DegronMD

Uniprot ID: Q8TCZ2

Source protein: CD99 antigen-like protein 2

Source gene: CD99L2

Class: DEG_SPOP_SBC_1

Location: 98:102

E3 ligase: SPOP

DEGRON score: 0.9976

ASA_SCORE: 86.88

COIL: 0.9122

CONS_SCORE: 0.4422

DSS_SCORE: 0.616

HELIX: 0.0266

FCONS_SCORE: 1.1822

RIG_SCORE: 0.7529

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H97N	TCGA-56-8625	LUSC	TCGA	VTTTT	DEG_SPOP_SBC_1	0.3056
p.H97N	DO229038	LICA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.3056
p.H97N	DO45515	LUSC	ICGC	VTTTT	DEG_SPOP_SBC_1	0.3056
p.P111A	TCGA-91-6829	LUAD	TCGA	VTTTT	DEG_SPOP_SBC_1	0.0833
p.P111A	DO23564	LUAD	ICGC	VTTTT	DEG_SPOP_SBC_1	0.0833
p.T101M	TCGA-AD-6895	COAD	TCGA	VTTTT	DEG_SPOP_SBC_1	0.7423
p.T101M	DO8938	COAD	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7423
p.T107N	TCGA-C4-A0EZ	BLCA	TCGA	VTTTT	DEG_SPOP_SBC_1	0.1944
p.T107N	DO476	BLCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1944
p.K103N	TCGA-CK-5913	COAD	TCGA	VTTTT	DEG_SPOP_SBC_1	0.3056
p.K103N	DO8826	COAD	ICGC	VTTTT	DEG_SPOP_SBC_1	0.3056
p.T99I	TCGA-EB-A24D	SKCM	TCGA	VTTTT	DEG_SPOP_SBC_1	0.5966
p.T99I	DO37440	SKCM	ICGC	VTTTT	DEG_SPOP_SBC_1	0.5966
p.S112F	DO217962	BRCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.0556
p.G90V	DO225215	BRCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1111
p.G90V	DO227836	BRCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1111
p.Y98H	DO233784	GACA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7229
p.S99C	DO233852	GACA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7541
p.G99V	DO22237	LGG	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7532
p.T100N	DO229032	LICA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7055
p.G105V	DO23717	LUAD	ICGC	VTTTT	DEG_SPOP_SBC_1	0.25
p.R97P	DO23586	LUAD	ICGC	VTTTT	DEG_SPOP_SBC_1	0.3056
p.D103N	DO37412	SKCM	ICGC	VTTTT	DEG_SPOP_SBC_1	0.3056
p.V109M	DO51761	STAD	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1389
p.D103G	DO222356	STAD	ICGC	VTTTT	DEG_SPOP_SBC_1	0.3056
p.K91N	DO39720	THCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1389
p.T112A	SIDM01247	Burkitt's Lymphoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.0556
p.G94R	SIDM00391	Plasma Cell Myeloma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.G94R	SK-MM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.G90R	ACH-000363	Myeloma	CCLE	VTTTT	DEG_SPOP_SBC_1	0.1111
p.G90R	SK-MM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VTTTT	DEG_SPOP_SBC_1	0.1111
p.I104K	ACH-000394	Lung Cancer	CCLE	VTTTT	DEG_SPOP_SBC_1	0.2778
p.I104K	NCI-H2081	lung	COSMIC	VTTTT	DEG_SPOP_SBC_1	0.2778
p.I90T	ACH-000831	Endometrial/Uterine Cancer	CCLE	VTTTT	DEG_SPOP_SBC_1	0.1111
p.I90T	ACH-002201	Cervical Cancer	CCLE	VTTTT	DEG_SPOP_SBC_1	0.1111
p.I90T	TC-YIK	cervix	COSMIC	VTTTT	DEG_SPOP_SBC_1	0.1111
p.G106W	ACH-000833	Sarcoma	CCLE	VTTTT	DEG_SPOP_SBC_1	0.2222
p.G106W	SJRH30	soft_tissue	COSMIC	VTTTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	625:629	VTTTT	SPOP	0.9294	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	388:392	VTTTT	SPOP	0.8483	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	763:767	VTTTT	SPOP	0.7448	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1516:1520	VTTTT	SPOP	0.7066	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1893:1897	VTTTT	SPOP	0.6112	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1751:1755	VTTTT	SPOP	0.9422	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	3959:3963	VTTTT	SPOP	0.9114	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6984:6988	VTTTT	SPOP	0.9363	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7102:7106	VTTTT	SPOP	0.7934	More...
Q8TCZ2	CD99 antigen-like protein 2	DEG_SPOP_SBC_1	98:102	VTTTT	SPOP	0.9976	More...
Q9P265	Disco-interacting protein 2 homolog B	DEG_SPOP_SBC_1	222:226	VTTTT	SPOP	0.9648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTTTT

Degron related mutations and impact score

Drug responses associated with CD99L2 mutations

All proteins holding degron of VTTTT