DegronMD

Uniprot ID: Q9UBL0

Source protein: cAMP-regulated phosphoprotein 21

Source gene: ARPP21

Class: DEG_SPOP_SBC_1

Location: 361:365

E3 ligase: SPOP

DEGRON score: 0.9981

ASA_SCORE: 86.94

COIL: 0.838

CONS_SCORE: 0.5091

DSS_SCORE: 0.5305

HELIX: 0.1196

FCONS_SCORE: 1.1209

RIG_SCORE: 0.663

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S367I	TCGA-21-1083	LUSC	TCGA	AWSST	DEG_SPOP_SBC_1	0.7222
p.S367I	DO26769	LUSC	ICGC	AWSST	DEG_SPOP_SBC_1	0.7222
p.G369W	TCGA-3L-AA1B	COAD	TCGA	AWSST	DEG_SPOP_SBC_1	0.2222
p.G369W	TCGA-FI-A2D4	UCEC	TCGA	AWSST	DEG_SPOP_SBC_1	0.2222
p.G369W	DO50089	COAD	ICGC	AWSST	DEG_SPOP_SBC_1	0.2222
p.G369W	DO43170	UCEC	ICGC	AWSST	DEG_SPOP_SBC_1	0.2222
p.K373T	TCGA-G3-A3CK	LIHC	TCGA	AWSST	DEG_SPOP_SBC_1	0.1111
p.K373T	DO22839	LIHC	ICGC	AWSST	DEG_SPOP_SBC_1	0.1111
p.L371M	DO227995	COCA	ICGC	AWSST	DEG_SPOP_SBC_1	0.1667
p.R366T	DO233221	GACA	ICGC	AWSST	DEG_SPOP_SBC_1	0.3056
p.K370T	DO233835	GACA	ICGC	AWSST	DEG_SPOP_SBC_1	0.1944
p.V355L	DO228921	LICA	ICGC	AWSST	DEG_SPOP_SBC_1	0.1667
p.G369R	DO222843	MELA	ICGC	AWSST	DEG_SPOP_SBC_1	0.2222
p.A374V	DO233294	NACA	ICGC	AWSST	DEG_SPOP_SBC_1	0.0833
p.S367G	SIDM01285	Esophageal Carcinoma	GDSC	AWSST	DEG_SPOP_SBC_1	0.7222
p.A374T	SIDM00586	Hepatocellular Carcinoma	GDSC	AWSST	DEG_SPOP_SBC_1	0.0833
p.A374T	SIDM00338	Acute Myeloid Leukemia	GDSC	AWSST	DEG_SPOP_SBC_1	0.0833
p.A374T	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	AWSST	DEG_SPOP_SBC_1	0.0833
p.A374T	SIDM00291	Melanoma	GDSC	AWSST	DEG_SPOP_SBC_1	0.0833
p.A374T	SIDM00002	Neuroblastoma	GDSC	AWSST	DEG_SPOP_SBC_1	0.0833
p.A374T	SIDM00612	Glioma	GDSC	AWSST	DEG_SPOP_SBC_1	0.0833
p.A374T	SIDM00245	Small Cell Lung Carcinoma	GDSC	AWSST	DEG_SPOP_SBC_1	0.0833
p.A374T	SIDM01454	Kidney Carcinoma	GDSC	AWSST	DEG_SPOP_SBC_1	0.0833
p.S364N	SIDM01095	Rhabdomyosarcoma	GDSC	AWSST	DEG_SPOP_SBC_1	0.818
p.S364N	SJRH30	soft_tissue	COSMIC	AWSST	DEG_SPOP_SBC_1	0.818
p.S356F	ACH-000193	Myeloma	CCLE	AWSST	DEG_SPOP_SBC_1	0.1944
p.S356F	KARPAS-620	haematopoietic_and_lymphoid_tissue	COSMIC	AWSST	DEG_SPOP_SBC_1	0.1944
p.S364R	ACH-000888	Lung Cancer	CCLE	AWSST	DEG_SPOP_SBC_1	0.8538
p.S364R	NCI-H1793	lung	COSMIC	AWSST	DEG_SPOP_SBC_1	0.8538
p.S367A	ACH-000957	Colon/Colorectal Cancer	CCLE	AWSST	DEG_SPOP_SBC_1	0.7222
p.S367A	LS-180	large_intestine	COSMIC	AWSST	DEG_SPOP_SBC_1	0.7222
p.K354E	ACH-000970	Colon/Colorectal Cancer	CCLE	AWSST	DEG_SPOP_SBC_1	0.25
p.K354E	SNU-C5	large_intestine	COSMIC	AWSST	DEG_SPOP_SBC_1	0.25
p.D368N	ACH-002215	Lymphoma	CCLE	AWSST	DEG_SPOP_SBC_1	0.25
p.D368N	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	AWSST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	278:282	AWSST	SPOP	0.9013	More...
Q9UBL0	cAMP-regulated phosphoprotein 21	DEG_SPOP_SBC_1	361:365	AWSST	SPOP	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AWSST

Degron related mutations and impact score

Drug responses associated with ARPP21 mutations

All proteins holding degron of AWSST