DegronMD - P25686(DNAJB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R178H	TCGA-38-4625	LUAD	TCGA	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.R178H	DO52450	COCA	ICGC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.R178H	DO23952	LUAD	ICGC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.R178H	SIDM00660	Colorectal Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.R178H	SIDM00292	Small Cell Lung Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.R178H	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.R178H	ACH-000287	Lymphoma	CCLE	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.R178H	ACH-000985	Colon/Colorectal Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.R178H	ACH-002077	Lung Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.R178H	LU-165	lung	COSMIC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.R178H	LS-411N	large intestine	COSMIC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.R178H	NU-DUL-1	haematopoietic and lymphoid tissue	COSMIC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.R129P	TCGA-49-AAR2	LUAD	TCGA	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.2222
p.R129P	DO218918	LUAD	ICGC	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.2222
p.R178P	TCGA-62-A46O	LUAD	TCGA	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.R178P	DO26240	LUAD	ICGC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.G130C	TCGA-99-8025	LUAD	TCGA	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.1944
p.G130C	DO24255	LUAD	ICGC	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.1944
p.P159H	TCGA-A5-A0G1	UCEC	TCGA	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1111
p.P159H	DO42472	UCEC	ICGC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1111
p.P122L	TCGA-D3-A8GI	SKCM	TCGA	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation altering degron motif	0.6471
p.P122L	DO50284	SKCM	ICGC	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation altering degron motif	0.6471
p.R177C	TCGA-D5-6530	COAD	TCGA	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1667
p.R177C	DO8312	COAD	ICGC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1667
p.S134L	TCGA-DD-AADA	LIHC	TCGA	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.0833
p.S134L	DO52227	LIHC	ICGC	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.0833
p.S131F	TCGA-EE-A181	SKCM	TCGA	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.1667
p.S131F	DO37444	SKCM	ICGC	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.1667
p.G135V	TCGA-EO-A3B1	UCEC	TCGA	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.0556
p.G135V	DO52414	UCEC	ICGC	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.0556
p.Q175K	TCGA-FS-A1Z0	SKCM	TCGA	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.2222
p.Q175K	DO37431	SKCM	ICGC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.2222
p.R129W	TCGA-HU-A4H8	STAD	TCGA	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.2222
p.R129W	DO222800	COCA	ICGC	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.2222
p.R129W	DO47869	STAD	ICGC	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.2222
p.R177L	TCGA-KD-A5QT	SARC	TCGA	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1667
p.R177L	DO223271	SARC	ICGC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1667
p.P112R	TCGA-XF-A8HF	BLCA	TCGA	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.1111
p.P112R	DO49800	BLCA	ICGC	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.1111
p.Q127E	TCGA-XF-AAMG	BLCA	TCGA	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.2778
p.Q127E	DO219049	BLCA	ICGC	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.2778
p.R177H	DO233634	GACA	ICGC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1667
p.R178L	DO228985	LICA	ICGC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.S158I	DO229018	LICA	ICGC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0833
p.G135S	DO50970	LICA	ICGC	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.0556
p.R165H	DO232761	PBCA	ICGC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.2778
p.R165H	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.2778
p.R165H	ACH-000837	Lung Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.2778
p.R165H	NCI-H322M	lung	COSMIC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.2778
p.R165C	DO229502	SKCA	ICGC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.2778
p.R165C	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.2778
p.R165C	NCI-H2066	lung	COSMIC	VSTST	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.2778
p.L126P	SIDM01682	Gastric Carcinoma	GDSC	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.3056
p.L126P	ACH-000110	Gastric Cancer	CCLE	LGPFSE	LIG_APCC_ABBA_1	120:125	Mutation rewiring degron network	0.3056

Kaplan plot for DNAJB2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAJB2

UniProt ID: P25686

Entrez ID: 3300

Protein name: DnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNAJB2 in