DegronMD

Uniprot ID: Q9H2E6

Source protein: Semaphorin-6A

Source gene: SEMA6A

Class: DEG_SPOP_SBC_1

Location: 1018:1022

E3 ligase: SPOP

DEGRON score: 0.9889

ASA_SCORE: 76.24

COIL: 0.9376

CONS_SCORE: 0.3753

DSS_SCORE: 0.6407

HELIX: 0.0286

FCONS_SCORE: 0.9345

RIG_SCORE: 0.6535

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1019C	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.8301
p.R1019C	SIDM00875	Breast Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.8301
p.R1019C	SIDM01133	Other Solid Cancers	GDSC	PLSTS	DEG_SPOP_SBC_1	0.8301
p.R1019C	SIDM00673	Breast Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.8301
p.R1019C	SIDM01318	Hepatocellular Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.8301
p.T1021R	ACH-000819	Brain Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	0.7876
p.T1021R	LN-18	central_nervous_system	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.7876
p.S1022L	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7667
p.S1022L	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.7667
p.S1022Y	TCGA-AP-A1DK	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	0.712
p.S1022Y	DO42033	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.712
p.M1023I	DO50348	ESAD	ICGC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.K1024E	TCGA-DI-A1BU	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	0.2778
p.K1024E	DO42023	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.2778
p.D1027V	ACH-000970	Colon/Colorectal Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	0.1944
p.D1027V	SNU-C5	large_intestine	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.1944
p.P1012S	TCGA-4T-AA8H	COAD	TCGA	PLSTS	DEG_SPOP_SBC_1	0.1667
p.P1012S	DO51724	COAD	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1667
p.A1028V	TCGA-A5-A1OF	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	0.1667
p.A1028V	DO221545	PACA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1667
p.A1028V	DO42568	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1667
p.C1029R	DO23308	LINC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1389
p.V1010I	DO38380	STAD	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1111

Showing 1 to 23 of 23 entries

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Drug responses associated with SEMA6A mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PLSTS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	336:340	PLSTS	SPOP	0.9301	More...
Q99490	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	1046:1050	PLSTS	SPOP	0.6945	More...
Q6ZU67	BEN domain-containing protein 4	DEG_SPOP_SBC_1	281:285	PLSTS	SPOP	0.8233	More...
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	553:557	PLSTS	SPOP	0.8233	More...
P28562	Dual specificity protein phosphatase 1	DEG_SPOP_SBC_1	148:152	PLSTS	SPOP	0.9304	More...
Q5XPI4	E3 ubiquitin-protein ligase RNF123	DEG_SPOP_SBC_1	698:702	PLSTS	SPOP	0.9944	More...
Q5THR3	EF-hand calcium-binding domain-containing protein 6	DEG_SPOP_SBC_1	119:123	PLSTS	SPOP	0.6545	More...
O00167	Eyes absent homolog 2	DEG_SPOP_SBC_1	196:200	PLSTS	SPOP	0.8269	More...
Q8TEQ6	Gem-associated protein 5	DEG_SPOP_SBC_1	850:854	PLSTS	SPOP	0.9922	More...
Q9H706	GRB2-associated and regulator of MAPK protein 1	DEG_SPOP_SBC_1	542:546	PLSTS	SPOP	0.9196	More...
Q9UBP5	Hairy/enhancer-of-split related with YRPW motif protein 2	DEG_SPOP_SBC_1	252:256	PLSTS	SPOP	0.7183	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	2661:2665	PLSTS	SPOP	0.8392	More...
Q53TQ3	INO80 complex subunit D	DEG_SPOP_SBC_1	214:218	PLSTS	SPOP	0.9858	More...
Q96Q89	Kinesin-like protein KIF20B	DEG_SPOP_SBC_1	1584:1588	PLSTS	SPOP	0.9863	More...
Q86UK5	Limbin	DEG_SPOP_SBC_1	112:116	PLSTS	SPOP	0.7993	More...
Q8IY33	MICAL-like protein 2	DEG_SPOP_SBC_1	519:523	PLSTS	SPOP	0.9828	More...
Q99570	Phosphoinositide 3-kinase regulatory subunit 4	DEG_SPOP_SBC_1	901:905	PLSTS	SPOP	0.9634	More...
Q96HE9	Proline-rich protein 11	DEG_SPOP_SBC_1	350:354	PLSTS	SPOP	0.9951	More...
Q9H2E6	Semaphorin-6A	DEG_SPOP_SBC_1	1018:1022	PLSTS	SPOP	0.9889	More...
Q6ZUB1	Spermatogenesis-associated protein 31E1	DEG_SPOP_SBC_1	1149:1153	PLSTS	SPOP	0.9944	More...
Q8IY92	Structure-specific endonuclease subunit SLX4	DEG_SPOP_SBC_1	1448:1452	PLSTS	SPOP	0.9903	More...
Q86Y82	Syntaxin-12	DEG_SPOP_SBC_1	90:94	PLSTS	SPOP	0.702	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	1075:1079	PLSTS	SPOP	0.9851	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	345:349	PLSTS	SPOP	0.979	More...
Q70CQ3	Ubiquitin carboxyl-terminal hydrolase 30	DEG_SPOP_SBC_1	466:470	PLSTS	SPOP	0.5113	More...

Showing 1 to 25 of 26 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLSTS

Degron related mutations and impact score

Drug responses associated with SEMA6A mutations

All proteins holding degron of PLSTS