DegronMD

Uniprot ID: Q99607

Source protein: ETS-related transcription factor Elf-4

Source gene: ELF4

Class: DEG_SPOP_SBC_1

Location: 375:379

E3 ligase: SPOP

DEGRON score: 0.9537

ASA_SCORE: 64.68

COIL: 0.6828

CONS_SCORE: 0.245

DSS_SCORE: 0.5368

HELIX: 0.0268

FCONS_SCORE: 1.0326

RIG_SCORE: 0.7512

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V389I	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.0556
p.V382I	SIDM00146	Breast Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.25
p.P368L	SIDM00930	Osteosarcoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.1389
p.P368L	CAL-72	bone	COSMIC	PTTST	DEG_SPOP_SBC_1	0.1389
p.L370I	SIDM00554	Ovarian Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.1944
p.L370I	ACH-000524	Ovarian Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	0.1944
p.L370I	KURAMOCHI	ovary	COSMIC	PTTST	DEG_SPOP_SBC_1	0.1944
p.V368I	RT4	urinary_tract	COSMIC	PTTST	DEG_SPOP_SBC_1	0.1389
p.A369D	KURAMOCHI	ovary	COSMIC	PTTST	DEG_SPOP_SBC_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	885:889	PTTST	SPOP	0.9985	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	527:531	PTTST	SPOP	0.9979	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	234:238	PTTST	SPOP	0.8906	More...
P51532	Transcription activator BRG1	DEG_SPOP_SBC_1	1424:1428	PTTST	SPOP	0.6708	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3128:3132	PTTST	SPOP	0.5488	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3811:3815	PTTST	SPOP	0.6407	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3827:3831	PTTST	SPOP	0.5591	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1621:1625	PTTST	SPOP	0.9682	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	170:174	PTTST	SPOP	0.7765	More...
Q8IZA0	Dyslexia-associated protein KIAA0319-like protein	DEG_SPOP_SBC_1	422:426	PTTST	SPOP	0.7723	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	1097:1101	PTTST	SPOP	0.9044	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12198:12202	PTTST	SPOP	0.9133	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	330:334	PTTST	SPOP	0.7052	More...
Q99607	ETS-related transcription factor Elf-4	DEG_SPOP_SBC_1	375:379	PTTST	SPOP	0.9537	More...
Q99715	Collagen alpha-1	DEG_SPOP_SBC_1	825:829	PTTST	SPOP	0.9873	More...
A6NHQ4	Elongin BC and Polycomb repressive complex 2-associated protein	DEG_SPOP_SBC_1	308:312	PTTST	SPOP	0.9826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons