DegronMD - O14490(DLGAP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D733Y	TCGA-17-Z010	LUAD	TCGA	ASTST	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.3056
p.V58M	TCGA-31-1950	OV	TCGA	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.6097
p.V58M	TCGA-CK-6746	COAD	TCGA	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.6097
p.V58M	TCGA-KK-A59V	PRAD	TCGA	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.6097
p.V58M	TCGA-VQ-A91D	STAD	TCGA	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.6097
p.V58M	DO7938	COAD	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.6097
p.V58M	DO233215	GACA	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.6097
p.V58M	DO30980	OV	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.6097
p.V58M	DO51346	PRAD	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.6097
p.V58M	DO51783	STAD	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.6097
p.Y570N	TCGA-73-A9RS	LUAD	TCGA	AQSST	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.1389
p.R639S	TCGA-77-A5G6	LUSC	TCGA	VTTTT	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.0556
p.R50L	TCGA-85-6561	LUSC	TCGA	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1111
p.R50L	TCGA-BF-A1PZ	SKCM	TCGA	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1111
p.R50L	DO26518	LUSC	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1111
p.R50L	DO50279	SKCM	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1111
p.A278S	TCGA-85-7843	LUSC	TCGA	AWSST	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7588
p.A278S	DO26500	LUSC	ICGC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7588
p.P543H	TCGA-A5-A0G2	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2222
p.S735N	TCGA-A6-3809	COAD	TCGA	ASTST	DEG_SPOP_SBC_1	734:738	Mutation altering degron motif	0.5958
p.T633I	TCGA-AA-3663	COAD	TCGA	VTTTT	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.2222
p.T636M	TCGA-AA-3984	COAD	TCGA	VTTTT	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1389
p.T284I	TCGA-AJ-A8CW	UCEC	TCGA	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.2778
p.T284I	DO52400	UCEC	ICGC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.2778
p.T361M	TCGA-AX-A1C9	UCEC	TCGA	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation altering degron motif	0.7423
p.A350V	TCGA-AX-A2HD	UCEC	TCGA	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.1944
p.R548I	TCGA-B5-A0JY	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.6991
p.R548I	TCGA-BS-A0UF	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.6991
p.V285M	TCGA-BR-4292	STAD	TCGA	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.25
p.V285M	DO51493	PACA	ICGC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.25
p.V285M	DO38495	STAD	ICGC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.25
p.V285M	SIDM00387	Neuroblastoma	GDSC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.25
p.V285M	ACH-000078	Neuroblastoma	CCLE	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.25
p.V285M	MHH-NB-11	autonomic ganglia	COSMIC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.25
p.A55S	TCGA-CG-5723	STAD	TCGA	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.25
p.A55S	DO38376	STAD	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.25
p.E354D	TCGA-CM-6168	COAD	TCGA	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.3056
p.W279C	TCGA-CR-7364	HNSC	TCGA	AWSST	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.5889
p.W279C	DO15679	HNSC	ICGC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.5889
p.Q567H	TCGA-D8-A1JK	BRCA	TCGA	AQSST	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.2222
p.T624I	TCGA-EE-A29D	SKCM	TCGA	VTTTT	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.3056
p.A278T	TCGA-EJ-A65D	PRAD	TCGA	AWSST	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7139
p.A278T	TCGA-XK-AAIW	PRAD	TCGA	AWSST	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7139
p.A278T	DO49752	PRAD	ICGC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7139
p.A278T	DO51407	PRAD	ICGC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7139
p.R289W	TCGA-EK-A2RC	CESC	TCGA	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1389
p.R289W	TCGA-KQ-A41Q	BLCA	TCGA	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1389
p.R289W	DO223591	BLCA	ICGC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1389
p.R289W	DO49945	CESC	ICGC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1389
p.S366F	TCGA-EO-A22U	UCEC	TCGA	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.1944
p.S366F	COLO-792	skin	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.1944
p.R548K	TCGA-FI-A2D0	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.6126
p.R639M	TCGA-IB-7651	PAAD	TCGA	VTTTT	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.0556
p.I348M	TCGA-MT-A67F	HNSC	TCGA	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.1389
p.R71K	DO514	BLCA	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1111
p.P632R	DO224768	BRCA	ICGC	VTTTT	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.25
p.Q275H	DO3880	BRCA	ICGC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation substituting flanking lysine	0.3611
p.D371Y	DO5863	BRCA	ICGC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.0556
p.T282M	DO222574	BTCA	ICGC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7423
p.P573H	DO8018	COAD	ICGC	AQSST	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.0556
p.R540Q	DO10308	COAD	ICGC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation substituting flanking lysine	0.25
p.K538N	DO7783	COAD	ICGC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.0833
p.R70Q	DO7810	COAD	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1389
p.R70Q	DO233804	GACA	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1389
p.E52D	DO9602	COAD	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation blocking phosphorylation signal	0.6111
p.V543A	DO222864	COCA	ICGC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2222
p.A288T	DO222874	COCA	ICGC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1667
p.T59M	DO229003	COCA	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.7423
p.T59M	DO43098	UCEC	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.7423
p.A277V	DO234271	ESAD	ICGC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.3056
p.A551G	DO223060	ESCA	ICGC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.754
p.A69P	DO233937	GACA	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1667
p.G537A	DO11489	GBM	ICGC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation blocking phosphorylation signal	0.5
p.T541I	DO48516	KIRP	ICGC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation blocking phosphorylation signal	0.6111
p.T541I	CW-2	large intestine	COSMIC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation blocking phosphorylation signal	0.6111
p.S286R	DO228974	LICA	ICGC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.2222
p.A620D	DO229019	LICA	ICGC	VTTTT	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1944
p.S68R	DO229037	LICA	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1944
p.P625Q	DO229045	LICA	ICGC	VTTTT	DEG_SPOP_SBC_1	625:629	Mutation altering degron motif	0.7035
p.T48I	DO52171	LIHC	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.0556
p.G537E	DO45163	LIRI	ICGC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation blocking phosphorylation signal	0.5
p.G537E	DO37406	SKCM	ICGC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation blocking phosphorylation signal	0.5
p.P567R	DO25967	LUAD	ICGC	AQSST	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.2222
p.E369D	DO25947	LUAD	ICGC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.1111
p.Y278N	DO51193	LUAD	ICGC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7059
p.H570Y	DO26469	LUSC	ICGC	AQSST	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.1389
p.R347S	DO50097	LUSC	ICGC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.1111
p.I360F	DO219211	LUSC	ICGC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation altering degron motif	0.7415
p.Q291K	DO27088	LUSC	ICGC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.0833
p.D56N	DO228858	MALY	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2778
p.P61S	DO222875	MELA	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.6752
p.P61S	DO229459	SKCA	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.6752
p.R356Q	DO222908	MELA	ICGC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation altering degron motif	0.7329
p.R347M	DO46657	PAAD	ICGC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.1111
p.R558K	DO48899	PBCA	ICGC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.R558K	DO48899	PBCA	ICGC	AQSST	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.3056
p.C561G	DO47436	SKCM	ICGC	AQSST	DEG_SPOP_SBC_1	559:563	Mutation altering degron motif	0.76
p.A542T	DO52402	UCEC	ICGC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1944
p.K553I	DO41536	UCEC	ICGC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2778
p.K553I	DO41536	UCEC	ICGC	AQSST	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.1667
p.Q547L	DO52424	UCEC	ICGC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.7765
p.A48V	DO42608	UCEC	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.0556
p.S64F	DO43755	UCEC	ICGC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.3056
p.G544D	DO41199	UCEC	ICGC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.25
p.S292Y	DO41133	UCEC	ICGC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.0556
p.V739A	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASTST	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.3056
p.V739A	ACH-000914	Lymphoma	CCLE	ASTST	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.3056
p.V739A	HT	haematopoietic and lymphoid tissue	COSMIC	ASTST	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.3056
p.R50Q	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1111
p.R50Q	ACH-002313	Lymphoma	CCLE	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1111
p.R50Q	TK	haematopoietic and lymphoid tissue	COSMIC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1111
p.V625I	SIDM00590	Oral Cavity Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	625:629	Mutation altering degron motif	0.7076
p.V625I	ACH-000472	Head and Neck Cancer	CCLE	VTTTT	DEG_SPOP_SBC_1	625:629	Mutation altering degron motif	0.7076
p.M351I	SIDM00533	Pancreatic Carcinoma	GDSC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.2222
p.M351I	ACH-000118	Pancreatic Cancer	CCLE	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.2222
p.M351I	HuP-T3	pancreas	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.2222
p.R732H	SIDM00251	Gastric Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.2778
p.R732H	SIDM00500	Colorectal Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.2778
p.R732H	ACH-000949	Gastric Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.2778
p.R732H	ACH-000959	Colon/Colorectal Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.2778
p.R732H	TGBC11TKB	stomach	COSMIC	ASTST	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.2778
p.A371V	SIDM01051	Ovarian Carcinoma	GDSC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.0556
p.A371V	ACH-000936	Ovarian Cancer	CCLE	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.0556
p.A371V	EFO-27	ovary	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.0556
p.Y748H	SIDM01608	Endometrial Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.0556
p.Y748H	ACH-000990	Endometrial/Uterine Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.0556
p.S362N	SIDM01387	Small Cell Lung Carcinoma	GDSC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.3056
p.S362N	ACH-000921	Lung Cancer	CCLE	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.3056
p.S737C	ACH-000961	Endometrial/Uterine Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	734:738	Mutation altering degron motif	0.7541
p.N562S	NCI-H1048	lung	COSMIC	AQSST	DEG_SPOP_SBC_1	559:563	Mutation altering degron motif	0.7069
p.A69V	EFO-27	ovary	COSMIC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1667
p.R70W	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1389
p.T619P	Daudi	haematopoietic and lymphoid tissue	COSMIC	VTTTT	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1667
p.T619P	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VTTTT	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1667
p.T274I	CP66-MEL	skin	COSMIC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.2222
p.N540S	NCI-H1048	lung	COSMIC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation substituting flanking lysine	0.25
p.M57I	HuP-T3	pancreas	COSMIC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.3056
p.D277N	NOS-1	bone	COSMIC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.3056
p.K347R	KOSC-2	upper aerodigestive tract	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.1111
p.D573E	DU-145	prostate	COSMIC	AQSST	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.0556
p.D285N	NOS-1	bone	COSMIC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.25
p.K349R	KOSC-2	upper aerodigestive tract	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation substituting flanking lysine	0.2778
p.A292T	8-MG-BA	central nervous system	COSMIC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.0556
p.T288I	CP66-MEL	skin	COSMIC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1667
p.D269N	NOS-1	bone	COSMIC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.0833
p.A357S	A427	lung	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation altering degron motif	0.7588
p.A367S	A427	lung	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.1667
p.D565E	DU-145	prostate	COSMIC	AQSST	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.2778
p.G570R	NCI-H630	large intestine	COSMIC	AQSST	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.1389
p.M49I	HuP-T3	pancreas	COSMIC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.0833
p.T623A	Daudi	haematopoietic and lymphoid tissue	COSMIC	VTTTT	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.2778
p.T539I	CW-2	large intestine	COSMIC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation substituting flanking lysine	0.2222
p.N546S	NCI-H1048	lung	COSMIC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.3056
p.A349S	A427	lung	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation substituting flanking lysine	0.2778
p.A365S	A427	lung	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.2222
p.M59I	HuP-T3	pancreas	COSMIC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.7618
p.N554S	NCI-H1048	lung	COSMIC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.25
p.N554S	NCI-H1048	lung	COSMIC	AQSST	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.1944
p.G562R	NCI-H630	large intestine	COSMIC	AQSST	DEG_SPOP_SBC_1	559:563	Mutation altering degron motif	0.7568
p.T555I	CW-2	large intestine	COSMIC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2222
p.T555I	CW-2	large intestine	COSMIC	AQSST	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.2222
p.G556R	NCI-H630	large intestine	COSMIC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1944
p.G556R	NCI-H630	large intestine	COSMIC	AQSST	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.25
p.T549I	CW-2	large intestine	COSMIC	PRTTT	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.7078
p.M63I	HuP-T3	pancreas	COSMIC	VGPFSD	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.7618
p.N564S	NCI-H1048	lung	COSMIC	AQSST	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.3056
p.D559E	DU-145	prostate	COSMIC	AQSST	DEG_SPOP_SBC_1	559:563	Mutation altering degron motif	0.6758
p.A286T	8-MG-BA	central nervous system	COSMIC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.2222
p.D287N	NOS-1	bone	COSMIC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1944
p.T621A	DU-4475	breast	COSMIC	VTTTT	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.2222
p.N572S	NCI-H1048	lung	COSMIC	AQSST	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.0833
p.K357R	KOSC-2	upper aerodigestive tract	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation altering degron motif	0.7237
p.K363R	KOSC-2	upper aerodigestive tract	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation rewiring degron network	0.2778
p.T280I	CP66-MEL	skin	COSMIC	AWSST	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7078
p.S360F	COLO-792	skin	COSMIC	DSGDSDT	DEG_SCF_TRCP1_1	355:361	Mutation altering degron motif	0.7982

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DLGAP1

UniProt ID: O14490

Entrez ID: 9229

Protein name: Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DLGAP1 in