DegronMD

Uniprot ID: Q8WU58

Source protein: Protein FAM222B

Source gene: FAM222B

Class: DEG_COP1_1

Location: 307:318

E3 ligase: COP1

DEGRON score: 0.973

ASA_SCORE: 94.3167

COIL: 0.9359

CONS_SCORE: 0.659

DSS_SCORE: 0.4473

HELIX: 0.0219

FCONS_SCORE: 0.9221

RIG_SCORE: 0.6641

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V315I	TCGA-4R-AA8I	LIHC	TCGA	STRVSTHSVPTP	DEG_COP1_1	0.7076
p.V315I	DO49657	LIHC	ICGC	STRVSTHSVPTP	DEG_COP1_1	0.7076
p.V315I	SIDM00129	Melanoma	GDSC	STRVSTHSVPTP	DEG_COP1_1	0.7076
p.V315I	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	STRVSTHSVPTP	DEG_COP1_1	0.7076
p.S311L	TCGA-A5-A0VP	UCEC	TCGA	STRVSTHSVPTP	DEG_COP1_1	0.7667
p.S311L	DO42600	UCEC	ICGC	STRVSTHSVPTP	DEG_COP1_1	0.7667
p.R309L	TCGA-CN-6010	HNSC	TCGA	STRVSTHSVPTP	DEG_COP1_1	0.7316
p.R309L	DO14766	HNSC	ICGC	STRVSTHSVPTP	DEG_COP1_1	0.7316
p.R300H	TCGA-D1-A1NZ	UCEC	TCGA	STRVSTHSVPTP	DEG_COP1_1	0.1389
p.R300H	TCGA-DU-6392	LGG	TCGA	STRVSTHSVPTP	DEG_COP1_1	0.1389
p.R300H	DO222762	COCA	ICGC	STRVSTHSVPTP	DEG_COP1_1	0.1389
p.R300H	DO22237	LGG	ICGC	STRVSTHSVPTP	DEG_COP1_1	0.1389
p.R300H	DO41536	UCEC	ICGC	STRVSTHSVPTP	DEG_COP1_1	0.1389
p.G309A	NCI-SNU-5	stomach	COSMIC	STRVSTHSVPTP	DEG_COP1_1	0.754

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WU58	Protein FAM222B	DEG_COP1_1	307:318	STRVSTHSVPTP	COP1	0.973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons