DegronMD

Uniprot ID: O14490

Source protein: Disks large-associated protein 1

Source gene: DLGAP1

Class: LIG_APCC_ABBA_1

Location: 58:63

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9968

ASA_SCORE: 59.7

COIL: 0.922

CONS_SCORE: 0.3458

DSS_SCORE: 0.4299

HELIX: 0.0233

FCONS_SCORE: 0.7948

RIG_SCORE: 0.705

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V58M	TCGA-31-1950	OV	TCGA	VGPFSD	LIG_APCC_ABBA_1	0.6097
p.V58M	TCGA-CK-6746	COAD	TCGA	VGPFSD	LIG_APCC_ABBA_1	0.6097
p.V58M	TCGA-KK-A59V	PRAD	TCGA	VGPFSD	LIG_APCC_ABBA_1	0.6097
p.V58M	TCGA-VQ-A91D	STAD	TCGA	VGPFSD	LIG_APCC_ABBA_1	0.6097
p.V58M	DO7938	COAD	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.6097
p.V58M	DO233215	GACA	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.6097
p.V58M	DO30980	OV	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.6097
p.V58M	DO51346	PRAD	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.6097
p.V58M	DO51783	STAD	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.6097
p.R50L	TCGA-85-6561	LUSC	TCGA	VGPFSD	LIG_APCC_ABBA_1	0.1111
p.R50L	TCGA-BF-A1PZ	SKCM	TCGA	VGPFSD	LIG_APCC_ABBA_1	0.1111
p.R50L	DO26518	LUSC	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.1111
p.R50L	DO50279	SKCM	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.1111
p.A55S	TCGA-CG-5723	STAD	TCGA	VGPFSD	LIG_APCC_ABBA_1	0.25
p.A55S	DO38376	STAD	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.25
p.R71K	DO514	BLCA	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.1111
p.R70Q	DO7810	COAD	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.1389
p.R70Q	DO233804	GACA	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.1389
p.E52D	DO9602	COAD	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.6111
p.T59M	DO229003	COCA	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.7423
p.T59M	DO43098	UCEC	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.7423
p.A69P	DO233937	GACA	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.1667
p.S68R	DO229037	LICA	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.1944
p.T48I	DO52171	LIHC	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.0556
p.D56N	DO228858	MALY	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.2778
p.P61S	DO222875	MELA	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.6752
p.P61S	DO229459	SKCA	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.6752
p.A48V	DO42608	UCEC	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.0556
p.S64F	DO43755	UCEC	ICGC	VGPFSD	LIG_APCC_ABBA_1	0.3056
p.R50Q	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	VGPFSD	LIG_APCC_ABBA_1	0.1111
p.R50Q	ACH-002313	Lymphoma	CCLE	VGPFSD	LIG_APCC_ABBA_1	0.1111
p.R50Q	TK	haematopoietic_and_lymphoid_tissue	COSMIC	VGPFSD	LIG_APCC_ABBA_1	0.1111
p.A69V	EFO-27	ovary	COSMIC	VGPFSD	LIG_APCC_ABBA_1	0.1667
p.R70W	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	VGPFSD	LIG_APCC_ABBA_1	0.1389
p.M57I	HuP-T3	pancreas	COSMIC	VGPFSD	LIG_APCC_ABBA_1	0.3056
p.M49I	HuP-T3	pancreas	COSMIC	VGPFSD	LIG_APCC_ABBA_1	0.0833
p.M59I	HuP-T3	pancreas	COSMIC	VGPFSD	LIG_APCC_ABBA_1	0.7618
p.M63I	HuP-T3	pancreas	COSMIC	VGPFSD	LIG_APCC_ABBA_1	0.7618

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGPFSD

Degron related mutations and impact score

Drug responses associated with DLGAP1 mutations

All proteins holding degron of VGPFSD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14490	Disks large-associated protein 1	LIG_APCC_ABBA_1	58:63	VGPFSD	APC,CDC20,FZR1	0.9968	More...