DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SPOP_SBC_1

Location: 1516:1520

E3 ligase: SPOP

DEGRON score: 0.7066

ASA_SCORE: 91.7

COIL: 0.8832

CONS_SCORE: 0.4534

DSS_SCORE: 0.5117

HELIX: 0.0126

FCONS_SCORE: 1

RIG_SCORE: 0.7855

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1523S	SIDM01237	Hepatocellular Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.25
p.T1519N	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.7055
p.S1526G	SIDM00365	Small Cell Lung Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.1667
p.P1511H	SIDM00672	Hepatocellular Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.1944
p.P1511H	SIDM00118	Colorectal Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.1944
p.P1511H	SIDM01409	Bladder Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.1944
p.E1506G	SIDM01588	Endometrial Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	625:629	VTTTT	SPOP	0.9294	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	388:392	VTTTT	SPOP	0.8483	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	763:767	VTTTT	SPOP	0.7448	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1516:1520	VTTTT	SPOP	0.7066	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1893:1897	VTTTT	SPOP	0.6112	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1751:1755	VTTTT	SPOP	0.9422	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	3959:3963	VTTTT	SPOP	0.9114	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6984:6988	VTTTT	SPOP	0.9363	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7102:7106	VTTTT	SPOP	0.7934	More...
Q8TCZ2	CD99 antigen-like protein 2	DEG_SPOP_SBC_1	98:102	VTTTT	SPOP	0.9976	More...
Q9P265	Disco-interacting protein 2 homolog B	DEG_SPOP_SBC_1	222:226	VTTTT	SPOP	0.9648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons