DegronMD

Uniprot ID: Q8WU58

Source protein: Protein FAM222B

Source gene: FAM222B

Class: DEG_SCF_FBW7_1

Location: 315:321

E3 ligase: FBXW7

DEGRON score: 0.9263

ASA_SCORE: 87.7286

COIL: 0.9469

CONS_SCORE: 0.6118

DSS_SCORE: 0.4755

HELIX: 0.0206

FCONS_SCORE: 0.9613

RIG_SCORE: 0.6625

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V315I	TCGA-4R-AA8I	LIHC	TCGA	VPTPMPS	DEG_SCF_FBW7_1	0.5965
p.V315I	DO49657	LIHC	ICGC	VPTPMPS	DEG_SCF_FBW7_1	0.5965
p.V315I	SIDM00129	Melanoma	GDSC	VPTPMPS	DEG_SCF_FBW7_1	0.5965
p.V315I	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VPTPMPS	DEG_SCF_FBW7_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WU58	Protein FAM222B	DEG_SCF_FBW7_1	315:321	VPTPMPS	FBXW7	0.9263	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons