DegronMD

Uniprot ID: Q9H2E6

Source protein: Semaphorin-6A

Source gene: SEMA6A

Class: DEG_SPOP_SBC_1

Location: 584:588

E3 ligase: SPOP

DEGRON score: 0.5391

ASA_SCORE: 63.1

COIL: 0.7348

CONS_SCORE: 0.3925

DSS_SCORE: 0.6056

HELIX: 0.0312

FCONS_SCORE: 1.0136

RIG_SCORE: 0.6568

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S591L	TCGA-AN-A046	BRCA	TCGA	PSTTT	DEG_SPOP_SBC_1	0.25
p.S591L	DO1285	BRCA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.25
p.A574T	TCGA-AX-A2HD	UCEC	TCGA	PSTTT	DEG_SPOP_SBC_1	0.0556
p.A574T	DO42608	UCEC	ICGC	PSTTT	DEG_SPOP_SBC_1	0.0556
p.P584H	TCGA-D8-A1JA	BRCA	TCGA	PSTTT	DEG_SPOP_SBC_1	0.7694
p.P584H	DO2819	BRCA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.7694
p.T587S	TCGA-DU-7309	LGG	TCGA	PSTTT	DEG_SPOP_SBC_1	0.6005
p.T587S	DO22762	LGG	ICGC	PSTTT	DEG_SPOP_SBC_1	0.6005
p.S588Y	DO48991	CESC	ICGC	PSTTT	DEG_SPOP_SBC_1	0.712
p.T586K	DO229025	LICA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.7306
p.T586K	DO229009	LICA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.7306
p.P584T	DO229031	LICA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.7031
p.A574E	DO229036	LICA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	190:194	PSTTT	SPOP	0.7312	More...
Q49MG5	Microtubule-associated protein 9	DEG_SPOP_SBC_1	391:395	PSTTT	SPOP	0.8944	More...
Q9H2E6	Semaphorin-6A	DEG_SPOP_SBC_1	584:588	PSTTT	SPOP	0.5391	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	190:194	PSTTT	SPOP	0.8903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons