DegronMD

Uniprot ID: Q8WU58

Source protein: Protein FAM222B

Source gene: FAM222B

Class: DEG_SIAH_1

Location: 134:142

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9609

ASA_SCORE: 81.8111

COIL: 0.9236

CONS_SCORE: 0.6885

DSS_SCORE: 0.4047

HELIX: 0.0478

FCONS_SCORE: 0.9106

RIG_SCORE: 0.7326

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H146Q	TCGA-GM-A2DH	BRCA	TCGA	APYATVAPS	DEG_SIAH_1	0.2222
p.H146Q	DO3317	BRCA	ICGC	APYATVAPS	DEG_SIAH_1	0.2222
p.P125S	TCGA-W3-A828	SKCM	TCGA	APYATVAPS	DEG_SIAH_1	0.0833
p.P125S	DO51273	SKCM	ICGC	APYATVAPS	DEG_SIAH_1	0.0833
p.P131T	DO228948	LICA	ICGC	APYATVAPS	DEG_SIAH_1	0.25
p.A140E	DO229015	LICA	ICGC	APYATVAPS	DEG_SIAH_1	0.659
p.Q148P	DO219881	SKCA	ICGC	APYATVAPS	DEG_SIAH_1	0.1667
p.Q148P	DO218888	SKCA	ICGC	APYATVAPS	DEG_SIAH_1	0.1667
p.E126K	SIDM00963	Breast Carcinoma	GDSC	APYATVAPS	DEG_SIAH_1	0.1111
p.E126K	ACH-000927	Breast Cancer	CCLE	APYATVAPS	DEG_SIAH_1	0.1111
p.E126K	BT-474	breast	COSMIC	APYATVAPS	DEG_SIAH_1	0.1111
p.A140T	SIDM00920	Breast Carcinoma	GDSC	APYATVAPS	DEG_SIAH_1	0.6028
p.A140T	ACH-000783	Breast Cancer	CCLE	APYATVAPS	DEG_SIAH_1	0.6028
p.A140T	CAMA-1	breast	COSMIC	APYATVAPS	DEG_SIAH_1	0.6028
p.H146P	ACH-002181	Ovarian Cancer	CCLE	APYATVAPS	DEG_SIAH_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WU58	Protein FAM222B	DEG_SIAH_1	134:142	APYATVAPS	SIAH1,SIAH2,SIAH3	0.9609	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons