DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SPOP_SBC_1

Location: 411:415

E3 ligase: SPOP

DEGRON score: 0.5581

ASA_SCORE: 89.1

COIL: 0.8954

CONS_SCORE: 0.4534

DSS_SCORE: 0.3557

HELIX: 0.0132

FCONS_SCORE: 1

RIG_SCORE: 0.7225

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V408A	TCGA-06-5416	GBM	TCGA	VSTST	DEG_SPOP_SBC_1	0.25
p.V408A	DO10880	GBM	ICGC	VSTST	DEG_SPOP_SBC_1	0.25
p.P409L	TCGA-14-3476	GBM	TCGA	VSTST	DEG_SPOP_SBC_1	0.2778
p.P409L	DO11417	GBM	ICGC	VSTST	DEG_SPOP_SBC_1	0.2778
p.S422I	TCGA-56-A62T	LUSC	TCGA	VSTST	DEG_SPOP_SBC_1	0.1389
p.S422I	DO219144	LUSC	ICGC	VSTST	DEG_SPOP_SBC_1	0.1389
p.S416I	TCGA-AJ-A5DW	UCEC	TCGA	VSTST	DEG_SPOP_SBC_1	0.3056
p.S416I	DO50075	UCEC	ICGC	VSTST	DEG_SPOP_SBC_1	0.3056
p.G406E	TCGA-B5-A3FC	UCEC	TCGA	VSTST	DEG_SPOP_SBC_1	0.1944
p.G406E	DO41871	UCEC	ICGC	VSTST	DEG_SPOP_SBC_1	0.1944
p.T405S	TCGA-CD-8529	STAD	TCGA	VSTST	DEG_SPOP_SBC_1	0.1667
p.T405S	DO47753	STAD	ICGC	VSTST	DEG_SPOP_SBC_1	0.1667
p.N411H	TCGA-EO-A22X	UCEC	TCGA	VSTST	DEG_SPOP_SBC_1	0.7423
p.N411H	DO43907	UCEC	ICGC	VSTST	DEG_SPOP_SBC_1	0.7423
p.V413I	TCGA-FR-A8YC	SKCM	TCGA	VSTST	DEG_SPOP_SBC_1	0.7076
p.V413I	DO220885	MELA	ICGC	VSTST	DEG_SPOP_SBC_1	0.7076
p.V413I	DO50301	SKCM	ICGC	VSTST	DEG_SPOP_SBC_1	0.7076
p.E423K	TCGA-G2-A2EF	BLCA	TCGA	VSTST	DEG_SPOP_SBC_1	0.1111
p.E423K	DO726	BLCA	ICGC	VSTST	DEG_SPOP_SBC_1	0.1111
p.G406R	DO233086	GACA	ICGC	VSTST	DEG_SPOP_SBC_1	0.1944
p.S416R	ACH-000631	Brain Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.3056
p.V413A	ACH-000874	Leukemia	CCLE	VSTST	DEG_SPOP_SBC_1	0.6936
p.S402F	ACH-000884	Skin Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.0833
p.S402F	ACH-002159	Skin Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.0833
p.E423D	ACH-000989	Colon/Colorectal Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.1111
p.S412R	LB647-SCLC	lung	COSMIC	VSTST	DEG_SPOP_SBC_1	0.6316
p.T406A	JHH-6	liver	COSMIC	VSTST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25686	DnaJ homolog subfamily B member 2	DEG_SPOP_SBC_1	167:171	VSTST	SPOP	0.9601	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	411:415	VSTST	SPOP	0.5581	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1163:1167	VSTST	SPOP	0.8721	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2452:2456	VSTST	SPOP	0.6432	More...
Q8WU58	Protein FAM222B	DEG_SPOP_SBC_1	244:248	VSTST	SPOP	0.9827	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5464:5468	VSTST	SPOP	0.9918	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5760:5764	VSTST	SPOP	0.9909	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6053:6057	VSTST	SPOP	0.9251	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8098:8102	VSTST	SPOP	0.9983	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8687:8691	VSTST	SPOP	0.979	More...
Q9ULH1	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	DEG_SPOP_SBC_1	776:780	VSTST	SPOP	0.9927	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2132:2136	VSTST	SPOP	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons