DegronMD

Uniprot ID: O14490

Source protein: Disks large-associated protein 1

Source gene: DLGAP1

Class: DEG_SPOP_SBC_1

Location: 278:282

E3 ligase: SPOP

DEGRON score: 0.9013

ASA_SCORE: 59.28

COIL: 0.7576

CONS_SCORE: 0.3877

DSS_SCORE: 0.2829

HELIX: 0.1402

FCONS_SCORE: 1.0197

RIG_SCORE: 0.7824

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A278S	TCGA-85-7843	LUSC	TCGA	AWSST	DEG_SPOP_SBC_1	0.7588
p.A278S	DO26500	LUSC	ICGC	AWSST	DEG_SPOP_SBC_1	0.7588
p.T284I	TCGA-AJ-A8CW	UCEC	TCGA	AWSST	DEG_SPOP_SBC_1	0.2778
p.T284I	DO52400	UCEC	ICGC	AWSST	DEG_SPOP_SBC_1	0.2778
p.V285M	TCGA-BR-4292	STAD	TCGA	AWSST	DEG_SPOP_SBC_1	0.25
p.V285M	DO51493	PACA	ICGC	AWSST	DEG_SPOP_SBC_1	0.25
p.V285M	DO38495	STAD	ICGC	AWSST	DEG_SPOP_SBC_1	0.25
p.V285M	SIDM00387	Neuroblastoma	GDSC	AWSST	DEG_SPOP_SBC_1	0.25
p.V285M	ACH-000078	Neuroblastoma	CCLE	AWSST	DEG_SPOP_SBC_1	0.25
p.V285M	MHH-NB-11	autonomic_ganglia	COSMIC	AWSST	DEG_SPOP_SBC_1	0.25
p.W279C	TCGA-CR-7364	HNSC	TCGA	AWSST	DEG_SPOP_SBC_1	0.5889
p.W279C	DO15679	HNSC	ICGC	AWSST	DEG_SPOP_SBC_1	0.5889
p.A278T	TCGA-EJ-A65D	PRAD	TCGA	AWSST	DEG_SPOP_SBC_1	0.7139
p.A278T	TCGA-XK-AAIW	PRAD	TCGA	AWSST	DEG_SPOP_SBC_1	0.7139
p.A278T	DO49752	PRAD	ICGC	AWSST	DEG_SPOP_SBC_1	0.7139
p.A278T	DO51407	PRAD	ICGC	AWSST	DEG_SPOP_SBC_1	0.7139
p.R289W	TCGA-EK-A2RC	CESC	TCGA	AWSST	DEG_SPOP_SBC_1	0.1389
p.R289W	TCGA-KQ-A41Q	BLCA	TCGA	AWSST	DEG_SPOP_SBC_1	0.1389
p.R289W	DO223591	BLCA	ICGC	AWSST	DEG_SPOP_SBC_1	0.1389
p.R289W	DO49945	CESC	ICGC	AWSST	DEG_SPOP_SBC_1	0.1389
p.Q275H	DO3880	BRCA	ICGC	AWSST	DEG_SPOP_SBC_1	0.3611
p.T282M	DO222574	BTCA	ICGC	AWSST	DEG_SPOP_SBC_1	0.7423
p.A288T	DO222874	COCA	ICGC	AWSST	DEG_SPOP_SBC_1	0.1667
p.A277V	DO234271	ESAD	ICGC	AWSST	DEG_SPOP_SBC_1	0.3056
p.S286R	DO228974	LICA	ICGC	AWSST	DEG_SPOP_SBC_1	0.2222
p.Y278N	DO51193	LUAD	ICGC	AWSST	DEG_SPOP_SBC_1	0.7059
p.Q291K	DO27088	LUSC	ICGC	AWSST	DEG_SPOP_SBC_1	0.0833
p.S292Y	DO41133	UCEC	ICGC	AWSST	DEG_SPOP_SBC_1	0.0556
p.T274I	CP66-MEL	skin	COSMIC	AWSST	DEG_SPOP_SBC_1	0.2222
p.D277N	NOS-1	bone	COSMIC	AWSST	DEG_SPOP_SBC_1	0.3056
p.D285N	NOS-1	bone	COSMIC	AWSST	DEG_SPOP_SBC_1	0.25
p.A292T	8-MG-BA	central_nervous_system	COSMIC	AWSST	DEG_SPOP_SBC_1	0.0556
p.T288I	CP66-MEL	skin	COSMIC	AWSST	DEG_SPOP_SBC_1	0.1667
p.D269N	NOS-1	bone	COSMIC	AWSST	DEG_SPOP_SBC_1	0.0833
p.A286T	8-MG-BA	central_nervous_system	COSMIC	AWSST	DEG_SPOP_SBC_1	0.2222
p.D287N	NOS-1	bone	COSMIC	AWSST	DEG_SPOP_SBC_1	0.1944
p.T280I	CP66-MEL	skin	COSMIC	AWSST	DEG_SPOP_SBC_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	278:282	AWSST	SPOP	0.9013	More...
Q9UBL0	cAMP-regulated phosphoprotein 21	DEG_SPOP_SBC_1	361:365	AWSST	SPOP	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AWSST

Degron related mutations and impact score

Drug responses associated with DLGAP1 mutations

All proteins holding degron of AWSST