DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 8098:8102

E3 ligase: SPOP

DEGRON score: 0.9983

ASA_SCORE: 78.24

COIL: 0.8166

CONS_SCORE: 0

DSS_SCORE: 0.5179

HELIX: 0.0114

FCONS_SCORE: 0

RIG_SCORE: 0.689

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G8104C	TCGA-56-A4BY	LUSC	TCGA	VSTST	DEG_SPOP_SBC_1	0.2778
p.G8104C	DO44802	LICA	ICGC	VSTST	DEG_SPOP_SBC_1	0.2778
p.G8104C	DO45457	LUSC	ICGC	VSTST	DEG_SPOP_SBC_1	0.2778
p.D8095Y	TCGA-85-6798	LUSC	TCGA	VSTST	DEG_SPOP_SBC_1	0.25
p.D8095Y	DO27295	LUSC	ICGC	VSTST	DEG_SPOP_SBC_1	0.25
p.R8110K	TCGA-E6-A1LX	UCEC	TCGA	VSTST	DEG_SPOP_SBC_1	0.1111
p.R8110K	TCGA-EE-A29D	SKCM	TCGA	VSTST	DEG_SPOP_SBC_1	0.1111
p.R8110K	DO38123	SKCM	ICGC	VSTST	DEG_SPOP_SBC_1	0.1111
p.R8110K	DO41020	UCEC	ICGC	VSTST	DEG_SPOP_SBC_1	0.1111
p.S8101L	TCGA-EE-A2GS	SKCM	TCGA	VSTST	DEG_SPOP_SBC_1	0.7667
p.S8101L	DO37465	SKCM	ICGC	VSTST	DEG_SPOP_SBC_1	0.7667
p.G8104S	TCGA-FR-A728	SKCM	TCGA	VSTST	DEG_SPOP_SBC_1	0.2778
p.G8104S	DO48550	SKCM	ICGC	VSTST	DEG_SPOP_SBC_1	0.2778
p.S8099C	TCGA-OR-A5L6	ACC	TCGA	VSTST	DEG_SPOP_SBC_1	0.643
p.T8102P	TCGA-R5-A805	STAD	TCGA	VSTST	DEG_SPOP_SBC_1	0.7031
p.T8102P	DO222346	STAD	ICGC	VSTST	DEG_SPOP_SBC_1	0.7031
p.M8093T	DO234321	ESAD	ICGC	VSTST	DEG_SPOP_SBC_1	0.1944
p.T8096S	DO234367	ESAD	ICGC	VSTST	DEG_SPOP_SBC_1	0.2778
p.S8099P	DO234413	ESAD	ICGC	VSTST	DEG_SPOP_SBC_1	0.5641
p.T8102N	DO228952	LICA	ICGC	VSTST	DEG_SPOP_SBC_1	0.7055
p.E8094K	DO222527	MELA	ICGC	VSTST	DEG_SPOP_SBC_1	0.2222
p.M8093V	SIDM00569	Osteosarcoma	GDSC	VSTST	DEG_SPOP_SBC_1	0.1944
p.M8093V	ACH-002178	Bone Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.1944
p.M8093V	NY	bone	COSMIC	VSTST	DEG_SPOP_SBC_1	0.1944
p.F8106S	SIDM01120	Other Solid Cancers	GDSC	VSTST	DEG_SPOP_SBC_1	0.2222
p.F8106S	ACH-002174	Lung Cancer	CCLE	VSTST	DEG_SPOP_SBC_1	0.2222
p.F8106S	NCI-H720	lung	COSMIC	VSTST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25686	DnaJ homolog subfamily B member 2	DEG_SPOP_SBC_1	167:171	VSTST	SPOP	0.9601	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	411:415	VSTST	SPOP	0.5581	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1163:1167	VSTST	SPOP	0.8721	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2452:2456	VSTST	SPOP	0.6432	More...
Q8WU58	Protein FAM222B	DEG_SPOP_SBC_1	244:248	VSTST	SPOP	0.9827	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5464:5468	VSTST	SPOP	0.9918	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5760:5764	VSTST	SPOP	0.9909	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6053:6057	VSTST	SPOP	0.9251	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8098:8102	VSTST	SPOP	0.9983	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8687:8691	VSTST	SPOP	0.979	More...
Q9ULH1	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	DEG_SPOP_SBC_1	776:780	VSTST	SPOP	0.9927	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2132:2136	VSTST	SPOP	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons