DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ITPTNT
Uniprot ID:
Q02505
Source protein:
Mucin-3A
Source gene:
MUC3A
Class:
DEG_SCF_FBW7_1
Location:
1014:1019
E3 ligase:
FBXW7
DEGRON score:
0.8036
ASA_SCORE:
96.3833
COIL:
0.9165
CONS_SCORE:
0.4534
DSS_SCORE:
0.5876
HELIX:
0.0157
FCONS_SCORE:
1
RIG_SCORE:
0.6921
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T1015I
SIDM00095
Glioblastoma
GDSC
ITPTNT
DEG_SCF_FBW7_1
0.7078
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Drug responses associated with MUC3A mutations
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Cancer
Mutation (In Degron?)
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Drug
IC50
No data available in table
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All proteins holding degron of ITPTNT
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q02505
Mucin-3A
DEG_SCF_FBW7_1
1014:1019
ITPTNT
FBXW7
0.8036
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