DegronMD - Q02505(MUC3A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S271R	TCGA-05-4427	LUAD	TCGA	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0833
p.S271R	DO23666	LUAD	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0833
p.T472N	TCGA-05-5425	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2778
p.T472N	DO26270	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2778
p.V408A	TCGA-06-5416	GBM	TCGA	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.25
p.V408A	DO10880	GBM	ICGC	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.25
p.V439I	TCGA-06-6388	GBM	TCGA	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1667
p.V439I	TCGA-27-1834	GBM	TCGA	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1667
p.V439I	DO233154	GACA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1667
p.V439I	DO13300	GBM	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1667
p.V439I	DO14109	GBM	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1667
p.L305I	TCGA-13-0890	OV	TCGA	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1944
p.L305I	DO28273	OV	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1944
p.P409L	TCGA-14-3476	GBM	TCGA	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.2778
p.P409L	DO11417	GBM	ICGC	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.2778
p.T379I	TCGA-22-5472	LUSC	TCGA	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.T379I	TCGA-22-5472	LUSC	TCGA	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0833
p.T379I	DO27421	LUSC	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.T379I	DO27421	LUSC	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0833
p.P242R	TCGA-24-1474	OV	TCGA	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0556
p.P242R	DO31919	OV	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0556
p.A703D	TCGA-33-4583	LUSC	TCGA	LPTPNAS	DEG_SCF_FBW7_1	696:702	Mutation rewiring degron network	0.3056
p.A703D	DO27112	LUSC	ICGC	LPTPNAS	DEG_SCF_FBW7_1	696:702	Mutation rewiring degron network	0.3056
p.G753C	TCGA-34-8455	LUSC	TCGA	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation substituting flanking lysine	0.1667
p.G753C	DO50095	LUSC	ICGC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation substituting flanking lysine	0.1667
p.D678Y	TCGA-43-A56V	LUSC	TCGA	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.25
p.D678Y	DO45535	LUSC	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.25
p.G514V	TCGA-44-6778	LUAD	TCGA	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.2222
p.G514V	DO25603	LUAD	ICGC	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.2222
p.V431A	TCGA-44-7670	LUAD	TCGA	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation altering degron motif	0.6936
p.V431A	DO23555	LUAD	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation altering degron motif	0.6936
p.T660I	TCGA-4Z-AA86	BLCA	TCGA	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.1111
p.T660I	DO218989	BLCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.1111
p.T660I	DO220900	MELA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.1111
p.T660N	TCGA-51-4081	LUSC	TCGA	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.1111
p.T660N	DO26544	LUSC	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.1111
p.L525I	TCGA-55-7995	LUAD	TCGA	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.3056
p.L525I	DO228813	LICA	ICGC	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.3056
p.L525I	DO45323	LUAD	ICGC	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.3056
p.S422I	TCGA-56-A62T	LUSC	TCGA	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1389
p.S422I	TCGA-56-A62T	LUSC	TCGA	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1389
p.S422I	DO219144	LUSC	ICGC	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1389
p.S422I	DO219144	LUSC	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1389
p.L286V	TCGA-63-5131	LUSC	TCGA	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.L286V	DO26898	LUSC	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.G515V	TCGA-64-5781	LUAD	TCGA	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.25
p.G515V	DO23740	LUAD	ICGC	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.25
p.K685N	TCGA-80-5608	LUAD	TCGA	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.0556
p.K685N	DO23693	LUAD	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.0556
p.C511Y	TCGA-90-7964	LUSC	TCGA	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.1389
p.C511Y	DO27046	LUSC	ICGC	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.1389
p.S440C	TCGA-98-8021	LUSC	TCGA	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1389
p.S440C	DO27468	LUSC	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1389
p.E180D	TCGA-A5-A2K5	UCEC	TCGA	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1944
p.E180D	TCGA-A5-A2K5	UCEC	TCGA	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.0556
p.E180D	DO41379	UCEC	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1944
p.E180D	DO41379	UCEC	ICGC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.0556
p.S416I	TCGA-AJ-A5DW	UCEC	TCGA	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.3056
p.S416I	DO50075	UCEC	ICGC	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.3056
p.Q521P	TCGA-AP-A1DV	UCEC	TCGA	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation altering degron motif	0.7035
p.Q521P	DO43186	UCEC	ICGC	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation altering degron motif	0.7035
p.A709T	TCGA-AP-A1DV	UCEC	TCGA	LPTPNAS	DEG_SCF_FBW7_1	696:702	Mutation rewiring degron network	0.1389
p.A709T	DO43186	UCEC	ICGC	LPTPNAS	DEG_SCF_FBW7_1	696:702	Mutation rewiring degron network	0.1389
p.T254N	TCGA-AX-A05Z	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.7055
p.T254N	DO40884	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.7055
p.S385Y	TCGA-B5-A1MR	UCEC	TCGA	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.25
p.S385Y	DO41758	UCEC	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.25
p.G406E	TCGA-B5-A3FC	UCEC	TCGA	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1944
p.G406E	DO41871	UCEC	ICGC	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1944
p.P443S	TCGA-BF-A3DL	SKCM	TCGA	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.0556
p.P443S	DO51238	SKCM	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.0556
p.P247L	TCGA-BF-AAOX	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1944
p.P247L	DO223907	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1944
p.S249F	TCGA-BF-AAP0	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.25
p.S249F	TCGA-BF-AAP0	SKCM	TCGA	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0833
p.S249F	DO219462	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.25
p.S249F	DO219462	SKCM	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0833
p.M387I	TCGA-BF-AAP0	SKCM	TCGA	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.3056
p.M387I	DO219462	SKCM	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.3056
p.S466P	TCGA-BR-8360	STAD	TCGA	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1111
p.S466P	DO47745	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1111
p.V269M	TCGA-C4-A0EZ	BLCA	TCGA	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1389
p.V269M	DO476	BLCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1389
p.Q193K	TCGA-C5-A7UI	CESC	TCGA	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.6944
p.Q193K	DO49892	CESC	ICGC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.6944
p.T405S	TCGA-CD-8529	STAD	TCGA	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1667
p.T405S	DO47753	STAD	ICGC	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1667
p.D512H	TCGA-CV-7414	HNSC	TCGA	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.1667
p.D512H	DO15631	HNSC	ICGC	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.1667
p.W765L	TCGA-D3-A1Q3	SKCM	TCGA	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation altering degron motif	0.7015
p.W765L	DO47509	SKCM	ICGC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation altering degron motif	0.7015
p.S257F	TCGA-D3-A2JF	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.3056
p.S257F	TCGA-D3-A2JF	SKCM	TCGA	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.3056
p.S257F	DO38153	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.3056
p.S257F	DO38153	SKCM	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.3056
p.S257F	SIDM00140	Melanoma	GDSC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.3056
p.S257F	SIDM00140	Melanoma	GDSC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.3056
p.S257F	ACH-000968	Skin Cancer	CCLE	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.3056
p.S257F	ACH-000968	Skin Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.3056
p.S257F	COLO-792	skin	COSMIC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.3056
p.S257F	COLO-792	skin	COSMIC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.3056
p.G527E	TCGA-D3-A8GK	SKCM	TCGA	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.25
p.G527E	TCGA-HU-A4G6	STAD	TCGA	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.25
p.G527E	DO50286	SKCM	ICGC	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.25
p.G527E	DO47747	STAD	ICGC	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.25
p.A523V	TCGA-DF-A2KR	UCEC	TCGA	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation altering degron motif	0.6936
p.A523V	DO223284	UCEC	ICGC	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation altering degron motif	0.6936
p.T294N	TCGA-DF-A2KU	UCEC	TCGA	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.7055
p.T294N	DO223286	UCEC	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.7055
p.V800A	TCGA-DX-A3UF	SARC	TCGA	VTSTS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.2222
p.V800A	DO219982	SARC	ICGC	VTSTS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.2222
p.L525F	TCGA-EE-A2GR	SKCM	TCGA	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.3056
p.L525F	DO37996	SKCM	ICGC	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.3056
p.P310L	TCGA-EE-A2MD	SKCM	TCGA	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0556
p.P310L	DO222434	MELA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0556
p.P310L	DO37851	SKCM	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0556
p.P284L	TCGA-EE-A2MP	SKCM	TCGA	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0833
p.P284L	DO37818	SKCM	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0833
p.S265F	TCGA-EE-A2MU	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0833
p.S265F	TCGA-EE-A2MU	SKCM	TCGA	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.25
p.S265F	DO37436	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0833
p.S265F	DO37436	SKCM	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.25
p.S265F	ACH-000960	Leukemia	CCLE	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0833
p.S265F	ACH-000960	Leukemia	CCLE	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.25
p.A669V	TCGA-EJ-7782	PRAD	TCGA	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.6936
p.A669V	DO36256	PRAD	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.6936
p.S244P	TCGA-EO-A22R	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1111
p.S244P	DO42713	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1111
p.Y381F	TCGA-EO-A22X	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.Y381F	TCGA-EO-A22X	UCEC	TCGA	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1389
p.Y381F	DO43907	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.Y381F	DO43907	UCEC	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1389
p.N411H	TCGA-EO-A22X	UCEC	TCGA	VSTST	DEG_SPOP_SBC_1	411:415	Mutation altering degron motif	0.7423
p.N411H	DO43907	UCEC	ICGC	VSTST	DEG_SPOP_SBC_1	411:415	Mutation altering degron motif	0.7423
p.C676Y	TCGA-EO-A3AU	UCEC	TCGA	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.3056
p.C676Y	DO43827	UCEC	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.3056
p.T248N	TCGA-EO-A3AY	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.2222
p.T248N	TCGA-EO-A3AY	UCEC	TCGA	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.T248N	DO43202	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.2222
p.T248N	DO43202	UCEC	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.Y557C	TCGA-F1-6875	STAD	TCGA	PASTS	DEG_SPOP_SBC_1	556:560	Mutation altering degron motif	0.7087
p.Y557C	DO38731	STAD	ICGC	PASTS	DEG_SPOP_SBC_1	556:560	Mutation altering degron motif	0.7087
p.Y557C	ACH-000594	Lung Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	556:560	Mutation altering degron motif	0.7087
p.A304T	TCGA-FI-A2D5	UCEC	TCGA	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2222
p.A304T	DO41331	UCEC	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2222
p.V413I	TCGA-FR-A8YC	SKCM	TCGA	VSTST	DEG_SPOP_SBC_1	411:415	Mutation altering degron motif	0.7076
p.V413I	DO220885	MELA	ICGC	VSTST	DEG_SPOP_SBC_1	411:415	Mutation altering degron motif	0.7076
p.V413I	DO50301	SKCM	ICGC	VSTST	DEG_SPOP_SBC_1	411:415	Mutation altering degron motif	0.7076
p.S255F	TCGA-FS-A1ZA	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.7982
p.S255F	DO37551	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.7982
p.E423K	TCGA-G2-A2EF	BLCA	TCGA	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1111
p.E423K	TCGA-G2-A2EF	BLCA	TCGA	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1667
p.E423K	DO726	BLCA	ICGC	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1111
p.E423K	DO726	BLCA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1667
p.S473L	TCGA-G2-A3IE	BLCA	TCGA	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.3056
p.S473L	DO767	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.3056
p.E364K	TCGA-GF-A6C9	SKCM	TCGA	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2222
p.E364K	TCGA-W3-AA1V	SKCM	TCGA	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2222
p.E364K	DO51276	SKCM	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2222
p.E364K	DO51254	SKCM	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2222
p.E364K	ACH-000740	Head and Neck Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2222
p.P254S	TCGA-GN-A265	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.6752
p.P254S	DO37491	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.6752
p.S588L	TCGA-L5-A8NI	ESCA	TCGA	PPSTT	DEG_SPOP_SBC_1	586:590	Mutation altering degron motif	0.7667
p.S588L	DO27825	MALY	ICGC	PPSTT	DEG_SPOP_SBC_1	586:590	Mutation altering degron motif	0.7667
p.G527V	TCGA-MN-A4N5	LUAD	TCGA	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.25
p.G527V	DO45332	LUAD	ICGC	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.25
p.G527V	ACH-002295	Head and Neck Cancer	CCLE	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.25
p.I269N	TCGA-NJ-A4YI	LUAD	TCGA	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1389
p.I269N	DO218942	LUAD	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1389
p.P710L	TCGA-NJ-A4YQ	LUAD	TCGA	LPTPNAS	DEG_SCF_FBW7_1	696:702	Mutation rewiring degron network	0.1111
p.P710L	DO218944	LUAD	ICGC	LPTPNAS	DEG_SCF_FBW7_1	696:702	Mutation rewiring degron network	0.1111
p.T195N	TCGA-P5-A5EV	LGG	TCGA	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1667
p.T195N	TCGA-P5-A5EV	LGG	TCGA	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.3056
p.T195N	DO50160	LGG	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1667
p.T195N	DO50160	LGG	ICGC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.3056
p.S200L	TCGA-PE-A5DE	BRCA	TCGA	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1667
p.S200L	DO219643	BRCA	ICGC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1667
p.T297S	TCGA-RP-A695	SKCM	TCGA	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.7116
p.T297S	DO51270	SKCM	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.7116
p.P526S	TCGA-W3-AA1O	SKCM	TCGA	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.2778
p.P526S	DO51274	SKCM	ICGC	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.2778
p.M382I	TCGA-W3-AA1V	SKCM	TCGA	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0556
p.M382I	TCGA-W3-AA1V	SKCM	TCGA	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1667
p.M382I	DO51276	SKCM	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0556
p.M382I	DO51276	SKCM	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1667
p.S679F	TCGA-WE-A8K5	SKCM	TCGA	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.2222
p.S679F	DO51282	SKCM	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.2222
p.P264S	TCGA-WE-AAA3	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1111
p.P264S	TCGA-WE-AAA3	SKCM	TCGA	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.2778
p.P264S	DO229465	SKCA	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1111
p.P264S	DO229465	SKCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.2778
p.P264S	DO51295	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1111
p.P264S	DO51295	SKCM	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.2778
p.P185L	TCGA-YD-A89C	SKCM	TCGA	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.7582
p.P185L	DO219501	SKCM	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.7582
p.S466F	TCGA-YD-A9TA	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1111
p.S466F	DO219503	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1111
p.S295C	DO224768	BRCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.643
p.T487I	DO1110	BRCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.0833
p.S300P	DO227709	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.6752
p.T183M	DO224645	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2778
p.T183M	DO224645	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1389
p.T475I	DO224661	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.7078
p.T475I	DO224744	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.7078
p.T475I	DO222800	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.7078
p.T475I	DO229010	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.7078
p.T475I	DO229005	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.7078
p.S396T	DO224674	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396T	DO224639	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396T	DO222748	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396T	DO229010	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396T	DO229013	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396T	DO229016	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396T	DO229003	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396T	DO229005	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396T	DO229006	LICA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396T	DO229148	THCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396T	DO229272	THCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396T	DO229084	THCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S175P	DO224674	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.S175P	DO229010	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.S175P	DO229013	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.S175P	DO229016	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.S175P	DO229003	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.S175P	DO229005	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.S396L	DO224674	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396L	DO222748	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396L	DO229010	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396L	DO229013	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396L	DO229016	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396L	DO229003	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396L	DO229005	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396L	DO229006	LICA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396L	DO229148	THCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396L	DO229272	THCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396L	DO229085	THCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.S396L	DO229084	THCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.M388T	DO224674	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation altering degron motif	0.7423
p.M388T	DO229010	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation altering degron motif	0.7423
p.M388T	DO229013	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation altering degron motif	0.7423
p.M388T	DO229016	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation altering degron motif	0.7423
p.M388T	DO229003	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation altering degron motif	0.7423
p.M388T	DO229005	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation altering degron motif	0.7423
p.M388T	DO50991	LAML	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation altering degron motif	0.7423
p.M388T	DO51000	LAML	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation altering degron motif	0.7423
p.M388T	DO229024	LICA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation altering degron motif	0.7423
p.T303A	DO224616	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.T303A	DO224739	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.T303A	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.T303A	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.T303A	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.T303A	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.A755T	DO224639	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1111
p.A755T	DO229010	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1111
p.A755T	DO229013	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1111
p.A755T	DO229016	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1111
p.A755T	DO229003	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1111
p.A755T	DO229005	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1111
p.A755T	DO229250	THCA	ICGC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1111
p.S262T	DO224639	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6005
p.S262T	DO224812	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6005
p.S262T	DO229010	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6005
p.S262T	DO229013	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6005
p.S262T	DO229016	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6005
p.S262T	DO229003	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6005
p.S262T	DO229005	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6005
p.S262T	DO229259	THCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6005
p.S262T	DO229257	THCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6005
p.S262T	DO229213	THCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6005
p.G712D	DO224708	COCA	ICGC	LPTPNAS	DEG_SCF_FBW7_1	696:702	Mutation rewiring degron network	0.0556
p.A673V	DO224721	COCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.6936
p.A673V	DO222760	COCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.6936
p.A673V	DO222853	COCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.6936
p.A673V	DO229010	COCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.6936
p.A673V	DO229013	COCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.6936
p.A673V	DO229016	COCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.6936
p.A673V	DO229003	COCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.6936
p.A673V	DO229005	COCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.6936
p.A673V	DO230659	LAML	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.6936
p.A673V	DO50989	LAML	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.6936
p.A673V	DO231140	LAML	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.6936
p.A673V	DO218847	SKCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.6936
p.A673V	DO229221	THCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.6936
p.P476S	DO224808	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.6752
p.P476S	DO229010	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.6752
p.P476S	DO229013	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.6752
p.P476S	DO229016	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.6752
p.P476S	DO229003	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.6752
p.P476S	DO229005	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.6752
p.P476S	DO229006	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.6752
p.P476S	DO233476	PRAD	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.6752
p.T470A	DO224808	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.T470A	DO229010	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.T470A	DO229013	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.T470A	DO229016	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.T470A	DO229003	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.T470A	DO229005	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.T470A	DO229192	THCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.T470A	DO229257	THCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.T470A	DO229232	THCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.T470A	DO229242	THCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.A304G	DO224801	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2222
p.G307R	DO222485	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.G307R	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.G307R	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.G307R	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.G307R	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.G307R	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.G307D	DO222485	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.G307D	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.G307D	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.G307D	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.G307D	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.G307D	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.R290S	DO222553	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.R290S	DO222840	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.R290S	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.R290S	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.R290S	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.R290S	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.P288L	DO222553	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1944
p.P288L	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1944
p.P288L	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1944
p.P288L	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1944
p.P288L	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1944
p.E702A	DO222560	COCA	ICGC	LPTPNAS	DEG_SCF_FBW7_1	696:702	Mutation altering degron motif	0.7701
p.E702A	DO222813	COCA	ICGC	LPTPNAS	DEG_SCF_FBW7_1	696:702	Mutation altering degron motif	0.7701
p.E702A	DO229010	COCA	ICGC	LPTPNAS	DEG_SCF_FBW7_1	696:702	Mutation altering degron motif	0.7701
p.E702A	DO229013	COCA	ICGC	LPTPNAS	DEG_SCF_FBW7_1	696:702	Mutation altering degron motif	0.7701
p.E702A	DO229016	COCA	ICGC	LPTPNAS	DEG_SCF_FBW7_1	696:702	Mutation altering degron motif	0.7701
p.E702A	DO229003	COCA	ICGC	LPTPNAS	DEG_SCF_FBW7_1	696:702	Mutation altering degron motif	0.7701
p.E702A	DO229005	COCA	ICGC	LPTPNAS	DEG_SCF_FBW7_1	696:702	Mutation altering degron motif	0.7701
p.T661M	DO222709	COCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.1389
p.T661M	DO233873	GACA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.1389
p.T661M	DO231220	LAML	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.1389
p.I374M	DO222718	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.I374M	DO229010	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.I374M	DO229013	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.I374M	DO229016	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.I374M	DO229003	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.I374M	DO229005	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.I374M	DO51000	LAML	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.V182F	DO222822	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.25
p.V182F	DO222822	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1111
p.V182F	DO229010	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.25
p.V182F	DO229010	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1111
p.V182F	DO229013	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.25
p.V182F	DO229013	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1111
p.V182F	DO229016	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.25
p.V182F	DO229016	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1111
p.V182F	DO229003	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.25
p.V182F	DO229003	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1111
p.V182F	DO229005	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.25
p.V182F	DO229005	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1111
p.V182F	DO229211	THCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.25
p.V182F	DO229211	THCA	ICGC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1111
p.T289I	DO222840	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2222
p.T289I	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2222
p.T291N	DO222840	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2778
p.T291N	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2778
p.T187I	DO229010	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.7078
p.T187I	DO229013	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.7078
p.T187I	DO229016	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.7078
p.T187I	DO229003	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.7078
p.T187I	DO229005	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.7078
p.L299P	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.6471
p.L299P	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.6471
p.L299P	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.6471
p.L299P	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.6471
p.L299P	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.6471
p.L299P	DO46897	RECA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.6471
p.S488T	DO229010	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.0556
p.S488T	DO229013	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.0556
p.S488T	DO229016	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.0556
p.S488T	DO229003	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.0556
p.S488T	DO229005	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.0556
p.S488T	DO51025	LAML	ICGC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.0556
p.L434P	DO229010	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.L434P	DO229013	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.L434P	DO229016	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.L434P	DO229003	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.L434P	DO229005	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.L434P	DO50980	LAML	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.L434P	DO51040	LAML	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.L434P	DO51026	LAML	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.L434P	DO229257	THCA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.T370S	DO229010	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.6005
p.T370S	DO229013	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.6005
p.T370S	DO229016	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.6005
p.T370S	DO229003	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.6005
p.T370S	DO229005	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.6005
p.T370S	DO229024	LICA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.6005
p.T370S	DO229211	THCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.6005
p.T370S	DO229232	THCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.6005
p.T370S	DO229092	THCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.6005
p.A290S	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.A290S	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.A290S	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.A290S	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.A290S	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.A290S	DO229024	LICA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.I304T	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2222
p.I304T	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2222
p.I304T	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2222
p.I304T	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2222
p.N310T	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0556
p.N310T	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0556
p.N310T	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0556
p.V298A	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.5825
p.V298A	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.5825
p.T198I	DO229010	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation blocking phosphorylation signal	0.5278
p.T198I	DO229010	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation blocking phosphorylation signal	0.6667
p.T198I	DO229013	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation blocking phosphorylation signal	0.5278
p.T198I	DO229013	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation blocking phosphorylation signal	0.6667
p.T198I	DO229016	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation blocking phosphorylation signal	0.5278
p.T198I	DO229016	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation blocking phosphorylation signal	0.6667
p.T198I	DO229003	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation blocking phosphorylation signal	0.5278
p.T198I	DO229003	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation blocking phosphorylation signal	0.6667
p.T198I	DO229005	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation blocking phosphorylation signal	0.5278
p.T198I	DO229005	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation blocking phosphorylation signal	0.6667
p.S296P	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.6752
p.S296P	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.6752
p.S296P	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.6752
p.S296P	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.6752
p.S296P	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.6752
p.S296P	DO229024	LICA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.6752
p.Y381H	DO229010	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.Y381H	DO229010	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1389
p.Y381H	DO229013	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.Y381H	DO229013	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1389
p.Y381H	DO229016	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.Y381H	DO229016	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1389
p.Y381H	DO229003	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.Y381H	DO229003	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1389
p.Y381H	DO229005	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.Y381H	DO229005	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1389
p.Y381H	DO50991	LAML	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.Y381H	DO50991	LAML	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1389
p.Y381H	DO51025	LAML	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.Y381H	DO51025	LAML	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1389
p.Y381H	DO51011	LAML	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.Y381H	DO51011	LAML	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1389
p.Y381H	DO229024	LICA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.Y381H	DO229024	LICA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1389
p.L434I	DO229010	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.L434I	DO229013	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.L434I	DO229016	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.L434I	DO229003	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.L434I	DO229005	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.L434I	DO50980	LAML	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.L434I	DO51040	LAML	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.L434I	DO229253	THCA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.T379A	DO229010	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.T379A	DO229010	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0833
p.T379A	DO229013	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.T379A	DO229013	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0833
p.T379A	DO229016	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.T379A	DO229016	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0833
p.T379A	DO229003	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.T379A	DO229003	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0833
p.T379A	DO229005	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.T379A	DO229005	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0833
p.T379A	DO50991	LAML	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.T379A	DO50991	LAML	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0833
p.T379A	DO51025	LAML	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.T379A	DO51025	LAML	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0833
p.T379A	DO51011	LAML	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.T379A	DO51011	LAML	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0833
p.T379A	DO51012	LAML	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.T379A	DO51012	LAML	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0833
p.T379A	DO229024	LICA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.T379A	DO229024	LICA	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0833
p.V177M	DO229010	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.V177M	DO229013	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.V177M	DO229016	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.V177M	DO229003	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.V177M	DO229005	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.V177M	DO229006	LICA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.V177M	DO229211	THCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.S300N	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.7069
p.S300N	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.7069
p.S429N	DO229010	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation altering degron motif	0.7069
p.S429N	DO229013	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation altering degron motif	0.7069
p.S429N	DO229016	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation altering degron motif	0.7069
p.S429N	DO229003	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation altering degron motif	0.7069
p.S429N	DO229005	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation altering degron motif	0.7069
p.S429N	DO229140	THCA	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation altering degron motif	0.7069
p.S257A	DO229010	COCA	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.3056
p.S257A	DO229010	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.3056
p.S257A	DO229013	COCA	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.3056
p.S257A	DO229013	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.3056
p.S257A	DO229016	COCA	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.3056
p.S257A	DO229016	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.3056
p.S257A	DO229003	COCA	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.3056
p.S257A	DO229003	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.3056
p.S257A	DO229005	COCA	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.3056
p.S257A	DO229005	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.3056
p.T175K	DO229010	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.T175K	DO229013	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.T175K	DO229016	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.T175K	DO229003	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.T175K	DO229005	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.T175K	DO229211	THCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.I308T	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1111
p.I308T	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1111
p.I308T	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1111
p.I308T	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1111
p.I308T	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1111
p.P258S	DO229010	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6752
p.P258S	DO229013	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6752
p.P258S	DO229005	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6752
p.P258S	DO230659	LAML	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6752
p.P258S	DO51022	LAML	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6752
p.P258S	DO231140	LAML	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6752
p.P258S	DO229047	LICA	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6752
p.T303I	DO229010	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.T303I	DO229013	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.T303I	DO229016	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.T303I	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.T303I	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.T291S	DO229003	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2778
p.N310D	DO229005	COCA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0556
p.R804L	DO50446	ESAD	ICGC	VTSTS	DEG_SPOP_SBC_1	804:808	Mutation altering degron motif	0.8428
p.S285C	DO234202	ESAD	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1111
p.G406R	DO233086	GACA	ICGC	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1944
p.Q597H	DO233235	GACA	ICGC	PPSTT	DEG_SPOP_SBC_1	586:590	Mutation rewiring degron network	0.1389
p.A669T	DO233261	GACA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.7139
p.C561F	DO229018	LICA	ICGC	PASTS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.3056
p.R290M	DO229036	LICA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.V366F	DO229035	LICA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.P369L	DO50970	LICA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.6471
p.I252V	DO23274	LINC	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.7076
p.Y557H	DO230538	LUSC	ICGC	PASTS	DEG_SPOP_SBC_1	556:560	Mutation altering degron motif	0.7229
p.W517L	DO224566	LUSC	ICGC	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.3056
p.W517L	DO231007	LUSC	ICGC	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.3056
p.S251C	DO224599	LUSC	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.3056
p.S251C	DO224599	LUSC	ICGC	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1389
p.S189F	DO52680	MALY	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.7982
p.P589R	DO220851	MELA	ICGC	PPSTT	DEG_SPOP_SBC_1	586:590	Mutation altering degron motif	0.7512
p.P199S	DO220889	MELA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.P199S	DO220889	MELA	ICGC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1944
p.D512A	DO220890	MELA	ICGC	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.1667
p.P284S	DO222868	MELA	ICGC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0833
p.P360S	DO222843	MELA	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1111
p.P360S	ACH-000865	Esophageal Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1111
p.I442N	DO46372	OV	ICGC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.0833
p.T660S	DO46354	OV	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.1111
p.S670N	DO51528	PACA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.5958
p.P589L	DO49439	PACA	ICGC	PPSTT	DEG_SPOP_SBC_1	586:590	Mutation altering degron motif	0.7582
p.F256S	DO232761	PBCA	ICGC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.7982
p.N674T	DO232224	PBCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.7055
p.M382V	DO51965	PRAD	ICGC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0556
p.M382V	DO51965	PRAD	ICGC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1667
p.S559F	DO229453	SKCA	ICGC	PASTS	DEG_SPOP_SBC_1	556:560	Mutation altering degron motif	0.7982
p.P183S	DO229453	SKCA	ICGC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2778
p.P183S	DO229453	SKCA	ICGC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1389
p.A802V	DO229199	THCA	ICGC	VTSTS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.2778
p.T2544I	SIDM01943	Colorectal Carcinoma	GDSC	VGTTS	DEG_SPOP_SBC_1	2541:2545	Mutation altering degron motif	0.7078
p.V2551L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VGTTS	DEG_SPOP_SBC_1	2541:2545	Mutation rewiring degron network	0.1667
p.V2551L	KCL-22	haematopoietic and lymphoid tissue	COSMIC	VGTTS	DEG_SPOP_SBC_1	2541:2545	Mutation rewiring degron network	0.1667
p.T760A	SIDM00484	Thyroid Gland Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.25
p.T760A	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.25
p.T760A	SIDM00660	Colorectal Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.25
p.T760A	SIDM01664	Prostate Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.25
p.T760A	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.25
p.T760A	SIDM01451	Pancreatic Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.25
p.E2870D	SIDM00216	Colorectal Carcinoma	GDSC	VFTST	DEG_SPOP_SBC_1	2860:2864	Mutation rewiring degron network	0.1667
p.E2870D	SNU-175	large intestine	COSMIC	VFTST	DEG_SPOP_SBC_1	2860:2864	Mutation rewiring degron network	0.1667
p.P758H	SIDM00672	Hepatocellular Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1944
p.P758H	SIDM00393	Gastric Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1944
p.P758H	SIDM00118	Colorectal Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1944
p.P1888L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PTSSS	DEG_SPOP_SBC_1	1874:1878	Mutation rewiring degron network	0.0556
p.P1888L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VTTTT	DEG_SPOP_SBC_1	1893:1897	Mutation rewiring degron network	0.1944
p.S2709Y	SIDM00428	Acute Myeloid Leukemia	GDSC	ITPVFS	DEG_SCF_FBW7_1	2699:2704	Mutation rewiring degron network	0.1944
p.S2709Y	SIDM00428	Acute Myeloid Leukemia	GDSC	VFSTT	DEG_SPOP_SBC_1	2702:2706	Mutation rewiring degron network	0.25
p.S2709Y	SIDM00672	Hepatocellular Carcinoma	GDSC	ITPVFS	DEG_SCF_FBW7_1	2699:2704	Mutation rewiring degron network	0.1944
p.S2709Y	SIDM00672	Hepatocellular Carcinoma	GDSC	VFSTT	DEG_SPOP_SBC_1	2702:2706	Mutation rewiring degron network	0.25
p.S2709Y	SIDM00393	Gastric Carcinoma	GDSC	ITPVFS	DEG_SCF_FBW7_1	2699:2704	Mutation rewiring degron network	0.1944
p.S2709Y	SIDM00393	Gastric Carcinoma	GDSC	VFSTT	DEG_SPOP_SBC_1	2702:2706	Mutation rewiring degron network	0.25
p.S2709Y	SIDM00118	Colorectal Carcinoma	GDSC	ITPVFS	DEG_SCF_FBW7_1	2699:2704	Mutation rewiring degron network	0.1944
p.S2709Y	SIDM00118	Colorectal Carcinoma	GDSC	VFSTT	DEG_SPOP_SBC_1	2702:2706	Mutation rewiring degron network	0.25
p.S771L	SIDM00962	Chronic Myelogenous Leukemia	GDSC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.2222
p.S1499T	SIDM00962	Chronic Myelogenous Leukemia	GDSC	PPTSS	DEG_SPOP_SBC_1	1496:1500	Mutation altering degron motif	0.6005
p.S806P	SIDM01261	Breast Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	804:808	Mutation altering degron motif	0.6752
p.S806P	SIDM00314	Breast Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	804:808	Mutation altering degron motif	0.6752
p.M1133I	SIDM00967	Ovarian Carcinoma	GDSC	MTPTTT	DEG_SCF_FBW7_1	1133:1138	Mutation altering degron motif	0.6507
p.T1134S	SIDM00967	Ovarian Carcinoma	GDSC	MTPTTT	DEG_SCF_FBW7_1	1133:1138	Mutation altering degron motif	0.7116
p.T1523S	SIDM01237	Hepatocellular Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	1516:1520	Mutation rewiring degron network	0.25
p.I2573L	SIDM01483	Melanoma	GDSC	IPETPTQT	DEG_SCF_FBW7_1	2573:2580	Mutation altering degron motif	0.6063
p.I2573L	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	IPETPTQT	DEG_SCF_FBW7_1	2573:2580	Mutation altering degron motif	0.6063
p.I2573L	COLO-741	large intestine	COSMIC	IPETPTQT	DEG_SCF_FBW7_1	2573:2580	Mutation altering degron motif	0.6063
p.I2573L	NCI-H1869	lung	COSMIC	IPETPTQT	DEG_SCF_FBW7_1	2573:2580	Mutation altering degron motif	0.6063
p.T2399A	SIDM01126	Small Cell Lung Carcinoma	GDSC	ITPGLT	DEG_SCF_FBW7_1	2405:2410	Mutation rewiring degron network	0.1667
p.T2399A	SIDM00846	Cervical Carcinoma	GDSC	ITPGLT	DEG_SCF_FBW7_1	2405:2410	Mutation rewiring degron network	0.1667
p.T2399A	SIDM00633	Breast Carcinoma	GDSC	ITPGLT	DEG_SCF_FBW7_1	2405:2410	Mutation rewiring degron network	0.1667
p.T2399A	SIDM01099	Neuroblastoma	GDSC	ITPGLT	DEG_SCF_FBW7_1	2405:2410	Mutation rewiring degron network	0.1667
p.S2538L	SIDM01175	Other Sarcomas	GDSC	VGTTS	DEG_SPOP_SBC_1	2541:2545	Mutation rewiring degron network	0.25
p.S2538L	SW684	soft tissue	COSMIC	VGTTS	DEG_SPOP_SBC_1	2541:2545	Mutation rewiring degron network	0.25
p.T1059I	SIDM00693	Bladder Carcinoma	GDSC	LSSTPVPS	DEG_SCF_FBW7_1	1044:1051	Mutation rewiring degron network	0.1111
p.S1811G	SIDM00846	Cervical Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	1797:1801	Mutation rewiring degron network	0.0556
p.S1811G	SIDM00633	Breast Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	1797:1801	Mutation rewiring degron network	0.0556
p.S1811G	SIDM00493	Other Solid Cancers	GDSC	VSSST	DEG_SPOP_SBC_1	1797:1801	Mutation rewiring degron network	0.0556
p.S2545C	SIDM00923	Cervical Carcinoma	GDSC	VGTTS	DEG_SPOP_SBC_1	2541:2545	Mutation altering degron motif	0.8652
p.S2545C	Ca-Ski	cervix	COSMIC	VGTTS	DEG_SPOP_SBC_1	2541:2545	Mutation altering degron motif	0.8652
p.P1761S	SIDM01164	Glioma	GDSC	AVSST	DEG_SPOP_SBC_1	1756:1760	Mutation rewiring degron network	0.3056
p.P1761S	SIDM01041	Esophageal Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	1756:1760	Mutation rewiring degron network	0.3056
p.P1761S	SIDM00813	Non-Cancerous	GDSC	AVSST	DEG_SPOP_SBC_1	1756:1760	Mutation rewiring degron network	0.3056
p.P1761S	SIDM00518	Mesothelioma	GDSC	AVSST	DEG_SPOP_SBC_1	1756:1760	Mutation rewiring degron network	0.3056
p.P1761S	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	1756:1760	Mutation rewiring degron network	0.3056
p.P1761S	SIDM00335	Endometrial Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	1756:1760	Mutation rewiring degron network	0.3056
p.T381K	SIDM00555	Glioblastoma	GDSC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.T381K	SIDM00555	Glioblastoma	GDSC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1389
p.T381K	SIDM00530	Esophageal Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.T381K	SIDM00530	Esophageal Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1389
p.T381K	SIDM00301	Pancreatic Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.T381K	SIDM00301	Pancreatic Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1389
p.T381K	SIDM01695	Acute Myeloid Leukemia	GDSC	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.T381K	SIDM01695	Acute Myeloid Leukemia	GDSC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1389
p.S2863R	SIDM00555	Glioblastoma	GDSC	VFTST	DEG_SPOP_SBC_1	2860:2864	Mutation altering degron motif	0.7427
p.S2863R	KS-1	central nervous system	COSMIC	VFTST	DEG_SPOP_SBC_1	2860:2864	Mutation altering degron motif	0.7427
p.S2712F	SIDM00447	B-Lymphoblastic Leukemia	GDSC	ITPVFS	DEG_SCF_FBW7_1	2699:2704	Mutation rewiring degron network	0.1111
p.S2712F	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VFSTT	DEG_SPOP_SBC_1	2702:2706	Mutation rewiring degron network	0.1667
p.S2712F	REH	haematopoietic and lymphoid tissue	COSMIC	ITPVFS	DEG_SCF_FBW7_1	2699:2704	Mutation rewiring degron network	0.1111
p.S2712F	REH	haematopoietic and lymphoid tissue	COSMIC	VFSTT	DEG_SPOP_SBC_1	2702:2706	Mutation rewiring degron network	0.1667
p.D1219N	SIDM00193	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	1226:1230	Mutation rewiring degron network	0.1389
p.T1895M	SIDM00193	Colorectal Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	1893:1897	Mutation altering degron motif	0.7423
p.A1380T	SIDM00660	Colorectal Carcinoma	GDSC	AMTST	DEG_SPOP_SBC_1	1380:1384	Mutation altering degron motif	0.7139
p.P2510S	SIDM00660	Colorectal Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	2497:2501	Mutation rewiring degron network	0.0833
p.P2510S	SIDM00516	Melanoma	GDSC	VGTST	DEG_SPOP_SBC_1	2497:2501	Mutation rewiring degron network	0.0833
p.P2510S	SIDM00808	Burkitt's Lymphoma	GDSC	VGTST	DEG_SPOP_SBC_1	2497:2501	Mutation rewiring degron network	0.0833
p.P2510S	SIDM01173	Rhabdomyosarcoma	GDSC	VGTST	DEG_SPOP_SBC_1	2497:2501	Mutation rewiring degron network	0.0833
p.P2510S	SIDM01254	Burkitt's Lymphoma	GDSC	VGTST	DEG_SPOP_SBC_1	2497:2501	Mutation rewiring degron network	0.0833
p.S2534I	SIDM01178	Other Solid Cancers	GDSC	VGTTS	DEG_SPOP_SBC_1	2541:2545	Mutation rewiring degron network	0.1389
p.P1564T	SIDM00293	Small Cell Lung Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	1557:1561	Mutation rewiring degron network	0.25
p.M428V	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.A591T	SIDM00530	Esophageal Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	586:590	Mutation rewiring degron network	0.3056
p.T1015I	SIDM00095	Glioblastoma	GDSC	ITPTNT	DEG_SCF_FBW7_1	1014:1019	Mutation altering degron motif	0.7078
p.T204A	SIDM01039	Other Solid Cancers	GDSC	PSTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.0556
p.S294C	SIDM00287	B-Lymphoblastic Leukemia	GDSC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.643
p.S294C	BALL-1	haematopoietic and lymphoid tissue	COSMIC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.643
p.I2707V	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	ITPVFS	DEG_SCF_FBW7_1	2699:2704	Mutation rewiring degron network	0.25
p.I2707V	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	VFSTT	DEG_SPOP_SBC_1	2702:2706	Mutation rewiring degron network	0.3056
p.I2707V	HCE-4	oesophagus	COSMIC	ITPVFS	DEG_SCF_FBW7_1	2699:2704	Mutation rewiring degron network	0.25
p.I2707V	HCE-4	oesophagus	COSMIC	VFSTT	DEG_SPOP_SBC_1	2702:2706	Mutation rewiring degron network	0.3056
p.T179N	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1667
p.T179N	ACH-000929	Lung Cancer	CCLE	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1667
p.T179N	NCI-H2110	lung	COSMIC	AMTSS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1667
p.S395F	SIDM00971	Breast Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.25
p.S395F	ZR-75-30	breast	COSMIC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.25
p.P1144H	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	ITTTPNTT	DEG_SCF_FBW7_1	1140:1147	Mutation altering degron motif	0.7694
p.P1144H	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PNTTS	DEG_SPOP_SBC_1	1144:1148	Mutation altering degron motif	0.7694
p.T1519N	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	1516:1520	Mutation altering degron motif	0.7055
p.V2541E	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VGTTS	DEG_SPOP_SBC_1	2541:2545	Mutation altering degron motif	0.7693
p.V2541E	H513	pleura	COSMIC	VGTTS	DEG_SPOP_SBC_1	2541:2545	Mutation altering degron motif	0.7693
p.P2711S	SIDM00801	Melanoma	GDSC	ITPVFS	DEG_SCF_FBW7_1	2699:2704	Mutation rewiring degron network	0.1389
p.P2711S	SIDM00801	Melanoma	GDSC	VFSTT	DEG_SPOP_SBC_1	2702:2706	Mutation rewiring degron network	0.1944
p.P2711S	A101D	skin	COSMIC	ITPVFS	DEG_SCF_FBW7_1	2699:2704	Mutation rewiring degron network	0.1389
p.P2711S	A101D	skin	COSMIC	VFSTT	DEG_SPOP_SBC_1	2702:2706	Mutation rewiring degron network	0.1944
p.T1486A	SIDM00948	Burkitt's Lymphoma	GDSC	PPTSS	DEG_SPOP_SBC_1	1496:1500	Mutation rewiring degron network	0.0556
p.T2207S	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	2215:2219	Mutation rewiring degron network	0.1111
p.T2207S	SIDM00097	Breast Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	2215:2219	Mutation rewiring degron network	0.1111
p.T2207S	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSSST	DEG_SPOP_SBC_1	2215:2219	Mutation rewiring degron network	0.1111
p.S1526G	SIDM00365	Small Cell Lung Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	1516:1520	Mutation rewiring degron network	0.1667
p.S2849F	SIDM00003	Melanoma	GDSC	ASSST	DEG_SPOP_SBC_1	2846:2850	Mutation altering degron motif	0.7982
p.S2849F	M14	skin	COSMIC	ASSST	DEG_SPOP_SBC_1	2846:2850	Mutation altering degron motif	0.7982
p.T2544S	SIDM00875	Breast Carcinoma	GDSC	VGTTS	DEG_SPOP_SBC_1	2541:2545	Mutation altering degron motif	0.6005
p.T2544S	SIDM00844	Burkitt's Lymphoma	GDSC	VGTTS	DEG_SPOP_SBC_1	2541:2545	Mutation altering degron motif	0.6005
p.P1511H	SIDM00672	Hepatocellular Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	1516:1520	Mutation rewiring degron network	0.1944
p.P1511H	SIDM00118	Colorectal Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	1516:1520	Mutation rewiring degron network	0.1944
p.P1511H	SIDM01409	Bladder Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	1516:1520	Mutation rewiring degron network	0.1944
p.S1759C	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	1756:1760	Mutation altering degron motif	0.7541
p.P2844L	SIDM00483	Esophageal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	2846:2850	Mutation rewiring degron network	0.2778
p.P2844L	SK-GT-4	oesophagus	COSMIC	ASSST	DEG_SPOP_SBC_1	2846:2850	Mutation rewiring degron network	0.2778
p.P400S	SIDM00892	Breast Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1111
p.P400S	BT-483	breast	COSMIC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1111
p.S488F	SIDM00140	Melanoma	GDSC	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.0556
p.S2565F	SIDM00140	Melanoma	GDSC	IPETPTQT	DEG_SCF_FBW7_1	2573:2580	Mutation rewiring degron network	0.1111
p.S2565F	COLO-792	skin	COSMIC	IPETPTQT	DEG_SCF_FBW7_1	2573:2580	Mutation rewiring degron network	0.1111
p.T243A	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0833
p.T243A	NCI-H1770	lung	COSMIC	AVTST	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0833
p.P2856H	SIDM00927	Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	2846:2850	Mutation rewiring degron network	0.1667
p.P2856H	SIDM00927	Small Cell Lung Carcinoma	GDSC	VFTST	DEG_SPOP_SBC_1	2860:2864	Mutation rewiring degron network	0.2222
p.P2856H	NCI-H510A	lung	COSMIC	ASSST	DEG_SPOP_SBC_1	2846:2850	Mutation rewiring degron network	0.1667
p.P2856H	NCI-H510A	lung	COSMIC	VFTST	DEG_SPOP_SBC_1	2860:2864	Mutation rewiring degron network	0.2222
p.T2871I	SIDM01133	Other Solid Cancers	GDSC	VFTST	DEG_SPOP_SBC_1	2860:2864	Mutation rewiring degron network	0.1389
p.L1149F	SIDM00324	Neuroblastoma	GDSC	LSTPSFT	DEG_SCF_FBW7_1	1149:1155	Mutation altering degron motif	0.6981
p.V1502F	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	1496:1500	Mutation rewiring degron network	0.2778
p.L387S	SIDM00217	Colorectal Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.3056
p.L387S	SNU-1040	large intestine	COSMIC	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.3056
p.T2505A	SIDM00534	Colorectal Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	2497:2501	Mutation rewiring degron network	0.2222
p.I2570N	SIDM01001	Breast Carcinoma	GDSC	IPETPTQT	DEG_SCF_FBW7_1	2573:2580	Mutation rewiring degron network	0.25
p.T1143A	SIDM00118	Colorectal Carcinoma	GDSC	ITTTPNTT	DEG_SCF_FBW7_1	1140:1147	Mutation altering degron motif	0.7139
p.K756E	SIDM00591	Oral Cavity Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation substituting flanking lysine	0.25
p.S1124F	SIDM01059	Melanoma	GDSC	MTPTTT	DEG_SCF_FBW7_1	1133:1138	Mutation rewiring degron network	0.0833
p.S1124F	SIDM01059	Melanoma	GDSC	PPTSS	DEG_SPOP_SBC_1	1119:1123	Mutation rewiring degron network	0.3056
p.T1551S	SIDM01582	Gastric Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	1557:1561	Mutation rewiring degron network	0.1667
p.K753Q	SIDM01336	Glioblastoma	GDSC	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation substituting flanking lysine	0.1667
p.H1902R	SIDM01591	Breast Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	1893:1897	Mutation rewiring degron network	0.1944
p.S2695P	SIDM00011	Melanoma	GDSC	ITPVFS	DEG_SCF_FBW7_1	2699:2704	Mutation rewiring degron network	0.2222
p.S2695P	SIDM00011	Melanoma	GDSC	VFSTT	DEG_SPOP_SBC_1	2702:2706	Mutation rewiring degron network	0.1389
p.S2455Y	SIDM01387	Small Cell Lung Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	2452:2456	Mutation altering degron motif	0.712
p.E1506G	SIDM01588	Endometrial Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	1496:1500	Mutation rewiring degron network	0.1667
p.E1506G	SIDM01588	Endometrial Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	1516:1520	Mutation rewiring degron network	0.0556
p.P2701L	SIDM01451	Pancreatic Carcinoma	GDSC	ITPVFS	DEG_SCF_FBW7_1	2699:2704	Mutation altering degron motif	0.7582
p.T2487R	SIDM01434	Hepatocellular Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	2497:2501	Mutation rewiring degron network	0.0556
p.Q671E	ACH-000069	Lymphoma	CCLE	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation altering degron motif	0.6744
p.P468T	ACH-000290	Lung Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1667
p.Q521H	ACH-000401	Skin Cancer	CCLE	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation altering degron motif	0.7582
p.R801L	ACH-000607	Rhabdoid	CCLE	VTSTS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.25
p.S416R	ACH-000631	Brain Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.3056
p.C705Y	ACH-000723	Head and Neck Cancer	CCLE	LPTPNAS	DEG_SCF_FBW7_1	696:702	Mutation rewiring degron network	0.25
p.A478S	ACH-000775	Lung Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.7588
p.Q519H	ACH-000775	Lung Cancer	CCLE	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation altering degron motif	0.7582
p.Q519H	ACH-002337	Lung Cancer	CCLE	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation altering degron motif	0.7582
p.P360L	ACH-000865	Esophageal Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1111
p.V413A	ACH-000874	Leukemia	CCLE	VSTST	DEG_SPOP_SBC_1	411:415	Mutation altering degron motif	0.6936
p.S402F	ACH-000884	Skin Cancer	CCLE	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0556
p.S402F	ACH-000884	Skin Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.0833
p.S402F	ACH-002159	Skin Cancer	CCLE	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0556
p.S402F	ACH-002159	Skin Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.0833
p.V583L	ACH-000890	Lung Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	586:590	Mutation rewiring degron network	0.25
p.P437T	ACH-000893	Lung Cancer	CCLE	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.2222
p.A755V	ACH-000939	Sarcoma	CCLE	VTTTT	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1111
p.R532H	ACH-000940	Endometrial/Uterine Cancer	CCLE	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.1111
p.R532H	ACH-001517	Endometrial/Uterine Cancer	CCLE	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.1111
p.M388I	ACH-000979	Prostate Cancer	CCLE	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation altering degron motif	0.7618
p.E580A	ACH-000986	Colon/Colorectal Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	586:590	Mutation rewiring degron network	0.1667
p.R471K	ACH-000987	Skin Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.25
p.D531N	ACH-000987	Skin Cancer	CCLE	LSTPTSS	DEG_SCF_FBW7_1	518:524	Mutation rewiring degron network	0.1389
p.E423D	ACH-000989	Colon/Colorectal Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1111
p.E423D	ACH-000989	Colon/Colorectal Cancer	CCLE	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1667
p.P267T	ACH-001377	Pancreatic Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1944
p.S679T	ACH-001490	Lung Cancer	CCLE	LSSTPVPS	DEG_SCF_FBW7_1	668:675	Mutation rewiring degron network	0.2222
p.L305F	ACH-001543	Head and Neck Cancer	CCLE	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1944
p.P433L	ACH-001550	Skin Cancer	CCLE	VTSTT	DEG_SPOP_SBC_1	429:433	Mutation altering degron motif	0.7582
p.P397L	ACH-001654	Esophageal Cancer	CCLE	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1944
p.P553L	ACH-002044	Head and Neck Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.25
p.M387V	ACH-002135	Lung Cancer	CCLE	VTTTT	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.3056
p.T301P	Saos-2	bone	COSMIC	LSSTPVLS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.3056
p.T2297I	JiyoyeP-2003	haematopoietic and lymphoid tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	2288:2292	Mutation rewiring degron network	0.1944
p.T2297I	LS-411N	large intestine	COSMIC	PSSTS	DEG_SPOP_SBC_1	2288:2292	Mutation rewiring degron network	0.1944
p.T2297I	TE-441-T	soft tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	2288:2292	Mutation rewiring degron network	0.1944
p.S412R	LB647-SCLC	lung	COSMIC	VSTST	DEG_SPOP_SBC_1	411:415	Mutation altering degron motif	0.6316
p.T406A	JHH-6	liver	COSMIC	VSTST	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1944
p.V2860A	RS4-11	haematopoietic and lymphoid tissue	COSMIC	VFTST	DEG_SPOP_SBC_1	2860:2864	Mutation altering degron motif	0.5825

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MUC3A

UniProt ID: Q02505

Entrez ID: 4584

Protein name: Mucin-3A (MUC-3A) (Intestinal mucin-3A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MUC3A in