DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 1644:1648

E3 ligase: SPOP

DEGRON score: 0.9635

ASA_SCORE: 81.48

COIL: 0.8544

CONS_SCORE: 0.1716

DSS_SCORE: 0.6754

HELIX: 0.0326

FCONS_SCORE: 0.5978

RIG_SCORE: 0.6591

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1637L	TCGA-2H-A9GN	ESCA	TCGA	PASTT	DEG_SPOP_SBC_1	0.1389
p.P1644L	TCGA-AJ-A2QO	UCEC	TCGA	PASTT	DEG_SPOP_SBC_1	0.7582
p.E1655K	TCGA-EB-A553	SKCM	TCGA	PASTT	DEG_SPOP_SBC_1	0.1389
p.Q1635H	DO44105	BRCA	ICGC	PASTT	DEG_SPOP_SBC_1	0.0833
p.P1640L	DO222364	BTCA	ICGC	PASTT	DEG_SPOP_SBC_1	0.2222
p.Q1635P	DO233854	GACA	ICGC	PASTT	DEG_SPOP_SBC_1	0.0833
p.S1639R	DO231967	LICA	ICGC	PASTT	DEG_SPOP_SBC_1	0.1944
p.P1636L	DO220073	SARC	ICGC	PASTT	DEG_SPOP_SBC_1	0.1111
p.L1656R	DO50288	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	0.1111
p.E1658K	DO47329	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	0.0556
p.P1647L	DO42177	UCEC	ICGC	PASTT	DEG_SPOP_SBC_1	0.7582
p.L1656P	DO42033	UCEC	ICGC	PASTT	DEG_SPOP_SBC_1	0.1111
p.P1637S	ACH-001997	Bile Duct Cancer	CCLE	PASTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	983:987	PASTT	SPOP	0.9313	More...
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	988:992	PASTT	SPOP	0.889	More...
P11161	E3 SUMO-protein ligase EGR2	DEG_SPOP_SBC_1	127:131	PASTT	SPOP	0.9571	More...
P20810	Calpastatin	DEG_SPOP_SBC_1	547:551	PASTT	SPOP	0.9976	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	93:97	PASTT	SPOP	0.9667	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2297:2301	PASTT	SPOP	0.6997	More...
P98171	Rho GTPase-activating protein 4	DEG_SPOP_SBC_1	894:898	PASTT	SPOP	0.9571	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1511:1515	PASTT	SPOP	0.6572	More...
Q08999	Retinoblastoma-like protein 2	DEG_SPOP_SBC_1	674:678	PASTT	SPOP	0.9981	More...
Q5THR3	EF-hand calcium-binding domain-containing protein 6	DEG_SPOP_SBC_1	1295:1299	PASTT	SPOP	0.9774	More...
Q6BAA4	Fc receptor-like B	DEG_SPOP_SBC_1	294:298	PASTT	SPOP	0.9844	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	358:362	PASTT	SPOP	0.974	More...
Q99607	ETS-related transcription factor Elf-4	DEG_SPOP_SBC_1	433:437	PASTT	SPOP	0.7975	More...
Q9BR76	Coronin-1B	DEG_SPOP_SBC_1	429:433	PASTT	SPOP	0.9688	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1644:1648	PASTT	SPOP	0.9635	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4925:4929	PASTT	SPOP	0.9738	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4981:4985	PASTT	SPOP	0.7062	More...
Q9Y692	Glucocorticoid modulatory element-binding protein 1	DEG_SPOP_SBC_1	385:389	PASTT	SPOP	0.947	More...
A6NMD0	Interferon-induced transmembrane protein 10	DEG_SPOP_SBC_1	42:46	PASTT	SPOP	0.9896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PASTT

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of PASTT