DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SCF_FBW7_1

Location: 696:702

E3 ligase: FBXW7

DEGRON score: 0.7658

ASA_SCORE: 94.0714

COIL: 0.943

CONS_SCORE: 0.4534

DSS_SCORE: 0.5543

HELIX: 0.014

FCONS_SCORE: 1

RIG_SCORE: 0.6912

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A703D	TCGA-33-4583	LUSC	TCGA	LPTPNAS	DEG_SCF_FBW7_1	0.3056
p.A703D	DO27112	LUSC	ICGC	LPTPNAS	DEG_SCF_FBW7_1	0.3056
p.A709T	TCGA-AP-A1DV	UCEC	TCGA	LPTPNAS	DEG_SCF_FBW7_1	0.1389
p.A709T	DO43186	UCEC	ICGC	LPTPNAS	DEG_SCF_FBW7_1	0.1389
p.P710L	TCGA-NJ-A4YQ	LUAD	TCGA	LPTPNAS	DEG_SCF_FBW7_1	0.1111
p.P710L	DO218944	LUAD	ICGC	LPTPNAS	DEG_SCF_FBW7_1	0.1111
p.G712D	DO224708	COCA	ICGC	LPTPNAS	DEG_SCF_FBW7_1	0.0556
p.E702A	DO222560	COCA	ICGC	LPTPNAS	DEG_SCF_FBW7_1	0.7701
p.E702A	DO222813	COCA	ICGC	LPTPNAS	DEG_SCF_FBW7_1	0.7701
p.E702A	DO229010	COCA	ICGC	LPTPNAS	DEG_SCF_FBW7_1	0.7701
p.E702A	DO229013	COCA	ICGC	LPTPNAS	DEG_SCF_FBW7_1	0.7701
p.E702A	DO229016	COCA	ICGC	LPTPNAS	DEG_SCF_FBW7_1	0.7701
p.E702A	DO229003	COCA	ICGC	LPTPNAS	DEG_SCF_FBW7_1	0.7701
p.E702A	DO229005	COCA	ICGC	LPTPNAS	DEG_SCF_FBW7_1	0.7701
p.C705Y	ACH-000723	Head and Neck Cancer	CCLE	LPTPNAS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SCF_FBW7_1	696:702	LPTPNAS	FBXW7	0.7658	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons