DegronMD

Uniprot ID: P25686

Source protein: DnaJ homolog subfamily B member 2

Source gene: DNAJB2

Class: DEG_SPOP_SBC_1

Location: 167:171

E3 ligase: SPOP

DEGRON score: 0.9601

ASA_SCORE: 68.12

COIL: 0.5192

CONS_SCORE: 0.5895

DSS_SCORE: 0.4009

HELIX: 0.0098

FCONS_SCORE: 1.2673

RIG_SCORE: 0.7324

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R178H	TCGA-38-4625	LUAD	TCGA	VSTST	DEG_SPOP_SBC_1	0.1389
p.R178H	DO52450	COCA	ICGC	VSTST	DEG_SPOP_SBC_1	0.1389
p.R178H	DO23952	LUAD	ICGC	VSTST	DEG_SPOP_SBC_1	0.1389
p.R178H	SIDM00660	Colorectal Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1389
p.R178H	SIDM00292	Small Cell Lung Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1389
p.R178H	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1389
p.R178H	ACH-000287	Lymphoma	CCLE	VSTST	DEG_SPOP_SBC_1	0.1389
p.R178H	ACH-000985	Colon/Colorectal Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.1389
p.R178H	ACH-002077	Lung Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.1389
p.R178H	LU-165	lung	COSMIC	VSTST	DEG_SPOP_SBC_1	0.1389
p.R178H	LS-411N	large_intestine	COSMIC	VSTST	DEG_SPOP_SBC_1	0.1389
p.R178H	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	VSTST	DEG_SPOP_SBC_1	0.1389
p.R178P	TCGA-62-A46O	LUAD	TCGA	VSTST	DEG_SPOP_SBC_1	0.1389
p.R178P	DO26240	LUAD	ICGC	VSTST	DEG_SPOP_SBC_1	0.1389
p.P159H	TCGA-A5-A0G1	UCEC	TCGA	VSTST	DEG_SPOP_SBC_1	0.1111
p.P159H	DO42472	UCEC	ICGC	VSTST	DEG_SPOP_SBC_1	0.1111
p.R177C	TCGA-D5-6530	COAD	TCGA	VSTST	DEG_SPOP_SBC_1	0.1667
p.R177C	DO8312	COAD	ICGC	VSTST	DEG_SPOP_SBC_1	0.1667
p.Q175K	TCGA-FS-A1Z0	SKCM	TCGA	VSTST	DEG_SPOP_SBC_1	0.2222
p.Q175K	DO37431	SKCM	ICGC	VSTST	DEG_SPOP_SBC_1	0.2222
p.R177L	TCGA-KD-A5QT	SARC	TCGA	VSTST	DEG_SPOP_SBC_1	0.1667
p.R177L	DO223271	SARC	ICGC	VSTST	DEG_SPOP_SBC_1	0.1667
p.R177H	DO233634	GACA	ICGC	VSTST	DEG_SPOP_SBC_1	0.1667
p.R178L	DO228985	LICA	ICGC	VSTST	DEG_SPOP_SBC_1	0.1389
p.S158I	DO229018	LICA	ICGC	VSTST	DEG_SPOP_SBC_1	0.0833
p.R165H	DO232761	PBCA	ICGC	VSTST	DEG_SPOP_SBC_1	0.2778
p.R165H	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.2778
p.R165H	ACH-000837	Lung Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.2778
p.R165H	NCI-H322M	lung	COSMIC	VSTST	DEG_SPOP_SBC_1	0.2778
p.R165C	DO229502	SKCA	ICGC	VSTST	DEG_SPOP_SBC_1	0.2778
p.R165C	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.2778
p.R165C	NCI-H2066	lung	COSMIC	VSTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25686	DnaJ homolog subfamily B member 2	DEG_SPOP_SBC_1	167:171	VSTST	SPOP	0.9601	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	411:415	VSTST	SPOP	0.5581	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1163:1167	VSTST	SPOP	0.8721	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2452:2456	VSTST	SPOP	0.6432	More...
Q8WU58	Protein FAM222B	DEG_SPOP_SBC_1	244:248	VSTST	SPOP	0.9827	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5464:5468	VSTST	SPOP	0.9918	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5760:5764	VSTST	SPOP	0.9909	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6053:6057	VSTST	SPOP	0.9251	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8098:8102	VSTST	SPOP	0.9983	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8687:8691	VSTST	SPOP	0.979	More...
Q9ULH1	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	DEG_SPOP_SBC_1	776:780	VSTST	SPOP	0.9927	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2132:2136	VSTST	SPOP	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSTST

Degron related mutations and impact score

Drug responses associated with DNAJB2 mutations

All proteins holding degron of VSTST