DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 5760:5764

E3 ligase: SPOP

DEGRON score: 0.9909

ASA_SCORE: 77.9

COIL: 0.765

CONS_SCORE: 0

DSS_SCORE: 0.446

HELIX: 0.0118

FCONS_SCORE: 0

RIG_SCORE: 0.7143

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R5771K	TCGA-B5-A11E	UCEC	TCGA	VSTST	DEG_SPOP_SBC_1	0.1389
p.R5771K	DO41644	UCEC	ICGC	VSTST	DEG_SPOP_SBC_1	0.1389
p.T5764P	TCGA-BR-4184	STAD	TCGA	VSTST	DEG_SPOP_SBC_1	0.7031
p.T5764P	TCGA-NQ-A57I	MESO	TCGA	VSTST	DEG_SPOP_SBC_1	0.7031
p.T5764P	DO38328	STAD	ICGC	VSTST	DEG_SPOP_SBC_1	0.7031
p.R5771I	TCGA-BS-A0UF	UCEC	TCGA	VSTST	DEG_SPOP_SBC_1	0.1389
p.R5771I	DO41488	UCEC	ICGC	VSTST	DEG_SPOP_SBC_1	0.1389
p.R5771I	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1389
p.R5771I	SIDM00118	Colorectal Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1389
p.R5771I	ACH-000744	Lung Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.1389
p.R5771I	ACH-001081	Colon/Colorectal Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.1389
p.R5771I	HCC2998	large_intestine	COSMIC	VSTST	DEG_SPOP_SBC_1	0.1389
p.R5771I	NCI-H1623	lung	COSMIC	VSTST	DEG_SPOP_SBC_1	0.1389
p.D5757N	TCGA-EE-A29V	SKCM	TCGA	VSTST	DEG_SPOP_SBC_1	0.25
p.D5757N	TCGA-EO-A22U	UCEC	TCGA	VSTST	DEG_SPOP_SBC_1	0.25
p.D5757N	DO38006	SKCM	ICGC	VSTST	DEG_SPOP_SBC_1	0.25
p.D5757N	DO43755	UCEC	ICGC	VSTST	DEG_SPOP_SBC_1	0.25
p.I5772S	TCGA-L5-A4ON	ESCA	TCGA	VSTST	DEG_SPOP_SBC_1	0.1111
p.I5772S	DO233206	GACA	ICGC	VSTST	DEG_SPOP_SBC_1	0.1111
p.I5751T	DO229010	COCA	ICGC	VSTST	DEG_SPOP_SBC_1	0.0833
p.I5751T	DO229013	COCA	ICGC	VSTST	DEG_SPOP_SBC_1	0.0833
p.I5751T	DO229016	COCA	ICGC	VSTST	DEG_SPOP_SBC_1	0.0833
p.I5751T	DO229003	COCA	ICGC	VSTST	DEG_SPOP_SBC_1	0.0833
p.I5751T	DO229005	COCA	ICGC	VSTST	DEG_SPOP_SBC_1	0.0833
p.A5754V	DO50402	ESAD	ICGC	VSTST	DEG_SPOP_SBC_1	0.1667
p.G5756E	SIDM00499	Prostate Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.2222
p.G5756E	ACH-000956	Prostate Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.2222
p.G5756E	22RV1	prostate	COSMIC	VSTST	DEG_SPOP_SBC_1	0.2222
p.P5765L	SIDM00855	Other Sarcomas	GDSC	VSTST	DEG_SPOP_SBC_1	0.3056
p.A5754T	SIDM00633	Breast Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1667
p.A5754T	SIDM00529	Breast Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1667
p.A5754T	SIDM00849	Kidney Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1667
p.A5754T	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1667
p.A5754T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1667
p.A5754T	SIDM00721	Small Cell Lung Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1667
p.A5754T	SIDM01409	Bladder Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1667
p.D5757G	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VSTST	DEG_SPOP_SBC_1	0.25
p.D5757G	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	VSTST	DEG_SPOP_SBC_1	0.25
p.T5774N	ACH-000884	Skin Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25686	DnaJ homolog subfamily B member 2	DEG_SPOP_SBC_1	167:171	VSTST	SPOP	0.9601	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	411:415	VSTST	SPOP	0.5581	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1163:1167	VSTST	SPOP	0.8721	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2452:2456	VSTST	SPOP	0.6432	More...
Q8WU58	Protein FAM222B	DEG_SPOP_SBC_1	244:248	VSTST	SPOP	0.9827	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5464:5468	VSTST	SPOP	0.9918	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5760:5764	VSTST	SPOP	0.9909	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6053:6057	VSTST	SPOP	0.9251	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8098:8102	VSTST	SPOP	0.9983	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8687:8691	VSTST	SPOP	0.979	More...
Q9ULH1	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	DEG_SPOP_SBC_1	776:780	VSTST	SPOP	0.9927	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2132:2136	VSTST	SPOP	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSTST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VSTST