DegronMD

Uniprot ID: Q5THR3

Source protein: EF-hand calcium-binding domain-containing protein 6

Source gene: EFCAB6

Class: DEG_SPOP_SBC_1

Location: 1295:1299

E3 ligase: SPOP

DEGRON score: 0.9774

ASA_SCORE: 75.92

COIL: 0.9038

CONS_SCORE: 0.2757

DSS_SCORE: 0.6597

HELIX: 0.0306

FCONS_SCORE: 0.8667

RIG_SCORE: 0.6252

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1306L	TCGA-32-2632	GBM	TCGA	PASTT	DEG_SPOP_SBC_1	0.1389
p.A1296S	TCGA-A5-A0G2	UCEC	TCGA	PASTT	DEG_SPOP_SBC_1	0.6477
p.Q1289H	TCGA-EE-A20F	SKCM	TCGA	PASTT	DEG_SPOP_SBC_1	0.1667
p.S1288L	TCGA-EY-A1GI	UCEC	TCGA	PASTT	DEG_SPOP_SBC_1	0.1389
p.S1288L	SIDM00469	Pancreatic Carcinoma	GDSC	PASTT	DEG_SPOP_SBC_1	0.1389
p.S1288L	ACH-000320	Pancreatic Cancer	CCLE	PASTT	DEG_SPOP_SBC_1	0.1389
p.S1288L	ACH-002066	Sarcoma	CCLE	PASTT	DEG_SPOP_SBC_1	0.1389
p.S1288L	PSN1	pancreas	COSMIC	PASTT	DEG_SPOP_SBC_1	0.1389
p.R1288Q	DO51214	BRCA	ICGC	PASTT	DEG_SPOP_SBC_1	0.1389
p.R1288Q	DO222427	BTCA	ICGC	PASTT	DEG_SPOP_SBC_1	0.1389
p.R1289C	DO8842	COAD	ICGC	PASTT	DEG_SPOP_SBC_1	0.1667
p.V1304I	DO9964	COAD	ICGC	PASTT	DEG_SPOP_SBC_1	0.1944
p.V1304I	DO9530	COAD	ICGC	PASTT	DEG_SPOP_SBC_1	0.1944
p.R1289S	DO26553	LUSC	ICGC	PASTT	DEG_SPOP_SBC_1	0.1667
p.D1306N	DO37881	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	0.1389
p.R1289H	DO47469	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	0.1667
p.R1289H	DO38551	STAD	ICGC	PASTT	DEG_SPOP_SBC_1	0.1667
p.R1289H	DB	haematopoietic_and_lymphoid_tissue	COSMIC	PASTT	DEG_SPOP_SBC_1	0.1667
p.A1305T	DO41235	UCEC	ICGC	PASTT	DEG_SPOP_SBC_1	0.1667
p.A1296V	SIDM01617	Endometrial Carcinoma	GDSC	PASTT	DEG_SPOP_SBC_1	0.5825
p.A1296V	ACH-000994	Endometrial/Uterine Cancer	CCLE	PASTT	DEG_SPOP_SBC_1	0.5825
p.R1288W	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PASTT	DEG_SPOP_SBC_1	0.1389
p.R1288W	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PASTT	DEG_SPOP_SBC_1	0.1389
p.R1285K	COLO-792	skin	COSMIC	PASTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	983:987	PASTT	SPOP	0.9313	More...
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	988:992	PASTT	SPOP	0.889	More...
P11161	E3 SUMO-protein ligase EGR2	DEG_SPOP_SBC_1	127:131	PASTT	SPOP	0.9571	More...
P20810	Calpastatin	DEG_SPOP_SBC_1	547:551	PASTT	SPOP	0.9976	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	93:97	PASTT	SPOP	0.9667	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2297:2301	PASTT	SPOP	0.6997	More...
P98171	Rho GTPase-activating protein 4	DEG_SPOP_SBC_1	894:898	PASTT	SPOP	0.9571	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1511:1515	PASTT	SPOP	0.6572	More...
Q08999	Retinoblastoma-like protein 2	DEG_SPOP_SBC_1	674:678	PASTT	SPOP	0.9981	More...
Q5THR3	EF-hand calcium-binding domain-containing protein 6	DEG_SPOP_SBC_1	1295:1299	PASTT	SPOP	0.9774	More...
Q6BAA4	Fc receptor-like B	DEG_SPOP_SBC_1	294:298	PASTT	SPOP	0.9844	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	358:362	PASTT	SPOP	0.974	More...
Q99607	ETS-related transcription factor Elf-4	DEG_SPOP_SBC_1	433:437	PASTT	SPOP	0.7975	More...
Q9BR76	Coronin-1B	DEG_SPOP_SBC_1	429:433	PASTT	SPOP	0.9688	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1644:1648	PASTT	SPOP	0.9635	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4925:4929	PASTT	SPOP	0.9738	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4981:4985	PASTT	SPOP	0.7062	More...
Q9Y692	Glucocorticoid modulatory element-binding protein 1	DEG_SPOP_SBC_1	385:389	PASTT	SPOP	0.947	More...
A6NMD0	Interferon-induced transmembrane protein 10	DEG_SPOP_SBC_1	42:46	PASTT	SPOP	0.9896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PASTT

Degron related mutations and impact score

Drug responses associated with EFCAB6 mutations

All proteins holding degron of PASTT