DegronMD - Q99607(ELF4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G620C	TCGA-44-8117	LUAD	TCGA	VGLTPVAE	DEG_SCF_FBW7_2	607:614	Mutation rewiring degron network	0.1667
p.G620C	DO24028	LUAD	ICGC	VGLTPVAE	DEG_SCF_FBW7_2	607:614	Mutation rewiring degron network	0.1667
p.S446G	TCGA-49-AARE	LUAD	TCGA	PASTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.0833
p.S446G	DO218922	LUAD	ICGC	PASTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.0833
p.Q445K	TCGA-A4-7583	KIRP	TCGA	PASTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.1111
p.Q445K	DO20870	KIRP	ICGC	PASTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.1111
p.T426M	TCGA-BR-8363	STAD	TCGA	PASTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.1389
p.T426M	DO45043	LINC	ICGC	PASTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.1389
p.T426M	DO47837	STAD	ICGC	PASTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.1389
p.S623Y	TCGA-DD-A3A3	LIHC	TCGA	VGLTPVAE	DEG_SCF_FBW7_2	607:614	Mutation rewiring degron network	0.0833
p.S623Y	DO44878	LIHC	ICGC	VGLTPVAE	DEG_SCF_FBW7_2	607:614	Mutation rewiring degron network	0.0833
p.V443I	TCGA-FI-A2D0	UCEC	TCGA	PASTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.1667
p.V443I	DO43891	UCEC	ICGC	PASTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.1667
p.T440A	DO6390	CLLE	ICGC	PASTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.25
p.P601T	DO229018	LICA	ICGC	VGLTPVAE	DEG_SCF_FBW7_2	607:614	Mutation rewiring degron network	0.1667
p.L615I	DO229032	LICA	ICGC	VGLTPVAE	DEG_SCF_FBW7_2	607:614	Mutation rewiring degron network	0.3056
p.A438S	DO229052	LICA	ICGC	PASTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.3056
p.G431W	DO231072	LUSC	ICGC	PASTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.2778
p.A434D	DO46372	OV	ICGC	PASTT	DEG_SPOP_SBC_1	433:437	Mutation altering degron motif	0.6682
p.V389I	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTTST	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.0556
p.L617F	SIDM00683	Prostate Carcinoma	GDSC	VGLTPVAE	DEG_SCF_FBW7_2	607:614	Mutation rewiring degron network	0.25
p.L617F	ACH-000977	lymph node	CCLE	VGLTPVAE	DEG_SCF_FBW7_2	607:614	Mutation rewiring degron network	0.25
p.L617F	LNCaP-Clone-FGC	prostate	COSMIC	VGLTPVAE	DEG_SCF_FBW7_2	607:614	Mutation rewiring degron network	0.25
p.V382I	SIDM00146	Breast Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.25
p.P368L	SIDM00930	Osteosarcoma	GDSC	PTTST	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1389
p.P368L	CAL-72	bone	COSMIC	PTTST	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1389
p.L370I	SIDM00554	Ovarian Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.L370I	ACH-000524	Ovarian Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.L370I	KURAMOCHI	ovary	COSMIC	PTTST	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.L616F	LNCaP-Clone-FGC	prostate	COSMIC	VGLTPVAE	DEG_SCF_FBW7_2	607:614	Mutation rewiring degron network	0.2778
p.V368I	RT4	urinary tract	COSMIC	PTTST	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1389
p.P447T	NCI-H650	lung	COSMIC	PASTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.0556
p.A369D	KURAMOCHI	ovary	COSMIC	PTTST	DEG_SPOP_SBC_1	375:379	Mutation blocking phosphorylation signal	0.6111

Kaplan plot for ELF4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ELF4

UniProt ID: Q99607

Entrez ID: 2000

Protein name: ETS-related transcription factor Elf-4 (E74-like factor 4) (Myeloid Elf-1-like factor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ELF4 in