DegronMD - Q8WU58(FAM222B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V315I	TCGA-4R-AA8I	LIHC	TCGA	STRVSTHSVPTP	DEG_COP1_1	307:318	Mutation altering degron motif	0.7076
p.V315I	TCGA-4R-AA8I	LIHC	TCGA	VPTPMPS	DEG_SCF_FBW7_1	315:321	Mutation altering degron motif	0.5965
p.V315I	DO49657	LIHC	ICGC	STRVSTHSVPTP	DEG_COP1_1	307:318	Mutation altering degron motif	0.7076
p.V315I	DO49657	LIHC	ICGC	VPTPMPS	DEG_SCF_FBW7_1	315:321	Mutation altering degron motif	0.5965
p.V315I	SIDM00129	Melanoma	GDSC	STRVSTHSVPTP	DEG_COP1_1	307:318	Mutation altering degron motif	0.7076
p.V315I	SIDM00129	Melanoma	GDSC	VPTPMPS	DEG_SCF_FBW7_1	315:321	Mutation altering degron motif	0.5965
p.V315I	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	STRVSTHSVPTP	DEG_COP1_1	307:318	Mutation altering degron motif	0.7076
p.V315I	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VPTPMPS	DEG_SCF_FBW7_1	315:321	Mutation altering degron motif	0.5965
p.S311L	TCGA-A5-A0VP	UCEC	TCGA	STRVSTHSVPTP	DEG_COP1_1	307:318	Mutation altering degron motif	0.7667
p.S311L	DO42600	UCEC	ICGC	STRVSTHSVPTP	DEG_COP1_1	307:318	Mutation altering degron motif	0.7667
p.P240L	TCGA-AX-A2HD	UCEC	TCGA	VSTST	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2222
p.P240L	DO42608	UCEC	ICGC	VSTST	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2222
p.R309L	TCGA-CN-6010	HNSC	TCGA	STRVSTHSVPTP	DEG_COP1_1	307:318	Mutation altering degron motif	0.7316
p.R309L	DO14766	HNSC	ICGC	STRVSTHSVPTP	DEG_COP1_1	307:318	Mutation altering degron motif	0.7316
p.R300H	TCGA-D1-A1NZ	UCEC	TCGA	STRVSTHSVPTP	DEG_COP1_1	307:318	Mutation rewiring degron network	0.1389
p.R300H	TCGA-DU-6392	LGG	TCGA	STRVSTHSVPTP	DEG_COP1_1	307:318	Mutation rewiring degron network	0.1389
p.R300H	DO222762	COCA	ICGC	STRVSTHSVPTP	DEG_COP1_1	307:318	Mutation rewiring degron network	0.1389
p.R300H	DO22237	LGG	ICGC	STRVSTHSVPTP	DEG_COP1_1	307:318	Mutation rewiring degron network	0.1389
p.R300H	DO41536	UCEC	ICGC	STRVSTHSVPTP	DEG_COP1_1	307:318	Mutation rewiring degron network	0.1389
p.P240Q	TCGA-D3-A2JN	SKCM	TCGA	VSTST	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2222
p.P240Q	DO47590	SKCM	ICGC	VSTST	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2222
p.P92Q	TCGA-D3-A3C7	SKCM	TCGA	DTSAQRYSPYP	CBL_PTK	82:92	Mutation altering degron motif	0.7035
p.P92Q	DO47569	SKCM	ICGC	DTSAQRYSPYP	CBL_PTK	82:92	Mutation altering degron motif	0.7035
p.R75C	TCGA-E6-A1LX	UCEC	TCGA	DTSAQRYSPYP	CBL_PTK	82:92	Mutation rewiring degron network	0.1389
p.R75C	DO222699	MELA	ICGC	DTSAQRYSPYP	CBL_PTK	82:92	Mutation rewiring degron network	0.1389
p.R75C	DO41020	UCEC	ICGC	DTSAQRYSPYP	CBL_PTK	82:92	Mutation rewiring degron network	0.1389
p.R75C	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DTSAQRYSPYP	CBL_PTK	82:92	Mutation rewiring degron network	0.1389
p.R75C	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DTSAQRYSPYP	CBL_PTK	82:92	Mutation rewiring degron network	0.1389
p.S245F	TCGA-FI-A2D2	UCEC	TCGA	VSTST	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.6871
p.S245F	DO42065	UCEC	ICGC	VSTST	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.6871
p.H146Q	TCGA-GM-A2DH	BRCA	TCGA	APYATVAPS	DEG_SIAH_1	134:142	Mutation rewiring degron network	0.2222
p.H146Q	DO3317	BRCA	ICGC	APYATVAPS	DEG_SIAH_1	134:142	Mutation rewiring degron network	0.2222
p.S84L	TCGA-GM-A2DO	BRCA	TCGA	DTSAQRYSPYP	CBL_PTK	82:92	Mutation altering degron motif	0.6556
p.S84L	DO2037	BRCA	ICGC	DTSAQRYSPYP	CBL_PTK	82:92	Mutation altering degron motif	0.6556
p.P125S	TCGA-W3-A828	SKCM	TCGA	APYATVAPS	DEG_SIAH_1	134:142	Mutation rewiring degron network	0.0833
p.P125S	DO51273	SKCM	ICGC	APYATVAPS	DEG_SIAH_1	134:142	Mutation rewiring degron network	0.0833
p.A255D	DO51974	CLLE	ICGC	VSTST	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1389
p.P131T	DO228948	LICA	ICGC	APYATVAPS	DEG_SIAH_1	134:142	Mutation rewiring degron network	0.25
p.A140E	DO229015	LICA	ICGC	APYATVAPS	DEG_SIAH_1	134:142	Mutation altering degron motif	0.659
p.T77N	DO229015	LICA	ICGC	DTSAQRYSPYP	CBL_PTK	82:92	Mutation rewiring degron network	0.1944
p.T77N	NCI-H1755	lung	COSMIC	DTSAQRYSPYP	CBL_PTK	82:92	Mutation rewiring degron network	0.1944
p.A254E	DO229035	LICA	ICGC	VSTST	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1667
p.Q94K	DO229035	LICA	ICGC	DTSAQRYSPYP	CBL_PTK	82:92	Mutation rewiring degron network	0.2778
p.H73Q	DO232056	ORCA	ICGC	DTSAQRYSPYP	CBL_PTK	82:92	Mutation rewiring degron network	0.0833
p.Q148P	DO219881	SKCA	ICGC	APYATVAPS	DEG_SIAH_1	134:142	Mutation rewiring degron network	0.1667
p.Q148P	DO218888	SKCA	ICGC	APYATVAPS	DEG_SIAH_1	134:142	Mutation rewiring degron network	0.1667
p.V244G	SIDM00433	T-Lymphoblastic Leukemia	GDSC	VSTST	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.7532
p.V244G	ACH-000795	Leukemia	CCLE	VSTST	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.7532
p.V244G	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	VSTST	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.7532
p.E126K	SIDM00963	Breast Carcinoma	GDSC	APYATVAPS	DEG_SIAH_1	134:142	Mutation rewiring degron network	0.1111
p.E126K	ACH-000927	Breast Cancer	CCLE	APYATVAPS	DEG_SIAH_1	134:142	Mutation rewiring degron network	0.1111
p.E126K	BT-474	breast	COSMIC	APYATVAPS	DEG_SIAH_1	134:142	Mutation rewiring degron network	0.1111
p.A140T	SIDM00920	Breast Carcinoma	GDSC	APYATVAPS	DEG_SIAH_1	134:142	Mutation altering degron motif	0.6028
p.A140T	ACH-000783	Breast Cancer	CCLE	APYATVAPS	DEG_SIAH_1	134:142	Mutation altering degron motif	0.6028
p.A140T	CAMA-1	breast	COSMIC	APYATVAPS	DEG_SIAH_1	134:142	Mutation altering degron motif	0.6028
p.Y91S	ACH-000094	Pancreatic Cancer	CCLE	DTSAQRYSPYP	CBL_PTK	82:92	Mutation altering degron motif	0.6009
p.V74L	ACH-000887	Brain Cancer	CCLE	DTSAQRYSPYP	CBL_PTK	82:92	Mutation rewiring degron network	0.1111
p.R87H	ACH-000994	Endometrial/Uterine Cancer	CCLE	DTSAQRYSPYP	CBL_PTK	82:92	Mutation altering degron motif	0.7133
p.H146P	ACH-002181	Ovarian Cancer	CCLE	APYATVAPS	DEG_SIAH_1	134:142	Mutation rewiring degron network	0.2222
p.G309A	NCI-SNU-5	stomach	COSMIC	STRVSTHSVPTP	DEG_COP1_1	307:318	Mutation altering degron motif	0.754
p.P73H	Daudi	haematopoietic and lymphoid tissue	COSMIC	DTSAQRYSPYP	CBL_PTK	82:92	Mutation rewiring degron network	0.0833
p.T255M	TGBC1TKB	biliary tract	COSMIC	VSTST	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1389
p.L99V	OC-314	ovary	COSMIC	DTSAQRYSPYP	CBL_PTK	82:92	Mutation rewiring degron network	0.1389
p.A87T	Daudi	haematopoietic and lymphoid tissue	COSMIC	DTSAQRYSPYP	CBL_PTK	82:92	Mutation altering degron motif	0.7139
p.H95P	Daudi	haematopoietic and lymphoid tissue	COSMIC	DTSAQRYSPYP	CBL_PTK	82:92	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM222B

UniProt ID: Q8WU58

Entrez ID: 55731

Protein name: Protein FAM222B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM222B in