DegronMD - Q9H2E6(SEMA6A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M727I	TCGA-17-Z062	LUAD	TCGA	LATPGNT	DEG_SCF_FBW7_1	732:738	Mutation rewiring degron network	0.1944
p.P1012S	TCGA-4T-AA8H	COAD	TCGA	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation rewiring degron network	0.1667
p.P1012S	DO51724	COAD	ICGC	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation rewiring degron network	0.1667
p.P756L	TCGA-64-5774	LUAD	TCGA	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation altering degron motif	0.6471
p.P756L	DO24770	LUAD	ICGC	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation altering degron motif	0.6471
p.D751Y	TCGA-A5-A0G2	UCEC	TCGA	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.2222
p.D751Y	DO41235	UCEC	ICGC	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.2222
p.A1028V	TCGA-A5-A1OF	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation rewiring degron network	0.1667
p.A1028V	DO221545	PACA	ICGC	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation rewiring degron network	0.1667
p.A1028V	DO42568	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation rewiring degron network	0.1667
p.T761A	TCGA-A6-5661	COAD	TCGA	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation altering degron motif	0.7139
p.T761A	DO8634	COAD	ICGC	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation altering degron motif	0.7139
p.S591L	TCGA-AN-A046	BRCA	TCGA	PSTTT	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.25
p.S591L	DO1285	BRCA	ICGC	PSTTT	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.25
p.K740R	TCGA-AP-A059	UCEC	TCGA	LATPGNT	DEG_SCF_FBW7_1	732:738	Mutation rewiring degron network	0.2778
p.K740R	DO41361	UCEC	ICGC	LATPGNT	DEG_SCF_FBW7_1	732:738	Mutation rewiring degron network	0.2778
p.S1022Y	TCGA-AP-A1DK	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation altering degron motif	0.712
p.S1022Y	DO42033	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation altering degron motif	0.712
p.A574T	TCGA-AX-A2HD	UCEC	TCGA	PSTTT	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.0556
p.A574T	DO42608	UCEC	ICGC	PSTTT	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.0556
p.P758L	TCGA-BR-8485	STAD	TCGA	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation altering degron motif	0.7582
p.P758L	DO47823	STAD	ICGC	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation altering degron motif	0.7582
p.P584H	TCGA-D8-A1JA	BRCA	TCGA	PSTTT	DEG_SPOP_SBC_1	584:588	Mutation altering degron motif	0.7694
p.P584H	DO2819	BRCA	ICGC	PSTTT	DEG_SPOP_SBC_1	584:588	Mutation altering degron motif	0.7694
p.K1024E	TCGA-DI-A1BU	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation rewiring degron network	0.2778
p.K1024E	DO42023	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation rewiring degron network	0.2778
p.T587S	TCGA-DU-7309	LGG	TCGA	PSTTT	DEG_SPOP_SBC_1	584:588	Mutation altering degron motif	0.6005
p.T587S	DO22762	LGG	ICGC	PSTTT	DEG_SPOP_SBC_1	584:588	Mutation altering degron motif	0.6005
p.F384L	TCGA-EO-A22U	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0556
p.F384L	DO43755	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0556
p.A754V	TCGA-ER-A3PL	SKCM	TCGA	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.3056
p.A754V	DO37495	SKCM	ICGC	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.3056
p.A745S	TCGA-F1-6874	STAD	TCGA	LATPGNT	DEG_SCF_FBW7_1	732:738	Mutation rewiring degron network	0.1389
p.A745S	TCGA-F1-6874	STAD	TCGA	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.0556
p.A745S	TCGA-Q1-A5R2	CESC	TCGA	LATPGNT	DEG_SCF_FBW7_1	732:738	Mutation rewiring degron network	0.1389
p.A745S	TCGA-Q1-A5R2	CESC	TCGA	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.0556
p.A745S	DO49003	CESC	ICGC	LATPGNT	DEG_SCF_FBW7_1	732:738	Mutation rewiring degron network	0.1389
p.A745S	DO49003	CESC	ICGC	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.0556
p.A745S	DO38201	STAD	ICGC	LATPGNT	DEG_SCF_FBW7_1	732:738	Mutation rewiring degron network	0.1389
p.A745S	DO38201	STAD	ICGC	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.0556
p.P770S	TCGA-LG-A6GG	LIHC	TCGA	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.0833
p.P770S	DO49699	LIHC	ICGC	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.0833
p.L752P	TCGA-WS-AB45	COAD	TCGA	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.25
p.L752P	DO51734	COAD	ICGC	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.25
p.S588Y	DO48991	CESC	ICGC	PSTTT	DEG_SPOP_SBC_1	584:588	Mutation altering degron motif	0.712
p.R768Q	DO222842	COCA	ICGC	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.1389
p.M1023I	DO50348	ESAD	ICGC	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation rewiring degron network	0.3056
p.A379V	DO228971	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.1944
p.T724K	DO229028	LICA	ICGC	LATPGNT	DEG_SCF_FBW7_1	732:738	Mutation rewiring degron network	0.1111
p.T586K	DO229025	LICA	ICGC	PSTTT	DEG_SPOP_SBC_1	584:588	Mutation altering degron motif	0.7306
p.T586K	DO229009	LICA	ICGC	PSTTT	DEG_SPOP_SBC_1	584:588	Mutation altering degron motif	0.7306
p.P584T	DO229031	LICA	ICGC	PSTTT	DEG_SPOP_SBC_1	584:588	Mutation altering degron motif	0.7031
p.A574E	DO229036	LICA	ICGC	PSTTT	DEG_SPOP_SBC_1	584:588	Mutation rewiring degron network	0.0556
p.H728Q	DO229041	LICA	ICGC	LATPGNT	DEG_SCF_FBW7_1	732:738	Mutation rewiring degron network	0.2222
p.L723I	DO229008	LICA	ICGC	LATPGNT	DEG_SCF_FBW7_1	732:738	Mutation rewiring degron network	0.0833
p.C1029R	DO23308	LINC	ICGC	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation rewiring degron network	0.1389
p.V1010I	DO38380	STAD	ICGC	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation rewiring degron network	0.1111
p.A750T	SIDM01307	Colorectal Carcinoma	GDSC	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.1944
p.A750T	SIDM00781	Colorectal Carcinoma	GDSC	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.1944
p.A750T	SIDM00780	Colorectal Carcinoma	GDSC	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.1944
p.A750T	SNU-C2B	large intestine	COSMIC	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.1944
p.R1019C	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation altering degron motif	0.8301
p.R1019C	SIDM00875	Breast Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation altering degron motif	0.8301
p.R1019C	SIDM01133	Other Solid Cancers	GDSC	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation altering degron motif	0.8301
p.R1019C	SIDM00673	Breast Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation altering degron motif	0.8301
p.R1019C	SIDM01318	Hepatocellular Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation altering degron motif	0.8301
p.S1022L	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation altering degron motif	0.7667
p.S1022L	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation altering degron motif	0.7667
p.K748N	SIDM00571	Pancreatic Carcinoma	GDSC	LATPGNT	DEG_SCF_FBW7_1	732:738	Mutation rewiring degron network	0.0556
p.K748N	SIDM00571	Pancreatic Carcinoma	GDSC	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.1389
p.K748N	KP-3	pancreas	COSMIC	LATPGNT	DEG_SCF_FBW7_1	732:738	Mutation rewiring degron network	0.0556
p.K748N	KP-3	pancreas	COSMIC	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.1389
p.G724S	SIDM00839	Colorectal Carcinoma	GDSC	LATPGNT	DEG_SCF_FBW7_1	732:738	Mutation rewiring degron network	0.1111
p.G724S	LoVo	large intestine	COSMIC	LATPGNT	DEG_SCF_FBW7_1	732:738	Mutation rewiring degron network	0.1111
p.T1021R	ACH-000819	Brain Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation altering degron motif	0.7876
p.T1021R	LN-18	central nervous system	COSMIC	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation altering degron motif	0.7876
p.P756R	ACH-000852	Lung Cancer	CCLE	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation altering degron motif	0.6401
p.P756R	NCI-H1435	lung	COSMIC	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation altering degron motif	0.6401
p.A733T	ACH-000967	Colon/Colorectal Cancer	CCLE	LATPGNT	DEG_SCF_FBW7_1	732:738	Mutation altering degron motif	0.6028
p.A733T	ACH-001199	Colon/Colorectal Cancer	CCLE	LATPGNT	DEG_SCF_FBW7_1	732:738	Mutation altering degron motif	0.6028
p.A733T	SNU-C2B	large intestine	COSMIC	LATPGNT	DEG_SCF_FBW7_1	732:738	Mutation altering degron motif	0.6028
p.D1027V	ACH-000970	Colon/Colorectal Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation rewiring degron network	0.1944
p.D1027V	SNU-C5	large intestine	COSMIC	PLSTS	DEG_SPOP_SBC_1	1018:1022	Mutation rewiring degron network	0.1944
p.L764V	ACH-001715	Bone Cancer	CCLE	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.25
p.L764V	CAL-72	bone	COSMIC	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation rewiring degron network	0.25
p.T757P	ACH-002237	Bile Duct Cancer	CCLE	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation altering degron motif	0.8142
p.L755P	MDA-MB-415	breast	COSMIC	LPTPEST	DEG_SCF_FBW7_1	755:761	Mutation altering degron motif	0.6471
p.S384L	GR-ST	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0556
p.K731N	KP-3	pancreas	COSMIC	LATPGNT	DEG_SCF_FBW7_1	732:738	Mutation rewiring degron network	0.3056
p.Q378R	SW1573	lung	COSMIC	AGSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.2222
p.V362F	Jurkat	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEMA6A

UniProt ID: Q9H2E6

Entrez ID: 57556

Protein name: Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEMA6A in