DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VSTST
Uniprot ID:
Q02505
Source protein:
Mucin-3A
Source gene:
MUC3A
Class:
DEG_SPOP_SBC_1
Location:
1163:1167
E3 ligase:
SPOP
DEGRON score:
0.8721
ASA_SCORE:
90.88
COIL:
0.9294
CONS_SCORE:
0.4534
DSS_SCORE:
0.3442
HELIX:
0.0142
FCONS_SCORE:
1
RIG_SCORE:
0.738
Degron related mutations and impact score
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Mutation
Sample
Cancer
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Degron
Degron class
Impact score
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Drug responses associated with MUC3A mutations
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Mutation (In Degron?)
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All proteins holding degron of VSTST
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9ULH1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
DEG_SPOP_SBC_1
776:780
VSTST
SPOP
0.9927
More...
P25686
DnaJ homolog subfamily B member 2
DEG_SPOP_SBC_1
167:171
VSTST
SPOP
0.9601
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
5464:5468
VSTST
SPOP
0.9918
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Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
5760:5764
VSTST
SPOP
0.9909
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Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
6053:6057
VSTST
SPOP
0.9251
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Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
8098:8102
VSTST
SPOP
0.9983
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
8687:8691
VSTST
SPOP
0.979
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Q02505
Mucin-3A
DEG_SPOP_SBC_1
411:415
VSTST
SPOP
0.5581
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
1163:1167
VSTST
SPOP
0.8721
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
2452:2456
VSTST
SPOP
0.6432
More...
Q2M2H8
Probable maltase-glucoamylase 2
DEG_SPOP_SBC_1
2132:2136
VSTST
SPOP
0.998
More...
Q8WU58
Protein FAM222B
DEG_SPOP_SBC_1
244:248
VSTST
SPOP
0.9827
More...
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