DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SCF_FBW7_1

Location: 668:675

E3 ligase: FBXW7

DEGRON score: 0.5452

ASA_SCORE: 90.4

COIL: 0.9426

CONS_SCORE: 0.4534

DSS_SCORE: 0.4912

HELIX: 0.01

FCONS_SCORE: 1

RIG_SCORE: 0.6707

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D678Y	TCGA-43-A56V	LUSC	TCGA	LSSTPVPS	DEG_SCF_FBW7_1	0.25
p.D678Y	DO45535	LUSC	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.25
p.T660I	TCGA-4Z-AA86	BLCA	TCGA	LSSTPVPS	DEG_SCF_FBW7_1	0.1111
p.T660I	DO218989	BLCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.1111
p.T660I	DO220900	MELA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.1111
p.T660N	TCGA-51-4081	LUSC	TCGA	LSSTPVPS	DEG_SCF_FBW7_1	0.1111
p.T660N	DO26544	LUSC	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.1111
p.K685N	TCGA-80-5608	LUAD	TCGA	LSSTPVPS	DEG_SCF_FBW7_1	0.0556
p.K685N	DO23693	LUAD	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.0556
p.A669V	TCGA-EJ-7782	PRAD	TCGA	LSSTPVPS	DEG_SCF_FBW7_1	0.6936
p.A669V	DO36256	PRAD	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.6936
p.C676Y	TCGA-EO-A3AU	UCEC	TCGA	LSSTPVPS	DEG_SCF_FBW7_1	0.3056
p.C676Y	DO43827	UCEC	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.3056
p.S679F	TCGA-WE-A8K5	SKCM	TCGA	LSSTPVPS	DEG_SCF_FBW7_1	0.2222
p.S679F	DO51282	SKCM	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.2222
p.A673V	DO224721	COCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.6936
p.A673V	DO222760	COCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.6936
p.A673V	DO222853	COCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.6936
p.A673V	DO229010	COCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.6936
p.A673V	DO229013	COCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.6936
p.A673V	DO229016	COCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.6936
p.A673V	DO229003	COCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.6936
p.A673V	DO229005	COCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.6936
p.A673V	DO230659	LAML	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.6936
p.A673V	DO50989	LAML	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.6936
p.A673V	DO231140	LAML	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.6936
p.A673V	DO218847	SKCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.6936
p.A673V	DO229221	THCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.6936
p.T661M	DO222709	COCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.1389
p.T661M	DO233873	GACA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.1389
p.T661M	DO231220	LAML	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.1389
p.A669T	DO233261	GACA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.7139
p.T660S	DO46354	OV	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.1111
p.S670N	DO51528	PACA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.5958
p.N674T	DO232224	PBCA	ICGC	LSSTPVPS	DEG_SCF_FBW7_1	0.7055
p.Q671E	ACH-000069	Lymphoma	CCLE	LSSTPVPS	DEG_SCF_FBW7_1	0.6744
p.S679T	ACH-001490	Lung Cancer	CCLE	LSSTPVPS	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSSTPVPS

Degron related mutations and impact score

Drug responses associated with MUC3A mutations

All proteins holding degron of LSSTPVPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SCF_FBW7_1	668:675	LSSTPVPS	FBXW7	0.5452	More...
Q02505	Mucin-3A	DEG_SCF_FBW7_1	1044:1051	LSSTPVPS	FBXW7	0.6291	More...