DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 5464:5468

E3 ligase: SPOP

DEGRON score: 0.9918

ASA_SCORE: 82

COIL: 0.8036

CONS_SCORE: 0

DSS_SCORE: 0.6168

HELIX: 0.012

FCONS_SCORE: 0

RIG_SCORE: 0.6465

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P5469S	TCGA-34-2596	LUSC	TCGA	VSTST	DEG_SPOP_SBC_1	0.3056
p.P5469S	DO26508	LUSC	ICGC	VSTST	DEG_SPOP_SBC_1	0.3056
p.Q5473H	TCGA-55-8301	LUAD	TCGA	VSTST	DEG_SPOP_SBC_1	0.1944
p.Q5473H	DO24682	LUAD	ICGC	VSTST	DEG_SPOP_SBC_1	0.1944
p.L5459M	TCGA-67-3770	LUAD	TCGA	VSTST	DEG_SPOP_SBC_1	0.1944
p.L5459M	DO23932	LUAD	ICGC	VSTST	DEG_SPOP_SBC_1	0.1944
p.I5471V	TCGA-BA-4076	HNSC	TCGA	VSTST	DEG_SPOP_SBC_1	0.25
p.I5471V	DO14502	HNSC	ICGC	VSTST	DEG_SPOP_SBC_1	0.25
p.P5469H	TCGA-DF-A2KU	UCEC	TCGA	VSTST	DEG_SPOP_SBC_1	0.3056
p.P5469H	DO223286	UCEC	ICGC	VSTST	DEG_SPOP_SBC_1	0.3056
p.S5465Y	TCGA-GV-A6ZA	BLCA	TCGA	VSTST	DEG_SPOP_SBC_1	0.712
p.S5465Y	DO49776	BLCA	ICGC	VSTST	DEG_SPOP_SBC_1	0.712
p.Q5473E	TCGA-JW-A5VJ	CESC	TCGA	VSTST	DEG_SPOP_SBC_1	0.1944
p.Q5473E	DO49974	CESC	ICGC	VSTST	DEG_SPOP_SBC_1	0.1944
p.T5458I	TCGA-W3-AA1O	SKCM	TCGA	VSTST	DEG_SPOP_SBC_1	0.1667
p.T5458I	DO51274	SKCM	ICGC	VSTST	DEG_SPOP_SBC_1	0.1667
p.T5468I	DO230309	COCA	ICGC	VSTST	DEG_SPOP_SBC_1	0.7078
p.Q5476H	DO222884	COCA	ICGC	VSTST	DEG_SPOP_SBC_1	0.1111
p.T5455I	SIDM00867	Glioblastoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.0833
p.T5455I	ACH-000863	Brain Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.0833
p.T5455I	DBTRG-05MG	central_nervous_system	COSMIC	VSTST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25686	DnaJ homolog subfamily B member 2	DEG_SPOP_SBC_1	167:171	VSTST	SPOP	0.9601	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	411:415	VSTST	SPOP	0.5581	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1163:1167	VSTST	SPOP	0.8721	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2452:2456	VSTST	SPOP	0.6432	More...
Q8WU58	Protein FAM222B	DEG_SPOP_SBC_1	244:248	VSTST	SPOP	0.9827	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5464:5468	VSTST	SPOP	0.9918	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5760:5764	VSTST	SPOP	0.9909	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6053:6057	VSTST	SPOP	0.9251	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8098:8102	VSTST	SPOP	0.9983	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8687:8691	VSTST	SPOP	0.979	More...
Q9ULH1	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	DEG_SPOP_SBC_1	776:780	VSTST	SPOP	0.9927	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2132:2136	VSTST	SPOP	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons