DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SPOP_SBC_1

Location: 190:194

E3 ligase: SPOP

DEGRON score: 0.7312

ASA_SCORE: 90.4

COIL: 0.9222

CONS_SCORE: 0.4534

DSS_SCORE: 0.6085

HELIX: 0.0168

FCONS_SCORE: 1

RIG_SCORE: 0.6725

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E180D	TCGA-A5-A2K5	UCEC	TCGA	PSTTT	DEG_SPOP_SBC_1	0.0556
p.E180D	DO41379	UCEC	ICGC	PSTTT	DEG_SPOP_SBC_1	0.0556
p.Q193K	TCGA-C5-A7UI	CESC	TCGA	PSTTT	DEG_SPOP_SBC_1	0.6944
p.Q193K	DO49892	CESC	ICGC	PSTTT	DEG_SPOP_SBC_1	0.6944
p.T195N	TCGA-P5-A5EV	LGG	TCGA	PSTTT	DEG_SPOP_SBC_1	0.3056
p.T195N	DO50160	LGG	ICGC	PSTTT	DEG_SPOP_SBC_1	0.3056
p.S200L	TCGA-PE-A5DE	BRCA	TCGA	PSTTT	DEG_SPOP_SBC_1	0.1667
p.S200L	DO219643	BRCA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.1667
p.T183M	DO224645	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.1389
p.V182F	DO222822	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.1111
p.V182F	DO229010	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.1111
p.V182F	DO229013	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.1111
p.V182F	DO229016	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.1111
p.V182F	DO229003	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.1111
p.V182F	DO229005	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.1111
p.V182F	DO229211	THCA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.1111
p.T198I	DO229010	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.6667
p.T198I	DO229013	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.6667
p.T198I	DO229016	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.6667
p.T198I	DO229003	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.6667
p.T198I	DO229005	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.6667
p.P199S	DO220889	MELA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.1944
p.P183S	DO229453	SKCA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.1389
p.T204A	SIDM01039	Other Solid Cancers	GDSC	PSTTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	190:194	PSTTT	SPOP	0.7312	More...
Q49MG5	Microtubule-associated protein 9	DEG_SPOP_SBC_1	391:395	PSTTT	SPOP	0.8944	More...
Q9H2E6	Semaphorin-6A	DEG_SPOP_SBC_1	584:588	PSTTT	SPOP	0.5391	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	190:194	PSTTT	SPOP	0.8903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons