DegronMD

Uniprot ID: Q9P265

Source protein: Disco-interacting protein 2 homolog B

Source gene: DIP2B

Class: DEG_SPOP_SBC_1

Location: 222:226

E3 ligase: SPOP

DEGRON score: 0.9648

ASA_SCORE: 68.18

COIL: 0.8598

CONS_SCORE: 0.0795

DSS_SCORE: 0.5746

HELIX: 0.0784

FCONS_SCORE: 0.938

RIG_SCORE: 0.6859

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S232Y	TCGA-AA-A010	COAD	TCGA	VTTTT	DEG_SPOP_SBC_1	0.1667
p.R212Q	TCGA-AG-A002	READ	TCGA	VTTTT	DEG_SPOP_SBC_1	0.0556
p.R212Q	TCGA-D3-A8GM	SKCM	TCGA	VTTTT	DEG_SPOP_SBC_1	0.0556
p.R212Q	DO50288	SKCM	ICGC	VTTTT	DEG_SPOP_SBC_1	0.0556
p.E214D	TCGA-AP-A1E0	UCEC	TCGA	VTTTT	DEG_SPOP_SBC_1	0.1111
p.E214D	DO43154	UCEC	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1111
p.R236C	TCGA-D1-A1NY	UCEC	TCGA	VTTTT	DEG_SPOP_SBC_1	0.0556
p.R236C	DO42512	UCEC	ICGC	VTTTT	DEG_SPOP_SBC_1	0.0556
p.S217C	TCGA-DF-A2KR	UCEC	TCGA	VTTTT	DEG_SPOP_SBC_1	0.1944
p.S217C	DO223284	UCEC	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1944
p.T226I	DO225346	BRCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7078
p.S228F	DO222536	MELA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	625:629	VTTTT	SPOP	0.9294	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	388:392	VTTTT	SPOP	0.8483	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	763:767	VTTTT	SPOP	0.7448	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1516:1520	VTTTT	SPOP	0.7066	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1893:1897	VTTTT	SPOP	0.6112	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1751:1755	VTTTT	SPOP	0.9422	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	3959:3963	VTTTT	SPOP	0.9114	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6984:6988	VTTTT	SPOP	0.9363	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7102:7106	VTTTT	SPOP	0.7934	More...
Q8TCZ2	CD99 antigen-like protein 2	DEG_SPOP_SBC_1	98:102	VTTTT	SPOP	0.9976	More...
Q9P265	Disco-interacting protein 2 homolog B	DEG_SPOP_SBC_1	222:226	VTTTT	SPOP	0.9648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons