DegronMD

Uniprot ID: O14490

Source protein: Disks large-associated protein 1

Source gene: DLGAP1

Class: DEG_SPOP_SBC_1

Location: 625:629

E3 ligase: SPOP

DEGRON score: 0.9294

ASA_SCORE: 86.94

COIL: 0.7734

CONS_SCORE: 0.3526

DSS_SCORE: 0.452

HELIX: 0.0322

FCONS_SCORE: 0.9447

RIG_SCORE: 0.7866

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R639S	TCGA-77-A5G6	LUSC	TCGA	VTTTT	DEG_SPOP_SBC_1	0.0556
p.T633I	TCGA-AA-3663	COAD	TCGA	VTTTT	DEG_SPOP_SBC_1	0.2222
p.T636M	TCGA-AA-3984	COAD	TCGA	VTTTT	DEG_SPOP_SBC_1	0.1389
p.T624I	TCGA-EE-A29D	SKCM	TCGA	VTTTT	DEG_SPOP_SBC_1	0.3056
p.R639M	TCGA-IB-7651	PAAD	TCGA	VTTTT	DEG_SPOP_SBC_1	0.0556
p.P632R	DO224768	BRCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.25
p.A620D	DO229019	LICA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1944
p.P625Q	DO229045	LICA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7035
p.V625I	SIDM00590	Oral Cavity Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.7076
p.V625I	ACH-000472	Head and Neck Cancer	CCLE	VTTTT	DEG_SPOP_SBC_1	0.7076
p.T619P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VTTTT	DEG_SPOP_SBC_1	0.1667
p.T619P	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	VTTTT	DEG_SPOP_SBC_1	0.1667
p.T623A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VTTTT	DEG_SPOP_SBC_1	0.2778
p.T621A	DU-4475	breast	COSMIC	VTTTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	625:629	VTTTT	SPOP	0.9294	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	388:392	VTTTT	SPOP	0.8483	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	763:767	VTTTT	SPOP	0.7448	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1516:1520	VTTTT	SPOP	0.7066	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1893:1897	VTTTT	SPOP	0.6112	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1751:1755	VTTTT	SPOP	0.9422	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	3959:3963	VTTTT	SPOP	0.9114	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6984:6988	VTTTT	SPOP	0.9363	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7102:7106	VTTTT	SPOP	0.7934	More...
Q8TCZ2	CD99 antigen-like protein 2	DEG_SPOP_SBC_1	98:102	VTTTT	SPOP	0.9976	More...
Q9P265	Disco-interacting protein 2 homolog B	DEG_SPOP_SBC_1	222:226	VTTTT	SPOP	0.9648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons