DegronMD

Uniprot ID: Q9ULH1

Source protein: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

Source gene: ASAP1

Class: DEG_SPOP_SBC_1

Location: 776:780

E3 ligase: SPOP

DEGRON score: 0.9927

ASA_SCORE: 68.84

COIL: 0.746

CONS_SCORE: 0.2376

DSS_SCORE: 0.5796

HELIX: 0.0286

FCONS_SCORE: 0.9407

RIG_SCORE: 0.6899

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E789K	TCGA-AC-A23H	BRCA	TCGA	VSTST	DEG_SPOP_SBC_1	0.0833
p.E789K	DO2401	BRCA	ICGC	VSTST	DEG_SPOP_SBC_1	0.0833
p.V776I	TCGA-MX-A5UJ	STAD	TCGA	VSTST	DEG_SPOP_SBC_1	0.7076
p.V776I	DO48547	STAD	ICGC	VSTST	DEG_SPOP_SBC_1	0.7076
p.S779R	DO229045	LICA	ICGC	VSTST	DEG_SPOP_SBC_1	0.7427
p.T788M	DO35442	PACA	ICGC	VSTST	DEG_SPOP_SBC_1	0.1111
p.S782L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VSTST	DEG_SPOP_SBC_1	0.2778
p.S782L	ACH-002256	Leukemia	CCLE	VSTST	DEG_SPOP_SBC_1	0.2778
p.S782L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VSTST	DEG_SPOP_SBC_1	0.2778
p.S775L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VSTST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25686	DnaJ homolog subfamily B member 2	DEG_SPOP_SBC_1	167:171	VSTST	SPOP	0.9601	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	411:415	VSTST	SPOP	0.5581	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1163:1167	VSTST	SPOP	0.8721	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2452:2456	VSTST	SPOP	0.6432	More...
Q8WU58	Protein FAM222B	DEG_SPOP_SBC_1	244:248	VSTST	SPOP	0.9827	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5464:5468	VSTST	SPOP	0.9918	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5760:5764	VSTST	SPOP	0.9909	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6053:6057	VSTST	SPOP	0.9251	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8098:8102	VSTST	SPOP	0.9983	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8687:8691	VSTST	SPOP	0.979	More...
Q9ULH1	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	DEG_SPOP_SBC_1	776:780	VSTST	SPOP	0.9927	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2132:2136	VSTST	SPOP	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons