DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
VSTST
Uniprot ID:
Q2M2H8
Source protein:
Probable maltase-glucoamylase 2
Source gene:
MGAM2
Class:
DEG_SPOP_SBC_1
Location:
2132:2136
E3 ligase:
SPOP
DEGRON score:
0.998
ASA_SCORE:
76.6
COIL:
0.7208
CONS_SCORE:
0
DSS_SCORE:
0.3947
HELIX:
0.024
FCONS_SCORE:
0
RIG_SCORE:
0.7735
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MGAM2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VSTST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P25686
DnaJ homolog subfamily B member 2
DEG_SPOP_SBC_1
167:171
VSTST
SPOP
0.9601
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
411:415
VSTST
SPOP
0.5581
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
1163:1167
VSTST
SPOP
0.8721
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
2452:2456
VSTST
SPOP
0.6432
More...
Q8WU58
Protein FAM222B
DEG_SPOP_SBC_1
244:248
VSTST
SPOP
0.9827
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
5464:5468
VSTST
SPOP
0.9918
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
5760:5764
VSTST
SPOP
0.9909
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
6053:6057
VSTST
SPOP
0.9251
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
8098:8102
VSTST
SPOP
0.9983
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
8687:8691
VSTST
SPOP
0.979
More...
Q9ULH1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
DEG_SPOP_SBC_1
776:780
VSTST
SPOP
0.9927
More...
Q2M2H8
Probable maltase-glucoamylase 2
DEG_SPOP_SBC_1
2132:2136
VSTST
SPOP
0.998
More...