DegronMD

Uniprot ID: Q9H2E6

Source protein: Semaphorin-6A

Source gene: SEMA6A

Class: DEG_SCF_FBW7_1

Location: 732:738

E3 ligase: FBXW7

DEGRON score: 0.7311

ASA_SCORE: 63.7143

COIL: 0.8063

CONS_SCORE: 0.3375

DSS_SCORE: 0.4752

HELIX: 0.1047

FCONS_SCORE: 0.8803

RIG_SCORE: 0.6725

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M727I	TCGA-17-Z062	LUAD	TCGA	LATPGNT	DEG_SCF_FBW7_1	0.1944
p.K740R	TCGA-AP-A059	UCEC	TCGA	LATPGNT	DEG_SCF_FBW7_1	0.2778
p.K740R	DO41361	UCEC	ICGC	LATPGNT	DEG_SCF_FBW7_1	0.2778
p.A745S	TCGA-F1-6874	STAD	TCGA	LATPGNT	DEG_SCF_FBW7_1	0.1389
p.A745S	TCGA-Q1-A5R2	CESC	TCGA	LATPGNT	DEG_SCF_FBW7_1	0.1389
p.A745S	DO49003	CESC	ICGC	LATPGNT	DEG_SCF_FBW7_1	0.1389
p.A745S	DO38201	STAD	ICGC	LATPGNT	DEG_SCF_FBW7_1	0.1389
p.T724K	DO229028	LICA	ICGC	LATPGNT	DEG_SCF_FBW7_1	0.1111
p.H728Q	DO229041	LICA	ICGC	LATPGNT	DEG_SCF_FBW7_1	0.2222
p.L723I	DO229008	LICA	ICGC	LATPGNT	DEG_SCF_FBW7_1	0.0833
p.K748N	SIDM00571	Pancreatic Carcinoma	GDSC	LATPGNT	DEG_SCF_FBW7_1	0.0556
p.K748N	KP-3	pancreas	COSMIC	LATPGNT	DEG_SCF_FBW7_1	0.0556
p.G724S	SIDM00839	Colorectal Carcinoma	GDSC	LATPGNT	DEG_SCF_FBW7_1	0.1111
p.G724S	LoVo	large_intestine	COSMIC	LATPGNT	DEG_SCF_FBW7_1	0.1111
p.A733T	ACH-000967	Colon/Colorectal Cancer	CCLE	LATPGNT	DEG_SCF_FBW7_1	0.6028
p.A733T	ACH-001199	Colon/Colorectal Cancer	CCLE	LATPGNT	DEG_SCF_FBW7_1	0.6028
p.A733T	SNU-C2B	large_intestine	COSMIC	LATPGNT	DEG_SCF_FBW7_1	0.6028
p.K731N	KP-3	pancreas	COSMIC	LATPGNT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2E6	Semaphorin-6A	DEG_SCF_FBW7_1	732:738	LATPGNT	FBXW7	0.7311	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons