DegronMD

Uniprot ID: Q8WU58

Source protein: Protein FAM222B

Source gene: FAM222B

Class: CBL_PTK

Location: 82:92

E3 ligase: CBL

DEGRON score: 0.9693

ASA_SCORE: 85.2182

COIL: 0.843

CONS_SCORE: 0.9446

DSS_SCORE: 0.4678

HELIX: 0.1036

FCONS_SCORE: 1.0791

RIG_SCORE: 0.7462

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P92Q	TCGA-D3-A3C7	SKCM	TCGA	DTSAQRYSPYP	CBL_PTK	0.7035
p.P92Q	DO47569	SKCM	ICGC	DTSAQRYSPYP	CBL_PTK	0.7035
p.R75C	TCGA-E6-A1LX	UCEC	TCGA	DTSAQRYSPYP	CBL_PTK	0.1389
p.R75C	DO222699	MELA	ICGC	DTSAQRYSPYP	CBL_PTK	0.1389
p.R75C	DO41020	UCEC	ICGC	DTSAQRYSPYP	CBL_PTK	0.1389
p.R75C	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DTSAQRYSPYP	CBL_PTK	0.1389
p.R75C	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	DTSAQRYSPYP	CBL_PTK	0.1389
p.S84L	TCGA-GM-A2DO	BRCA	TCGA	DTSAQRYSPYP	CBL_PTK	0.6556
p.S84L	DO2037	BRCA	ICGC	DTSAQRYSPYP	CBL_PTK	0.6556
p.T77N	DO229015	LICA	ICGC	DTSAQRYSPYP	CBL_PTK	0.1944
p.T77N	NCI-H1755	lung	COSMIC	DTSAQRYSPYP	CBL_PTK	0.1944
p.Q94K	DO229035	LICA	ICGC	DTSAQRYSPYP	CBL_PTK	0.2778
p.H73Q	DO232056	ORCA	ICGC	DTSAQRYSPYP	CBL_PTK	0.0833
p.Y91S	ACH-000094	Pancreatic Cancer	CCLE	DTSAQRYSPYP	CBL_PTK	0.6009
p.V74L	ACH-000887	Brain Cancer	CCLE	DTSAQRYSPYP	CBL_PTK	0.1111
p.R87H	ACH-000994	Endometrial/Uterine Cancer	CCLE	DTSAQRYSPYP	CBL_PTK	0.7133
p.P73H	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DTSAQRYSPYP	CBL_PTK	0.0833
p.L99V	OC-314	ovary	COSMIC	DTSAQRYSPYP	CBL_PTK	0.1389
p.A87T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DTSAQRYSPYP	CBL_PTK	0.7139
p.H95P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DTSAQRYSPYP	CBL_PTK	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WU58	Protein FAM222B	CBL_PTK	82:92	DTSAQRYSPYP	CBL	0.9693	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons