGC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1667
p.V457L	DO228948	LICA	ICGC	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.3056
p.S471I	DO229019	LICA	ICGC	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.0833
p.V275L	DO229006	LICA	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.3056
p.M637I	DO229009	LICA	ICGC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.0556
p.R276G	DO25481	LUAD	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.2778
p.M459I	DO23858	LUAD	ICGC	APSST	DEG_SPOP_SBC_1	458:462	Mutation altering degron motif	0.7618
p.Q265H	DO230524	LUSC	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.2222
p.P271L	DO222595	MELA	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation altering degron motif	0.6471
p.P455S	DO222644	MELA	ICGC	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.25
p.R277Q	DO222653	MELA	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.25
p.R277Q	DO41572	UCEC	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.25
p.R277Q	SIDM01588	Endometrial Carcinoma	GDSC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.25
p.R277Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.25
p.G369R	DO222843	MELA	ICGC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2222
p.A374V	DO233294	NACA	ICGC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.D275N	DO229456	SKCA	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.3056
p.D275N	DO37432	SKCM	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.3056
p.H270Y	DO38039	SKCM	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation altering degron motif	0.6118
p.R268I	DO43041	UCEC	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.3056
p.D274Y	DO52426	UCEC	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation altering degron motif	0.7325
p.D274Y	DO41211	UCEC	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation altering degron motif	0.7325
p.K279Q	DO41133	UCEC	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation substituting flanking lysine	0.3056
p.S278N	DO42673	UCEC	ICGC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation blocking phosphorylation signal	0.6667
p.S367G	SIDM01285	Esophageal Carcinoma	GDSC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation blocking phosphorylation signal	0.7222
p.L273I	SIDM01943	Colorectal Carcinoma	GDSC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation altering degron motif	0.7174
p.A374T	SIDM00586	Hepatocellular Carcinoma	GDSC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.A374T	SIDM00338	Acute Myeloid Leukemia	GDSC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.A374T	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.A374T	SIDM00291	Melanoma	GDSC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.A374T	SIDM00002	Neuroblastoma	GDSC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.A374T	SIDM00612	Glioma	GDSC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.A374T	SIDM00245	Small Cell Lung Carcinoma	GDSC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.A374T	SIDM01454	Kidney Carcinoma	GDSC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.P660R	SIDM00960	Colorectal Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.0833
p.P660R	CL-40	large intestine	COSMIC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.0833
p.T428S	SIDM01119	Other Solid Cancers	GDSC	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation rewiring degron network	0.3056
p.T428S	NCI-H727	lung	COSMIC	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation rewiring degron network	0.3056
p.S364N	SIDM01095	Rhabdomyosarcoma	GDSC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.818
p.S364N	SJRH30	soft tissue	COSMIC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.818
p.P643S	SIDM00007	Other Solid Cancers	GDSC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.2222
p.P643S	MCC13	skin	COSMIC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.2222
p.I419L	SIDM00795	Melanoma	GDSC	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation rewiring degron network	0.0556
p.I419L	A375	skin	COSMIC	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation rewiring degron network	0.0556
p.P271Q	SIDM00193	Colorectal Carcinoma	GDSC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation altering degron motif	0.7035
p.P271Q	ACH-000991	Colon/Colorectal Cancer	CCLE	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation altering degron motif	0.7035
p.P271Q	SNU-81	large intestine	COSMIC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation altering degron motif	0.7035
p.R273K	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation altering degron motif	0.6126
p.R273K	ACH-000488	Esophageal Cancer	CCLE	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation altering degron motif	0.6126
p.R273K	TE-11	oesophagus	COSMIC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation altering degron motif	0.6126
p.A464V	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.2778
p.A464V	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.2778
p.A464V	NCI-H2135	lung	COSMIC	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.2778
p.P442S	SIDM00221	Melanoma	GDSC	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation rewiring degron network	0.1667
p.S280T	SIDM00217	Colorectal Carcinoma	GDSC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation blocking phosphorylation signal	0.6111
p.S280T	ACH-000999	Colon/Colorectal Cancer	CCLE	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation blocking phosphorylation signal	0.6111
p.S280T	SNU-1040	large intestine	COSMIC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation blocking phosphorylation signal	0.6111
p.S278G	SIDM00363	Acute Myeloid Leukemia	GDSC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation blocking phosphorylation signal	0.6667
p.S278G	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation blocking phosphorylation signal	0.6667
p.S356F	ACH-000193	Myeloma	CCLE	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1944
p.S356F	KARPAS-620	haematopoietic and lymphoid tissue	COSMIC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1944
p.I453L	ACH-000219	Skin Cancer	CCLE	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1944
p.I453L	ACH-002001	Skin Cancer	CCLE	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1944
p.I453L	ACH-002002	Skin Cancer	CCLE	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1944
p.I453L	ACH-002003	Skin Cancer	CCLE	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1944
p.I453L	A375	skin	COSMIC	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1944
p.M657K	ACH-000296	Colon/Colorectal Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.1667
p.T462S	ACH-000775	Lung Cancer	CCLE	APSST	DEG_SPOP_SBC_1	458:462	Mutation altering degron motif	0.6005
p.T462S	NCI-H727	lung	COSMIC	APSST	DEG_SPOP_SBC_1	458:462	Mutation altering degron motif	0.6005
p.P659R	ACH-000798	Colon/Colorectal Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.1111
p.P659R	CL-40	large intestine	COSMIC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.1111
p.S364R	ACH-000888	Lung Cancer	CCLE	AWSST	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.8538
p.S364R	NCI-H1793	lung	COSMIC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.8538
p.Y448C	ACH-000932	Gastric Cancer	CCLE	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.0556
p.Y448C	NCI-SNU-1	stomach	COSMIC	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.0556
p.S367A	ACH-000957	Colon/Colorectal Cancer	CCLE	AWSST	DEG_SPOP_SBC_1	361:365	Mutation blocking phosphorylation signal	0.7222
p.S367A	LS-180	large intestine	COSMIC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation blocking phosphorylation signal	0.7222
p.K354E	ACH-000970	Colon/Colorectal Cancer	CCLE	AWSST	DEG_SPOP_SBC_1	361:365	Mutation substituting flanking lysine	0.25
p.K354E	SNU-C5	large intestine	COSMIC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation substituting flanking lysine	0.25
p.P642S	ACH-001550	Skin Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.1944
p.P642S	MCC13	skin	COSMIC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.1944
p.N264S	ACH-001610	Brain Cancer	CCLE	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.1944
p.D368N	ACH-002215	Lymphoma	CCLE	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.25
p.D368N	BC-3	haematopoietic and lymphoid tissue	COSMIC	AWSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.25
p.R655W	ACH-002275	Leukemia	CCLE	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.2222
p.R655W	MN-60	haematopoietic and lymphoid tissue	COSMIC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.2222
p.G644C	SW13	adrenal gland	COSMIC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.25
p.R647K	KYSE-150	oesophagus	COSMIC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation altering degron motif	0.7237
p.A444V	NCI-H2135	lung	COSMIC	LQSTPLVS	DEG_SCF_FBW7_1	429:436	Mutation rewiring degron network	0.1111
p.A654P	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.25
p.R278G	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation blocking phosphorylation signal	0.6667
p.N280T	NCI-H2030	lung	COSMIC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation blocking phosphorylation signal	0.6111
p.G283V	CP66-MEL	skin	COSMIC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.0833
p.R456Q	CESS	haematopoietic and lymphoid tissue	COSMIC	APSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.2778
p.S284P	CTV-1	haematopoietic and lymphoid tissue	COSMIC	MHPFRD	LIG_APCC_ABBA_1	269:274	Mutation rewiring degron network	0.0556
p.G645C	SW13	adrenal gland	COSMIC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.2778
p.P640R	CL-40	large intestine	COSMIC	PTSTT	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARPP21

UniProt ID: Q9UBL0

Entrez ID: 10777

Protein name: cAMP-regulated phosphoprotein 21 (ARPP-21) (Thymocyte cAMP-regulated phosphoprotein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARPP21 in