DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SCF_FBW7_1

Location: 2699:2704

E3 ligase: FBXW7

DEGRON score: 0.9674

ASA_SCORE: 99.2667

COIL: 0.9188

CONS_SCORE: 0

DSS_SCORE: 0.3031

HELIX: 0.0148

FCONS_SCORE: 0

RIG_SCORE: 0.7479

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2709Y	SIDM00428	Acute Myeloid Leukemia	GDSC	ITPVFS	DEG_SCF_FBW7_1	0.1944
p.S2709Y	SIDM00672	Hepatocellular Carcinoma	GDSC	ITPVFS	DEG_SCF_FBW7_1	0.1944
p.S2709Y	SIDM00393	Gastric Carcinoma	GDSC	ITPVFS	DEG_SCF_FBW7_1	0.1944
p.S2709Y	SIDM00118	Colorectal Carcinoma	GDSC	ITPVFS	DEG_SCF_FBW7_1	0.1944
p.S2712F	SIDM00447	B-Lymphoblastic Leukemia	GDSC	ITPVFS	DEG_SCF_FBW7_1	0.1111
p.S2712F	REH	haematopoietic_and_lymphoid_tissue	COSMIC	ITPVFS	DEG_SCF_FBW7_1	0.1111
p.I2707V	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	ITPVFS	DEG_SCF_FBW7_1	0.25
p.I2707V	HCE-4	oesophagus	COSMIC	ITPVFS	DEG_SCF_FBW7_1	0.25
p.P2711S	SIDM00801	Melanoma	GDSC	ITPVFS	DEG_SCF_FBW7_1	0.1389
p.P2711S	A101D	skin	COSMIC	ITPVFS	DEG_SCF_FBW7_1	0.1389
p.S2695P	SIDM00011	Melanoma	GDSC	ITPVFS	DEG_SCF_FBW7_1	0.2222
p.P2701L	SIDM01451	Pancreatic Carcinoma	GDSC	ITPVFS	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SCF_FBW7_1	2699:2704	ITPVFS	FBXW7	0.9674	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons