DegronMD

Uniprot ID: P25686

Source protein: DnaJ homolog subfamily B member 2

Source gene: DNAJB2

Class: LIG_APCC_ABBA_1

Location: 120:125

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9367

ASA_SCORE: 44.45

COIL: 0.8

CONS_SCORE: 0.316

DSS_SCORE: 0.41

HELIX: 0.1233

FCONS_SCORE: 0.7623

RIG_SCORE: 0.7682

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R129P	TCGA-49-AAR2	LUAD	TCGA	LGPFSE	LIG_APCC_ABBA_1	0.2222
p.R129P	DO218918	LUAD	ICGC	LGPFSE	LIG_APCC_ABBA_1	0.2222
p.G130C	TCGA-99-8025	LUAD	TCGA	LGPFSE	LIG_APCC_ABBA_1	0.1944
p.G130C	DO24255	LUAD	ICGC	LGPFSE	LIG_APCC_ABBA_1	0.1944
p.P122L	TCGA-D3-A8GI	SKCM	TCGA	LGPFSE	LIG_APCC_ABBA_1	0.6471
p.P122L	DO50284	SKCM	ICGC	LGPFSE	LIG_APCC_ABBA_1	0.6471
p.S134L	TCGA-DD-AADA	LIHC	TCGA	LGPFSE	LIG_APCC_ABBA_1	0.0833
p.S134L	DO52227	LIHC	ICGC	LGPFSE	LIG_APCC_ABBA_1	0.0833
p.S131F	TCGA-EE-A181	SKCM	TCGA	LGPFSE	LIG_APCC_ABBA_1	0.1667
p.S131F	DO37444	SKCM	ICGC	LGPFSE	LIG_APCC_ABBA_1	0.1667
p.G135V	TCGA-EO-A3B1	UCEC	TCGA	LGPFSE	LIG_APCC_ABBA_1	0.0556
p.G135V	DO52414	UCEC	ICGC	LGPFSE	LIG_APCC_ABBA_1	0.0556
p.R129W	TCGA-HU-A4H8	STAD	TCGA	LGPFSE	LIG_APCC_ABBA_1	0.2222
p.R129W	DO222800	COCA	ICGC	LGPFSE	LIG_APCC_ABBA_1	0.2222
p.R129W	DO47869	STAD	ICGC	LGPFSE	LIG_APCC_ABBA_1	0.2222
p.P112R	TCGA-XF-A8HF	BLCA	TCGA	LGPFSE	LIG_APCC_ABBA_1	0.1111
p.P112R	DO49800	BLCA	ICGC	LGPFSE	LIG_APCC_ABBA_1	0.1111
p.Q127E	TCGA-XF-AAMG	BLCA	TCGA	LGPFSE	LIG_APCC_ABBA_1	0.2778
p.Q127E	DO219049	BLCA	ICGC	LGPFSE	LIG_APCC_ABBA_1	0.2778
p.G135S	DO50970	LICA	ICGC	LGPFSE	LIG_APCC_ABBA_1	0.0556
p.L126P	SIDM01682	Gastric Carcinoma	GDSC	LGPFSE	LIG_APCC_ABBA_1	0.3056
p.L126P	ACH-000110	Gastric Cancer	CCLE	LGPFSE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25686	DnaJ homolog subfamily B member 2	LIG_APCC_ABBA_1	120:125	LGPFSE	APC,CDC20,FZR1	0.9367	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons