DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 6053:6057

E3 ligase: SPOP

DEGRON score: 0.9251

ASA_SCORE: 77.4

COIL: 0.8274

CONS_SCORE: 0

DSS_SCORE: 0.7028

HELIX: 0.0084

FCONS_SCORE: 0

RIG_SCORE: 0.6269

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S6054Y	TCGA-29-1783	OV	TCGA	VSTST	DEG_SPOP_SBC_1	0.6009
p.S6054Y	DO28222	OV	ICGC	VSTST	DEG_SPOP_SBC_1	0.6009
p.N6065T	TCGA-A5-A2K5	UCEC	TCGA	VSTST	DEG_SPOP_SBC_1	0.1111
p.N6065T	DO41379	UCEC	ICGC	VSTST	DEG_SPOP_SBC_1	0.1111
p.S6046Y	TCGA-AX-A0J0	UCEC	TCGA	VSTST	DEG_SPOP_SBC_1	0.1389
p.S6046Y	DO41133	UCEC	ICGC	VSTST	DEG_SPOP_SBC_1	0.1389
p.S6054F	TCGA-BF-AAP2	SKCM	TCGA	VSTST	DEG_SPOP_SBC_1	0.6871
p.S6054F	DO219466	SKCM	ICGC	VSTST	DEG_SPOP_SBC_1	0.6871
p.S6046P	TCGA-HC-A6HY	PRAD	TCGA	VSTST	DEG_SPOP_SBC_1	0.1389
p.S6046P	DO49826	PRAD	ICGC	VSTST	DEG_SPOP_SBC_1	0.1389
p.P6061L	TCGA-W3-AA1V	SKCM	TCGA	VSTST	DEG_SPOP_SBC_1	0.2222
p.P6061L	DO51276	SKCM	ICGC	VSTST	DEG_SPOP_SBC_1	0.2222
p.S6060T	DO225360	BRCA	ICGC	VSTST	DEG_SPOP_SBC_1	0.25
p.M6047I	DO233277	GACA	ICGC	VSTST	DEG_SPOP_SBC_1	0.1667
p.E6049K	DO220891	MELA	ICGC	VSTST	DEG_SPOP_SBC_1	0.2222
p.S6060F	DO222653	MELA	ICGC	VSTST	DEG_SPOP_SBC_1	0.25
p.A6051T	DO46591	OV	ICGC	VSTST	DEG_SPOP_SBC_1	0.2778
p.A6051V	DO232761	PBCA	ICGC	VSTST	DEG_SPOP_SBC_1	0.2778
p.G6045E	DO229446	SKCA	ICGC	VSTST	DEG_SPOP_SBC_1	0.1111
p.T6063S	SIDM00499	Prostate Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1667
p.T6063S	ACH-000956	Prostate Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.1667
p.T6063S	22RV1	prostate	COSMIC	VSTST	DEG_SPOP_SBC_1	0.1667
p.D6050E	SIDM00128	Head and Neck Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.25
p.D6050E	ACH-002249	Head and Neck Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.25
p.D6050E	JHU-011	upper_aerodigestive_tract	COSMIC	VSTST	DEG_SPOP_SBC_1	0.25
p.E6062D	SIDM00255	Neuroblastoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1944
p.E6062D	ACH-002282	Neuroblastoma	CCLE	VSTST	DEG_SPOP_SBC_1	0.1944
p.E6062D	NB17	autonomic_ganglia	COSMIC	VSTST	DEG_SPOP_SBC_1	0.1944
p.M6048T	SIDM00681	Colorectal Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1944
p.M6048T	SIDM01641	Non-Cancerous	GDSC	VSTST	DEG_SPOP_SBC_1	0.1944
p.V6053I	SIDM00254	Neuroblastoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.7076
p.V6053I	SIDM00720	Mesothelioma	GDSC	VSTST	DEG_SPOP_SBC_1	0.7076
p.P6061S	SIDM01660	Kidney Carcinoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.2222
p.V6043D	ACH-000659	Lung Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.0556
p.V6043D	ACH-001386	Lung Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25686	DnaJ homolog subfamily B member 2	DEG_SPOP_SBC_1	167:171	VSTST	SPOP	0.9601	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	411:415	VSTST	SPOP	0.5581	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1163:1167	VSTST	SPOP	0.8721	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2452:2456	VSTST	SPOP	0.6432	More...
Q8WU58	Protein FAM222B	DEG_SPOP_SBC_1	244:248	VSTST	SPOP	0.9827	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5464:5468	VSTST	SPOP	0.9918	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5760:5764	VSTST	SPOP	0.9909	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6053:6057	VSTST	SPOP	0.9251	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8098:8102	VSTST	SPOP	0.9983	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8687:8691	VSTST	SPOP	0.979	More...
Q9ULH1	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	DEG_SPOP_SBC_1	776:780	VSTST	SPOP	0.9927	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2132:2136	VSTST	SPOP	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSTST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VSTST