DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 8687:8691

E3 ligase: SPOP

DEGRON score: 0.979

ASA_SCORE: 82.02

COIL: 0.8058

CONS_SCORE: 0

DSS_SCORE: 0.5999

HELIX: 0.0116

FCONS_SCORE: 0

RIG_SCORE: 0.6732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L8682P	TCGA-AD-6895	COAD	TCGA	VSTST	DEG_SPOP_SBC_1	0.1944
p.L8682P	DO8938	COAD	ICGC	VSTST	DEG_SPOP_SBC_1	0.1944
p.T8685R	TCGA-G9-6496	PRAD	TCGA	VSTST	DEG_SPOP_SBC_1	0.2778
p.T8685R	DO36344	PRAD	ICGC	VSTST	DEG_SPOP_SBC_1	0.2778
p.T8689R	TCGA-XF-A9T3	BLCA	TCGA	VSTST	DEG_SPOP_SBC_1	0.7876
p.T8689R	DO51922	BLCA	ICGC	VSTST	DEG_SPOP_SBC_1	0.7876
p.T8691P	DO233170	GACA	ICGC	VSTST	DEG_SPOP_SBC_1	0.7031
p.T8691P	DO49418	PACA	ICGC	VSTST	DEG_SPOP_SBC_1	0.7031
p.P8692T	DO233221	GACA	ICGC	VSTST	DEG_SPOP_SBC_1	0.3056
p.P8695Q	DO229035	LICA	ICGC	VSTST	DEG_SPOP_SBC_1	0.2222
p.A8693S	DO48689	LIRI	ICGC	VSTST	DEG_SPOP_SBC_1	0.2778
p.M8699I	DO220859	MELA	ICGC	VSTST	DEG_SPOP_SBC_1	0.1111
p.S8688P	SIDM01043	Other Sarcomas	GDSC	VSTST	DEG_SPOP_SBC_1	0.5641
p.S8688P	ACH-000913	Endometrial/Uterine Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.5641
p.S8688P	ESS-1	endometrium	COSMIC	VSTST	DEG_SPOP_SBC_1	0.5641
p.M8698V	SIDM01139	Pancreatic Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1389
p.M8698V	ACH-000042	Pancreatic Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.1389
p.M8698V	PANC-02-03	pancreas	COSMIC	VSTST	DEG_SPOP_SBC_1	0.1389
p.M8699V	SIDM00493	Other Solid Cancers	GDSC	VSTST	DEG_SPOP_SBC_1	0.1111
p.M8699V	SIDM00032	Bladder Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1111
p.M8699V	SIDM00621	Ewing's Sarcoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1111
p.M8699V	SIDM00954	Breast Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1111
p.V8687I	SIDM01086	B-Lymphoblastic Leukemia	GDSC	VSTST	DEG_SPOP_SBC_1	0.7076
p.V8687I	ACH-000874	Leukemia	CCLE	VSTST	DEG_SPOP_SBC_1	0.7076
p.V8687I	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	VSTST	DEG_SPOP_SBC_1	0.7076
p.M8698L	SIDM01693	B-Lymphoblastic Leukemia	GDSC	VSTST	DEG_SPOP_SBC_1	0.1389
p.M8698L	ACH-000032	Leukemia	CCLE	VSTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25686	DnaJ homolog subfamily B member 2	DEG_SPOP_SBC_1	167:171	VSTST	SPOP	0.9601	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	411:415	VSTST	SPOP	0.5581	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1163:1167	VSTST	SPOP	0.8721	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2452:2456	VSTST	SPOP	0.6432	More...
Q8WU58	Protein FAM222B	DEG_SPOP_SBC_1	244:248	VSTST	SPOP	0.9827	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5464:5468	VSTST	SPOP	0.9918	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5760:5764	VSTST	SPOP	0.9909	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6053:6057	VSTST	SPOP	0.9251	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8098:8102	VSTST	SPOP	0.9983	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8687:8691	VSTST	SPOP	0.979	More...
Q9ULH1	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	DEG_SPOP_SBC_1	776:780	VSTST	SPOP	0.9927	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2132:2136	VSTST	SPOP	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSTST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VSTST