DegronMD - Q5THR3(EFCAB6)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1306L	TCGA-32-2632	GBM	TCGA	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.1111
p.P1306L	TCGA-32-2632	GBM	TCGA	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1389
p.S719C	TCGA-85-7699	LUSC	TCGA	PPTPSKS	DEG_SCF_FBW7_1	713:719	Mutation altering degron motif	0.7541
p.P706S	TCGA-A5-A0G1	UCEC	TCGA	PPTPSKS	DEG_SCF_FBW7_1	713:719	Mutation rewiring degron network	0.1389
p.A1296S	TCGA-A5-A0G2	UCEC	TCGA	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation altering degron motif	0.6477
p.A1296S	TCGA-A5-A0G2	UCEC	TCGA	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation altering degron motif	0.6477
p.A728T	TCGA-A5-A0G2	UCEC	TCGA	PPTPSKS	DEG_SCF_FBW7_1	713:719	Mutation rewiring degron network	0.0833
p.Q1289H	TCGA-EE-A20F	SKCM	TCGA	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.25
p.Q1289H	TCGA-EE-A20F	SKCM	TCGA	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1667
p.S723I	TCGA-EK-A2PI	CESC	TCGA	PPTPSKS	DEG_SCF_FBW7_1	713:719	Mutation rewiring degron network	0.2222
p.S1288L	TCGA-EY-A1GI	UCEC	TCGA	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.2222
p.S1288L	TCGA-EY-A1GI	UCEC	TCGA	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1389
p.S1288L	SIDM00469	Pancreatic Carcinoma	GDSC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.2222
p.S1288L	SIDM00469	Pancreatic Carcinoma	GDSC	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1389
p.S1288L	ACH-000320	Pancreatic Cancer	CCLE	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.2222
p.S1288L	ACH-000320	Pancreatic Cancer	CCLE	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1389
p.S1288L	ACH-002066	Sarcoma	CCLE	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.2222
p.S1288L	ACH-002066	Sarcoma	CCLE	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1389
p.S1288L	PSN1	pancreas	COSMIC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.2222
p.S1288L	PSN1	pancreas	COSMIC	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1389
p.P1292L	TCGA-FW-A3R5	SKCM	TCGA	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation altering degron motif	0.6471
p.V721M	TCGA-G4-6309	COAD	TCGA	PPTPSKS	DEG_SCF_FBW7_1	713:719	Mutation rewiring degron network	0.2778
p.P127L	TCGA-OR-A5KB	ACC	TCGA	PLSTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.2222
p.L129F	TCGA-WE-AAA0	SKCM	TCGA	PLSTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1667
p.L129F	DO51294	SKCM	ICGC	PLSTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1667
p.D728H	DO51863	BLCA	ICGC	PPTPSKS	DEG_SCF_FBW7_1	713:719	Mutation rewiring degron network	0.0833
p.V114M	DO218428	BRCA	ICGC	PLSTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1944
p.L117F	DO225072	BRCA	ICGC	PLSTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.2778
p.L117F	DO227701	BRCA	ICGC	PLSTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.2778
p.R1288Q	DO51214	BRCA	ICGC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.2222
p.R1288Q	DO51214	BRCA	ICGC	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1389
p.R1288Q	DO222427	BTCA	ICGC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.2222
p.R1288Q	DO222427	BTCA	ICGC	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1389
p.R1289C	DO8842	COAD	ICGC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.25
p.R1289C	DO8842	COAD	ICGC	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1667
p.V1304I	DO9964	COAD	ICGC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.1667
p.V1304I	DO9964	COAD	ICGC	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1944
p.V1304I	DO9530	COAD	ICGC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.1667
p.V1304I	DO9530	COAD	ICGC	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1944
p.Y1294C	DO52438	COCA	ICGC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation altering degron motif	0.7087
p.E706G	DO14403	HNSC	ICGC	PPTPSKS	DEG_SCF_FBW7_1	713:719	Mutation rewiring degron network	0.1389
p.A116D	DO229015	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.25
p.D113E	DO229026	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1667
p.S1293R	DO229041	LICA	ICGC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation altering degron motif	0.7427
p.R717C	DO45382	LUAD	ICGC	PPTPSKS	DEG_SCF_FBW7_1	713:719	Mutation altering degron motif	0.8301
p.R1289S	DO26553	LUSC	ICGC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.25
p.R1289S	DO26553	LUSC	ICGC	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1667
p.L132F	DO28923	OV	ICGC	PLSTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.0833
p.N111K	DO228016	SKCA	ICGC	PLSTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1111
p.G711S	DO218872	SKCA	ICGC	PPTPSKS	DEG_SCF_FBW7_1	713:719	Mutation rewiring degron network	0.2778
p.D1306N	DO37881	SKCM	ICGC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.1111
p.D1306N	DO37881	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1389
p.S112F	DO37442	SKCM	ICGC	PLSTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1389
p.S112F	DO37966	SKCM	ICGC	PLSTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1389
p.R718Q	DO50299	SKCM	ICGC	PPTPSKS	DEG_SCF_FBW7_1	713:719	Mutation altering degron motif	0.7329
p.R1289H	DO47469	SKCM	ICGC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.25
p.R1289H	DO47469	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1667
p.R1289H	DO38551	STAD	ICGC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.25
p.R1289H	DO38551	STAD	ICGC	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1667
p.R1289H	DB	haematopoietic and lymphoid tissue	COSMIC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.25
p.R1289H	DB	haematopoietic and lymphoid tissue	COSMIC	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1667
p.G726D	DO51254	SKCM	ICGC	PPTPSKS	DEG_SCF_FBW7_1	713:719	Mutation rewiring degron network	0.1389
p.L131H	DO229221	THCA	ICGC	PLSTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1111
p.H1282R	DO41536	UCEC	ICGC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.0556
p.D728G	DO42568	UCEC	ICGC	PPTPSKS	DEG_SCF_FBW7_1	713:719	Mutation rewiring degron network	0.0833
p.D728G	Mo-T	haematopoietic and lymphoid tissue	COSMIC	PPTPSKS	DEG_SCF_FBW7_1	713:719	Mutation rewiring degron network	0.0833
p.A1305T	DO41235	UCEC	ICGC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.1389
p.A1305T	DO41235	UCEC	ICGC	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1667
p.A1296V	SIDM01617	Endometrial Carcinoma	GDSC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation altering degron motif	0.5825
p.A1296V	SIDM01617	Endometrial Carcinoma	GDSC	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation altering degron motif	0.5825
p.A1296V	ACH-000994	Endometrial/Uterine Cancer	CCLE	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation altering degron motif	0.5825
p.A1296V	ACH-000994	Endometrial/Uterine Cancer	CCLE	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation altering degron motif	0.5825
p.P1284L	ACH-001408	Bladder Cancer	CCLE	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.1111
p.D728E	SNU-1040	large intestine	COSMIC	PPTPSKS	DEG_SCF_FBW7_1	713:719	Mutation rewiring degron network	0.0833
p.I720M	NCI-H1836	lung	COSMIC	PPTPSKS	DEG_SCF_FBW7_1	713:719	Mutation rewiring degron network	0.3056
p.V122I	JEG-3	placenta	COSMIC	PLSTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.7076
p.R1288W	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.2222
p.R1288W	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1389
p.R1288W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.2222
p.R1288W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.1389
p.S111L	SW900	lung	COSMIC	PLSTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1111
p.G713D	EW-1	bone	COSMIC	PPTPSKS	DEG_SCF_FBW7_1	713:719	Mutation altering degron motif	0.7198
p.K129N	HT-115	large intestine	COSMIC	PLSTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1667
p.R1285K	COLO-792	skin	COSMIC	PCTPAST	DEG_SCF_FBW7_1	1292:1298	Mutation rewiring degron network	0.1389
p.R1285K	COLO-792	skin	COSMIC	PASTT	DEG_SPOP_SBC_1	1295:1299	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EFCAB6

UniProt ID: Q5THR3

Entrez ID: 64800

Protein name: EF-hand calcium-binding domain-containing protein 6 (CAP-binding protein complex-interacting protein 1) (DJ-1-binding protein) (DJBP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EFCAB6 in