DegronMD

Uniprot ID: Q6BAA4

Source protein: Fc receptor-like B

Source gene: FCRLB

Class: DEG_SPOP_SBC_1

Location: 294:298

E3 ligase: SPOP

DEGRON score: 0.9844

ASA_SCORE: 64.66

COIL: 0.745

CONS_SCORE: 0.8239

DSS_SCORE: 0.5529

HELIX: 0.0354

FCONS_SCORE: 1.1877

RIG_SCORE: 0.6219

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P291L	TCGA-55-8097	LUAD	TCGA	PASTT	DEG_SPOP_SBC_1	0.25
p.P291L	DO25699	LUAD	ICGC	PASTT	DEG_SPOP_SBC_1	0.25
p.S296C	TCGA-CN-5358	HNSC	TCGA	PASTT	DEG_SPOP_SBC_1	0.7541
p.S296C	DO14878	HNSC	ICGC	PASTT	DEG_SPOP_SBC_1	0.7541
p.P302T	TCGA-CV-5976	HNSC	TCGA	PASTT	DEG_SPOP_SBC_1	0.2222
p.P302T	DO15751	HNSC	ICGC	PASTT	DEG_SPOP_SBC_1	0.2222
p.P291T	TCGA-Q1-A5R2	CESC	TCGA	PASTT	DEG_SPOP_SBC_1	0.25
p.P291T	DO49003	CESC	ICGC	PASTT	DEG_SPOP_SBC_1	0.25
p.A301P	DO48442	BLCA	ICGC	PASTT	DEG_SPOP_SBC_1	0.25
p.A301P	DO230334	COCA	ICGC	PASTT	DEG_SPOP_SBC_1	0.25
p.A301P	DO229010	COCA	ICGC	PASTT	DEG_SPOP_SBC_1	0.25
p.A301P	DO229013	COCA	ICGC	PASTT	DEG_SPOP_SBC_1	0.25
p.A301P	DO229016	COCA	ICGC	PASTT	DEG_SPOP_SBC_1	0.25
p.A301P	DO229003	COCA	ICGC	PASTT	DEG_SPOP_SBC_1	0.25
p.A301P	DO229005	COCA	ICGC	PASTT	DEG_SPOP_SBC_1	0.25
p.A301P	DO229480	LAML	ICGC	PASTT	DEG_SPOP_SBC_1	0.25
p.A301P	DO231031	LUSC	ICGC	PASTT	DEG_SPOP_SBC_1	0.25
p.R294Q	DO8842	COAD	ICGC	PASTT	DEG_SPOP_SBC_1	0.7329
p.R301H	DO233259	GACA	ICGC	PASTT	DEG_SPOP_SBC_1	0.25
p.R301L	DO229015	LICA	ICGC	PASTT	DEG_SPOP_SBC_1	0.25
p.P302S	DO230961	LUSC	ICGC	PASTT	DEG_SPOP_SBC_1	0.2222
p.P302S	DO224594	LUSC	ICGC	PASTT	DEG_SPOP_SBC_1	0.2222
p.P291H	DO233298	NACA	ICGC	PASTT	DEG_SPOP_SBC_1	0.25
p.P297Q	DO37651	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	0.7035
p.R308Q	DO47981	STAD	ICGC	PASTT	DEG_SPOP_SBC_1	0.0556
p.G287W	DO229195	THCA	ICGC	PASTT	DEG_SPOP_SBC_1	0.1389
p.C284Y	DO41584	UCEC	ICGC	PASTT	DEG_SPOP_SBC_1	0.0556
p.T285I	LU-165	lung	COSMIC	PASTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	983:987	PASTT	SPOP	0.9313	More...
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	988:992	PASTT	SPOP	0.889	More...
P11161	E3 SUMO-protein ligase EGR2	DEG_SPOP_SBC_1	127:131	PASTT	SPOP	0.9571	More...
P20810	Calpastatin	DEG_SPOP_SBC_1	547:551	PASTT	SPOP	0.9976	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	93:97	PASTT	SPOP	0.9667	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2297:2301	PASTT	SPOP	0.6997	More...
P98171	Rho GTPase-activating protein 4	DEG_SPOP_SBC_1	894:898	PASTT	SPOP	0.9571	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1511:1515	PASTT	SPOP	0.6572	More...
Q08999	Retinoblastoma-like protein 2	DEG_SPOP_SBC_1	674:678	PASTT	SPOP	0.9981	More...
Q5THR3	EF-hand calcium-binding domain-containing protein 6	DEG_SPOP_SBC_1	1295:1299	PASTT	SPOP	0.9774	More...
Q6BAA4	Fc receptor-like B	DEG_SPOP_SBC_1	294:298	PASTT	SPOP	0.9844	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	358:362	PASTT	SPOP	0.974	More...
Q99607	ETS-related transcription factor Elf-4	DEG_SPOP_SBC_1	433:437	PASTT	SPOP	0.7975	More...
Q9BR76	Coronin-1B	DEG_SPOP_SBC_1	429:433	PASTT	SPOP	0.9688	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1644:1648	PASTT	SPOP	0.9635	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4925:4929	PASTT	SPOP	0.9738	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4981:4985	PASTT	SPOP	0.7062	More...
Q9Y692	Glucocorticoid modulatory element-binding protein 1	DEG_SPOP_SBC_1	385:389	PASTT	SPOP	0.947	More...
A6NMD0	Interferon-induced transmembrane protein 10	DEG_SPOP_SBC_1	42:46	PASTT	SPOP	0.9896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PASTT

Degron related mutations and impact score

Drug responses associated with FCRLB mutations

All proteins holding degron of PASTT