DegronMD - Q14676(MDC1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1433P	TCGA-06-1805	GBM	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1423:1429	Mutation rewiring degron network	0.2222
p.E792D	TCGA-06-5416	GBM	TCGA	IQGRGR	SCF_FBXL2	802:807	Mutation rewiring degron network	0.0556
p.E792D	DO10880	GBM	ICGC	IQGRGR	SCF_FBXL2	802:807	Mutation rewiring degron network	0.0556
p.P1119T	TCGA-17-Z026	LUAD	TCGA	PSTST	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.0556
p.S1458Y	TCGA-39-5031	LUSC	TCGA	PSTST	DEG_SPOP_SBC_1	1457:1461	Mutation altering degron motif	0.712
p.G1189V	TCGA-44-7662	LUAD	TCGA	TPETVVPTA	DEG_COP1_1	1198:1206	Mutation rewiring degron network	0.0833
p.S736I	TCGA-44-7662	LUAD	TCGA	MLTPPQE	DEG_SCF_FBW7_2	723:729	Mutation rewiring degron network	0.1389
p.S736I	DO23597	LUAD	ICGC	MLTPPQE	DEG_SCF_FBW7_2	723:729	Mutation rewiring degron network	0.1389
p.S1194C	TCGA-44-7670	LUAD	TCGA	TPETVVPTA	DEG_COP1_1	1198:1206	Mutation rewiring degron network	0.2222
p.S1194C	DO506	BLCA	ICGC	TPETVVPTA	DEG_COP1_1	1198:1206	Mutation rewiring degron network	0.2222
p.A1534S	TCGA-49-6742	LUAD	TCGA	PSTST	DEG_SPOP_SBC_1	1539:1543	Mutation rewiring degron network	0.1944
p.A1534S	DO25622	LUAD	ICGC	PSTST	DEG_SPOP_SBC_1	1539:1543	Mutation rewiring degron network	0.1944
p.S1430C	TCGA-55-8205	LUAD	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1423:1429	Mutation blocking phosphorylation signal	0.75
p.S1430C	TCGA-55-8205	LUAD	TCGA	PSTST	DEG_SPOP_SBC_1	1416:1420	Mutation blocking phosphorylation signal	0.5
p.G806W	TCGA-64-5779	LUAD	TCGA	IQGRGR	SCF_FBXL2	802:807	Mutation altering degron motif	0.7825
p.G806W	DO24930	LUAD	ICGC	IQGRGR	SCF_FBXL2	802:807	Mutation altering degron motif	0.7825
p.P1416L	TCGA-66-2756	LUSC	TCGA	PSTST	DEG_SPOP_SBC_1	1416:1420	Mutation altering degron motif	0.7582
p.G804V	TCGA-78-7153	LUAD	TCGA	IQGRGR	SCF_FBXL2	802:807	Mutation altering degron motif	0.6421
p.G804V	DO26347	LUAD	ICGC	IQGRGR	SCF_FBXL2	802:807	Mutation altering degron motif	0.6421
p.S1553F	TCGA-85-6561	LUSC	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1546:1552	Mutation rewiring degron network	0.3056
p.S1553F	TCGA-85-6561	LUSC	TCGA	PSTST	DEG_SPOP_SBC_1	1539:1543	Mutation rewiring degron network	0.0556
p.R1313K	TCGA-90-7766	LUSC	TCGA	TPETVVPTA	DEG_COP1_1	1321:1329	Mutation rewiring degron network	0.1111
p.R1313K	TCGA-90-7766	LUSC	TCGA	PVTPKPT	DEG_SCF_FBW7_1	1300:1306	Mutation rewiring degron network	0.1389
p.S1132C	TCGA-A5-A1OH	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	1129:1133	Mutation altering degron motif	0.7541
p.P1344T	TCGA-A6-5665	COAD	TCGA	PVTPKPT	DEG_SCF_FBW7_1	1341:1347	Mutation altering degron motif	0.7031
p.E1415K	TCGA-AG-A002	READ	TCGA	TPETLVPTA	DEG_COP1_1	1403:1411	Mutation rewiring degron network	0.2222
p.E1415K	TCGA-AG-A002	READ	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1423:1429	Mutation rewiring degron network	0.1111
p.E1415K	TCGA-AG-A002	READ	TCGA	PSTST	DEG_SPOP_SBC_1	1416:1420	Mutation rewiring degron network	0.3056
p.T1321I	TCGA-AJ-A3EK	UCEC	TCGA	TPETVVPTA	DEG_COP1_1	1321:1329	Mutation altering degron motif	0.8189
p.P1469S	TCGA-AN-A0AK	BRCA	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1464:1470	Mutation altering degron motif	0.5641
p.R1308W	TCGA-AN-A0AK	BRCA	TCGA	PVTPKPT	DEG_SCF_FBW7_1	1300:1306	Mutation rewiring degron network	0.2778
p.P1590T	TCGA-AP-A051	UCEC	TCGA	LVTPEPT	DEG_SCF_FBW7_1	1587:1593	Mutation altering degron motif	0.7031
p.R1480K	TCGA-AP-A059	UCEC	TCGA	TPETVVPTA	DEG_COP1_1	1485:1493	Mutation rewiring degron network	0.1944
p.R1480K	TCGA-AP-A059	UCEC	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1464:1470	Mutation rewiring degron network	0.0556
p.P1286L	TCGA-AP-A1DV	UCEC	TCGA	TPEPVVPTA	DEG_COP1_1	1280:1288	Mutation altering degron motif	0.7582
p.E1263Q	TCGA-AR-A2LE	BRCA	TCGA	PSTST	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.1389
p.S1318F	TCGA-AX-A06F	UCEC	TCGA	TPETVVPTA	DEG_COP1_1	1321:1329	Mutation blocking phosphorylation signal	0.6944
p.S1389Y	TCGA-AX-A0J0	UCEC	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1382:1388	Mutation rewiring degron network	0.3056
p.S1389Y	TCGA-EO-A22R	UCEC	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1382:1388	Mutation rewiring degron network	0.3056
p.S1353N	TCGA-AX-A1CE	UCEC	TCGA	PVTPKPT	DEG_SCF_FBW7_1	1341:1347	Mutation rewiring degron network	0.1667
p.S1143Y	TCGA-AX-A2HC	UCEC	TCGA	PVTPKPT	DEG_SCF_FBW7_1	1136:1142	Mutation rewiring degron network	0.3056
p.S1143Y	TCGA-AX-A2HC	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.0556
p.T1347I	TCGA-B5-A1MX	UCEC	TCGA	PVTPKPT	DEG_SCF_FBW7_1	1341:1347	Mutation altering degron motif	0.8189
p.R807G	TCGA-BK-A0C9	UCEC	TCGA	IQGRGR	SCF_FBXL2	802:807	Mutation altering degron motif	0.7568
p.R807G	DO41253	UCEC	ICGC	IQGRGR	SCF_FBXL2	802:807	Mutation altering degron motif	0.7568
p.K1232N	TCGA-BR-8680	STAD	TCGA	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation substituting flanking lysine	0.25
p.S1605C	TCGA-BT-A3PH	BLCA	TCGA	TPEPVVPTA	DEG_COP1_1	1608:1616	Mutation blocking phosphorylation signal	0.6944
p.D1462E	TCGA-BW-A5NP	LIHC	TCGA	TPETVVPTA	DEG_COP1_1	1444:1452	Mutation rewiring degron network	0.0556
p.D1462E	TCGA-BW-A5NP	LIHC	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1464:1470	Mutation rewiring degron network	0.2778
p.D1462E	TCGA-BW-A5NP	LIHC	TCGA	PSTST	DEG_SPOP_SBC_1	1457:1461	Mutation rewiring degron network	0.3056
p.L645I	TCGA-CD-A4MG	STAD	TCGA	SRENLTDLV	DEG_APCC_DBOX_1	641:649	Mutation altering degron motif	0.7174
p.L645I	DO48009	STAD	ICGC	SRENLTDLV	DEG_APCC_DBOX_1	641:649	Mutation altering degron motif	0.7174
p.R1390W	TCGA-CM-5348	COAD	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1382:1388	Mutation rewiring degron network	0.2778
p.G1401C	TCGA-CN-6010	HNSC	TCGA	TPETLVPTA	DEG_COP1_1	1403:1411	Mutation rewiring degron network	0.2778
p.S1253Y	TCGA-CN-6992	HNSC	TCGA	PSTST	DEG_SPOP_SBC_1	1252:1256	Mutation altering degron motif	0.6009
p.D1175Y	TCGA-CR-7388	HNSC	TCGA	TPEPVVPTA	DEG_COP1_1	1157:1165	Mutation rewiring degron network	0.0556
p.D1175Y	TCGA-CR-7388	HNSC	TCGA	PSTST	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.3056
p.S1440F	TCGA-CV-A468	HNSC	TCGA	TPETVVPTA	DEG_COP1_1	1444:1452	Mutation blocking phosphorylation signal	0.6667
p.N1397H	TCGA-D1-A16Y	UCEC	TCGA	TPETLVPTA	DEG_COP1_1	1403:1411	Mutation rewiring degron network	0.1667
p.N1397H	TCGA-D1-A16Y	UCEC	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1382:1388	Mutation rewiring degron network	0.0833
p.P1166H	TCGA-D1-A177	UCEC	TCGA	TPEPVVPTA	DEG_COP1_1	1157:1165	Mutation rewiring degron network	0.3056
p.P1166H	TCGA-D1-A177	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.2222
p.P1453L	TCGA-D3-A3MU	SKCM	TCGA	TPETVVPTA	DEG_COP1_1	1444:1452	Mutation rewiring degron network	0.3056
p.P1453L	TCGA-D3-A3MU	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	1457:1461	Mutation rewiring degron network	0.2222
p.R1603W	TCGA-DD-AAE2	LIHC	TCGA	TPEPVVPTA	DEG_COP1_1	1608:1616	Mutation rewiring degron network	0.1944
p.R1603W	TCGA-DD-AAE2	LIHC	TCGA	LVTPEPT	DEG_SCF_FBW7_1	1587:1593	Mutation rewiring degron network	0.0556
p.R1562K	TCGA-DK-A1AD	BLCA	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1546:1552	Mutation rewiring degron network	0.0556
p.R1595W	TCGA-DS-A1OB	CESC	TCGA	LVTPEPT	DEG_SCF_FBW7_1	1587:1593	Mutation rewiring degron network	0.2778
p.R1595W	SIDM00128	Head and Neck Carcinoma	GDSC	LVTPEPT	DEG_SCF_FBW7_1	1587:1593	Mutation rewiring degron network	0.2778
p.R1595W	ACH-002249	Head and Neck Cancer	CCLE	LVTPEPT	DEG_SCF_FBW7_1	1587:1593	Mutation rewiring degron network	0.2778
p.R1595W	JHU-011	upper aerodigestive tract	COSMIC	LVTPEPT	DEG_SCF_FBW7_1	1587:1593	Mutation rewiring degron network	0.2778
p.R1480I	TCGA-DU-6392	LGG	TCGA	TPETVVPTA	DEG_COP1_1	1485:1493	Mutation rewiring degron network	0.1944
p.R1480I	TCGA-DU-6392	LGG	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1464:1470	Mutation rewiring degron network	0.0556
p.E1208K	TCGA-DU-6407	LGG	TCGA	TPETVVPTA	DEG_COP1_1	1198:1206	Mutation rewiring degron network	0.2778
p.E1208K	TCGA-DU-6407	LGG	TCGA	PSTST	DEG_SPOP_SBC_1	1211:1215	Mutation rewiring degron network	0.25
p.P1139S	TCGA-EB-A3XC	SKCM	TCGA	PVTPKPT	DEG_SCF_FBW7_1	1136:1142	Mutation altering degron motif	0.6752
p.T1634I	TCGA-EC-A1QX	UCEC	TCGA	PVTPKLT	DEG_SCF_FBW7_1	1628:1634	Mutation altering degron motif	0.7078
p.P1371S	TCGA-EE-A181	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	1374:1378	Mutation rewiring degron network	0.25
p.P1368S	TCGA-EE-A2GL	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	1374:1378	Mutation rewiring degron network	0.1667
p.G1230E	TCGA-EO-A22U	UCEC	TCGA	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.0833
p.G1435D	TCGA-EO-A3AV	UCEC	TCGA	TPETVVPTA	DEG_COP1_1	1444:1452	Mutation rewiring degron network	0.0833
p.G1435D	TCGA-EO-A3AV	UCEC	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1423:1429	Mutation rewiring degron network	0.1667
p.D1503H	TCGA-EY-A1GU	UCEC	TCGA	TPETVVPTA	DEG_COP1_1	1485:1493	Mutation rewiring degron network	0.0556
p.R1395I	TCGA-F5-6814	READ	TCGA	TPETLVPTA	DEG_COP1_1	1403:1411	Mutation rewiring degron network	0.1111
p.R1395I	TCGA-F5-6814	READ	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1382:1388	Mutation rewiring degron network	0.1389
p.N1397I	TCGA-F7-A61S	HNSC	TCGA	TPETLVPTA	DEG_COP1_1	1403:1411	Mutation rewiring degron network	0.1667
p.N1397I	TCGA-F7-A61S	HNSC	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1382:1388	Mutation rewiring degron network	0.0833
p.P1469H	TCGA-FD-A3N5	BLCA	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1464:1470	Mutation altering degron motif	0.6583
p.A1533T	TCGA-FI-A2D0	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	1539:1543	Mutation rewiring degron network	0.1667
p.A721V	TCGA-FR-A8YC	SKCM	TCGA	MLTPPQE	DEG_SCF_FBW7_2	723:729	Mutation rewiring degron network	0.2778
p.A721V	DO50301	SKCM	ICGC	MLTPPQE	DEG_SCF_FBW7_2	723:729	Mutation rewiring degron network	0.2778
p.P727S	TCGA-FV-A2QR	LIHC	TCGA	MLTPPQE	DEG_SCF_FBW7_2	723:729	Mutation altering degron motif	0.5641
p.P727S	DO22837	LIHC	ICGC	MLTPPQE	DEG_SCF_FBW7_2	723:729	Mutation altering degron motif	0.5641
p.T1459I	TCGA-FW-A3R5	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	1457:1461	Mutation altering degron motif	0.8189
p.P1426H	TCGA-G4-6628	COAD	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1423:1429	Mutation altering degron motif	0.7694
p.S1458C	TCGA-GD-A3OQ	BLCA	TCGA	PSTST	DEG_SPOP_SBC_1	1457:1461	Mutation altering degron motif	0.7541
p.T1328I	TCGA-HU-A4GN	STAD	TCGA	TPETVVPTA	DEG_COP1_1	1321:1329	Mutation altering degron motif	0.8189
p.V1606F	TCGA-KN-8424	KICH	TCGA	TPEPVVPTA	DEG_COP1_1	1608:1616	Mutation rewiring degron network	0.2778
p.T1451A	TCGA-LP-A4AW	CESC	TCGA	TPETVVPTA	DEG_COP1_1	1444:1452	Mutation altering degron motif	0.7139
p.R1231I	TCGA-QS-A5YQ	UCEC	TCGA	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1111
p.R1644M	TCGA-VQ-A8P2	STAD	TCGA	PVTPKLT	DEG_SCF_FBW7_1	1628:1634	Mutation rewiring degron network	0.0556
p.R1308Q	TCGA-VQ-A8P2	STAD	TCGA	PVTPKPT	DEG_SCF_FBW7_1	1300:1306	Mutation rewiring degron network	0.2778
p.R1390Q	TCGA-VQ-A91E	STAD	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1382:1388	Mutation rewiring degron network	0.2778
p.R1390Q	ACH-000897	Thyroid Cancer	CCLE	PVTPEPT	DEG_SCF_FBW7_1	1382:1388	Mutation rewiring degron network	0.2778
p.R1390Q	ACH-000903	Thyroid Cancer	CCLE	PVTPEPT	DEG_SCF_FBW7_1	1382:1388	Mutation rewiring degron network	0.2778
p.R1390Q	ACH-001390	Breast Cancer	CCLE	PVTPEPT	DEG_SCF_FBW7_1	1382:1388	Mutation rewiring degron network	0.2778
p.R1390Q	FTC-133	thyroid	COSMIC	PVTPEPT	DEG_SCF_FBW7_1	1382:1388	Mutation rewiring degron network	0.2778
p.R805K	TCGA-VS-A9UP	CESC	TCGA	IQGRGR	SCF_FBXL2	802:807	Mutation altering degron motif	0.7237
p.R805K	DO219737	CESC	ICGC	IQGRGR	SCF_FBXL2	802:807	Mutation altering degron motif	0.7237
p.P1127L	TCGA-W3-AA1V	SKCM	TCGA	PVTPKPT	DEG_SCF_FBW7_1	1136:1142	Mutation rewiring degron network	0.0833
p.P1127L	TCGA-W3-AA1V	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.2778
p.T1425A	TCGA-WE-A8ZM	SKCM	TCGA	PVTPEPT	DEG_SCF_FBW7_1	1423:1429	Mutation altering degron motif	0.825
p.P639L	TCGA-WS-AB45	COAD	TCGA	SRENLTDLV	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.2778
p.P639L	DO51734	COAD	ICGC	SRENLTDLV	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.2778
p.P639L	DO233634	GACA	ICGC	SRENLTDLV	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.2778
p.S1341C	DO856	BLCA	ICGC	PVTPKPT	DEG_SCF_FBW7_1	1341:1347	Mutation altering degron motif	0.7541
p.R1298K	DO459	BLCA	ICGC	TPEPVVPTA	DEG_COP1_1	1280:1288	Mutation rewiring degron network	0.0556
p.R1298K	DO459	BLCA	ICGC	PVTPKPT	DEG_SCF_FBW7_1	1300:1306	Mutation rewiring degron network	0.2778
p.R1298K	DO459	BLCA	ICGC	PSTST	DEG_SPOP_SBC_1	1293:1297	Mutation rewiring degron network	0.3056
p.P1205H	DO639	BLCA	ICGC	TPETVVPTA	DEG_COP1_1	1198:1206	Mutation altering degron motif	0.7694
p.G1294C	DO225347	BRCA	ICGC	PSTST	DEG_SPOP_SBC_1	1293:1297	Mutation altering degron motif	0.76
p.G1294C	DO230525	LUSC	ICGC	PSTST	DEG_SPOP_SBC_1	1293:1297	Mutation altering degron motif	0.76
p.G1294C	DO230937	LUSC	ICGC	PSTST	DEG_SPOP_SBC_1	1293:1297	Mutation altering degron motif	0.76
p.T1400S	DO228483	BRCA	ICGC	TPETLVPTA	DEG_COP1_1	1403:1411	Mutation blocking phosphorylation signal	0.6944
p.T1400S	DO230659	LAML	ICGC	TPETLVPTA	DEG_COP1_1	1403:1411	Mutation blocking phosphorylation signal	0.6944
p.T1400S	DO231140	LAML	ICGC	TPETLVPTA	DEG_COP1_1	1403:1411	Mutation blocking phosphorylation signal	0.6944
p.P1205S	DO1608	BRCA	ICGC	TPETVVPTA	DEG_COP1_1	1198:1206	Mutation altering degron motif	0.6752
p.V814I	DO3910	BRCA	ICGC	IQGRGR	SCF_FBXL2	802:807	Mutation rewiring degron network	0.1389
p.L1396F	DO2198	BRCA	ICGC	TPETLVPTA	DEG_COP1_1	1403:1411	Mutation substituting flanking lysine	0.25
p.L1396F	DO2198	BRCA	ICGC	PVTPEPT	DEG_SCF_FBW7_1	1382:1388	Mutation substituting flanking lysine	0.2222
p.S1394F	DO49976	CESC	ICGC	TPETLVPTA	DEG_COP1_1	1403:1411	Mutation rewiring degron network	0.0833
p.S1394F	DO49976	CESC	ICGC	PVTPEPT	DEG_SCF_FBW7_1	1382:1388	Mutation rewiring degron network	0.1667
p.R1331W	DO6323	CESC	ICGC	TPETVVPTA	DEG_COP1_1	1321:1329	Mutation rewiring degron network	0.2778
p.R1331W	DO6323	CESC	ICGC	PVTPKPT	DEG_SCF_FBW7_1	1341:1347	Mutation rewiring degron network	0.0556
p.P1162H	DO10132	COAD	ICGC	TPEPVVPTA	DEG_COP1_1	1157:1165	Mutation altering degron motif	0.7694
p.R1257Q	DO7938	COAD	ICGC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.0556
p.R1257Q	DO7938	COAD	ICGC	PSTST	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.3056
p.R1126W	DO9514	COAD	ICGC	PVTPKPT	DEG_SCF_FBW7_1	1136:1142	Mutation rewiring degron network	0.0556
p.R1126W	DO9514	COAD	ICGC	PSTST	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.25
p.R1254K	DO8264	COAD	ICGC	PSTST	DEG_SPOP_SBC_1	1252:1256	Mutation altering degron motif	0.7237
p.C1335G	DO224664	COCA	ICGC	TPETVVPTA	DEG_COP1_1	1321:1329	Mutation rewiring degron network	0.1667
p.C1335G	DO224664	COCA	ICGC	PVTPKPT	DEG_SCF_FBW7_1	1341:1347	Mutation rewiring degron network	0.1667
p.S1244P	DO222590	COCA	ICGC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation altering degron motif	0.6752
p.P1364S	DO233109	GACA	ICGC	PPSTS	DEG_SPOP_SBC_1	1374:1378	Mutation rewiring degron network	0.0556
p.R1134I	DO233754	GACA	ICGC	PVTPKPT	DEG_SCF_FBW7_1	1136:1142	Mutation rewiring degron network	0.2778
p.R1134I	DO233754	GACA	ICGC	PSTST	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.3056
p.E643Q	DO233777	GACA	ICGC	SRENLTDLV	DEG_APCC_DBOX_1	641:649	Mutation altering degron motif	0.5633
p.L655I	DO233942	GACA	ICGC	SRENLTDLV	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.1667
p.T1169P	DO11567	GBM	ICGC	TPEPVVPTA	DEG_COP1_1	1157:1165	Mutation rewiring degron network	0.2222
p.T1169P	DO11567	GBM	ICGC	PSTST	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.3056
p.G1137C	DO14766	HNSC	ICGC	PVTPKPT	DEG_SCF_FBW7_1	1136:1142	Mutation altering degron motif	0.76
p.N1133I	DO44427	HNSC	ICGC	PSTST	DEG_SPOP_SBC_1	1129:1133	Mutation altering degron motif	0.728
p.S1479C	DO14348	HNSC	ICGC	TPETVVPTA	DEG_COP1_1	1485:1493	Mutation rewiring degron network	0.1667
p.S1479C	DO14348	HNSC	ICGC	PVTPEPT	DEG_SCF_FBW7_1	1464:1470	Mutation rewiring degron network	0.0833
p.S1176F	DO52070	HNSC	ICGC	PSTST	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.2778
p.V1342F	DO220468	KICH	ICGC	PVTPKPT	DEG_SCF_FBW7_1	1341:1347	Mutation altering degron motif	0.5957
p.Q1281R	DO229505	LAML	ICGC	TPEPVVPTA	DEG_COP1_1	1280:1288	Mutation altering degron motif	0.7329
p.S1276P	DO229505	LAML	ICGC	TPEPVVPTA	DEG_COP1_1	1280:1288	Mutation blocking phosphorylation signal	0.6667
p.P801L	DO50208	LGG	ICGC	IQGRGR	SCF_FBXL2	802:807	Mutation rewiring degron network	0.3056
p.P1309A	DO22397	LGG	ICGC	PVTPKPT	DEG_SCF_FBW7_1	1300:1306	Mutation rewiring degron network	0.25
p.R1216I	DO22237	LGG	ICGC	TPETVVPTA	DEG_COP1_1	1198:1206	Mutation rewiring degron network	0.0556
p.R1216I	DO22237	LGG	ICGC	PSTST	DEG_SPOP_SBC_1	1211:1215	Mutation rewiring degron network	0.3056
p.E1435A	DO22237	LGG	ICGC	TPETVVPTA	DEG_COP1_1	1444:1452	Mutation rewiring degron network	0.0833
p.E1435A	DO22237	LGG	ICGC	PVTPEPT	DEG_SCF_FBW7_1	1423:1429	Mutation rewiring degron network	0.1667
p.Q1416R	DO22237	LGG	ICGC	PSTST	DEG_SPOP_SBC_1	1416:1420	Mutation altering degron motif	0.7329
p.Q803R	DO50836	LICA	ICGC	IQGRGR	SCF_FBXL2	802:807	Mutation altering degron motif	0.7329
p.P727L	DO50951	LICA	ICGC	MLTPPQE	DEG_SCF_FBW7_2	723:729	Mutation altering degron motif	0.6471
p.R1339W	DO52256	LIHC	ICGC	TPETVVPTA	DEG_COP1_1	1321:1329	Mutation rewiring degron network	0.0556
p.R1339W	DO52256	LIHC	ICGC	PVTPKPT	DEG_SCF_FBW7_1	1341:1347	Mutation rewiring degron network	0.2778
p.D1198E	DO52172	LIHC	ICGC	TPETVVPTA	DEG_COP1_1	1198:1206	Mutation altering degron motif	0.6758
p.I1310V	DO231862	LINC	ICGC	PVTPKPT	DEG_SCF_FBW7_1	1300:1306	Mutation rewiring degron network	0.2222
p.T1366I	DO229177	LMS	ICGC	PPSTS	DEG_SPOP_SBC_1	1374:1378	Mutation rewiring degron network	0.1111
p.Q792E	DO25113	LUAD	ICGC	IQGRGR	SCF_FBXL2	802:807	Mutation rewiring degron network	0.0556
p.S1166C	DO48884	LUAD	ICGC	TPEPVVPTA	DEG_COP1_1	1157:1165	Mutation rewiring degron network	0.3056
p.S1166C	DO48884	LUAD	ICGC	PSTST	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.2222
p.Q1413E	DO51195	LUAD	ICGC	PVTPEPT	DEG_SCF_FBW7_1	1423:1429	Mutation substituting flanking lysine	0.1667
p.Q1413E	DO51195	LUAD	ICGC	PSTST	DEG_SPOP_SBC_1	1416:1420	Mutation substituting flanking lysine	0.3611
p.R1292Q	DO230525	LUSC	ICGC	TPEPVVPTA	DEG_COP1_1	1280:1288	Mutation rewiring degron network	0.2222
p.R1292Q	DO230525	LUSC	ICGC	PVTPKPT	DEG_SCF_FBW7_1	1300:1306	Mutation rewiring degron network	0.1111
p.R1292Q	DO230525	LUSC	ICGC	PSTST	DEG_SPOP_SBC_1	1293:1297	Mutation rewiring degron network	0.3056
p.S1194Y	DO26526	LUSC	ICGC	TPETVVPTA	DEG_COP1_1	1198:1206	Mutation rewiring degron network	0.2222
p.S1289F	DO26518	LUSC	ICGC	TPEPVVPTA	DEG_COP1_1	1280:1288	Mutation rewiring degron network	0.3056
p.S1289F	DO26518	LUSC	ICGC	PSTST	DEG_SPOP_SBC_1	1293:1297	Mutation rewiring degron network	0.2222
p.E1435Q	DO26593	LUSC	ICGC	TPETVVPTA	DEG_COP1_1	1444:1452	Mutation rewiring degron network	0.0833
p.E1435Q	DO26593	LUSC	ICGC	PVTPEPT	DEG_SCF_FBW7_1	1423:1429	Mutation rewiring degron network	0.1667
p.P1152L	DO27128	LUSC	ICGC	TPEPVVPTA	DEG_COP1_1	1157:1165	Mutation rewiring degron network	0.1944
p.P1152L	DO27128	LUSC	ICGC	PVTPKPT	DEG_SCF_FBW7_1	1136:1142	Mutation rewiring degron network	0.0556
p.S1542F	DO228308	MALY	ICGC	PSTST	DEG_SPOP_SBC_1	1539:1543	Mutation altering degron motif	0.7982
p.S1542F	DO222731	MELA	ICGC	PSTST	DEG_SPOP_SBC_1	1539:1543	Mutation altering degron motif	0.7982
p.R1331Q	DO220885	MELA	ICGC	TPETVVPTA	DEG_COP1_1	1321:1329	Mutation rewiring degron network	0.2778
p.R1331Q	DO220885	MELA	ICGC	PVTPKPT	DEG_SCF_FBW7_1	1341:1347	Mutation rewiring degron network	0.0556
p.P1316S	DO222749	MELA	ICGC	TPETVVPTA	DEG_COP1_1	1321:1329	Mutation rewiring degron network	0.1944
p.P1316S	DO222749	MELA	ICGC	PVTPKPT	DEG_SCF_FBW7_1	1300:1306	Mutation rewiring degron network	0.0556
p.A632S	DO50718	ORCA	ICGC	SRENLTDLV	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.0833
p.R1131I	DO36556	READ	ICGC	PSTST	DEG_SPOP_SBC_1	1129:1133	Mutation altering degron motif	0.8102
p.P1541H	DO219934	SARC	ICGC	PSTST	DEG_SPOP_SBC_1	1539:1543	Mutation altering degron motif	0.7694
p.S1382F	DO47268	SKCM	ICGC	PVTPEPT	DEG_SCF_FBW7_1	1382:1388	Mutation altering degron motif	0.7982
p.T1195I	DO37406	SKCM	ICGC	TPETVVPTA	DEG_COP1_1	1198:1206	Mutation rewiring degron network	0.25
p.P1189L	DO47337	SKCM	ICGC	TPETVVPTA	DEG_COP1_1	1198:1206	Mutation rewiring degron network	0.0833
p.P1439S	DO47368	SKCM	ICGC	TPETVVPTA	DEG_COP1_1	1444:1452	Mutation rewiring degron network	0.1944
p.P1439S	DO47368	SKCM	ICGC	PVTPEPT	DEG_SCF_FBW7_1	1423:1429	Mutation rewiring degron network	0.0556
p.T1161A	DO51284	SKCM	ICGC	TPEPVVPTA	DEG_COP1_1	1157:1165	Mutation altering degron motif	0.7139
p.T813I	DO51272	SKCM	ICGC	IQGRGR	SCF_FBXL2	802:807	Mutation rewiring degron network	0.1667
p.R1249Q	DO51783	STAD	ICGC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.2778
p.R1249Q	DO51783	STAD	ICGC	PSTST	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.25
p.R1249Q	DO38232	STAD	ICGC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.2778
p.R1249Q	DO38232	STAD	ICGC	PSTST	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.25
p.R1126Q	DO51784	STAD	ICGC	PVTPKPT	DEG_SCF_FBW7_1	1136:1142	Mutation rewiring degron network	0.0556
p.R1126Q	DO51784	STAD	ICGC	PSTST	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.25
p.R1380M	DO51761	STAD	ICGC	PVTPEPT	DEG_SCF_FBW7_1	1382:1388	Mutation rewiring degron network	0.2778
p.R1380M	DO51761	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	1374:1378	Mutation rewiring degron network	0.2778
p.R815C	DO48032	STAD	ICGC	IQGRGR	SCF_FBXL2	802:807	Mutation rewiring degron network	0.1111
p.V1406I	DO47925	STAD	ICGC	TPETLVPTA	DEG_COP1_1	1403:1411	Mutation altering degron motif	0.7076
p.R1254I	DO43186	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	1252:1256	Mutation altering degron motif	0.8102
p.G1171D	DO52412	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	1170:1174	Mutation altering degron motif	0.7198
p.T1370I	DO42592	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	1374:1378	Mutation rewiring degron network	0.2222
p.S1125Y	DO41133	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.2222
p.S1125Y	DO42713	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.2222
p.N1133H	DO41524	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	1129:1133	Mutation altering degron motif	0.7423
p.D1239H	DO41518	UCEC	ICGC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation altering degron motif	0.7688
p.S1422Y	DO41488	UCEC	ICGC	PVTPEPT	DEG_SCF_FBW7_1	1423:1429	Mutation rewiring degron network	0.3056
p.S1422Y	DO41488	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	1416:1420	Mutation rewiring degron network	0.2778
p.R1216K	DO41361	UCEC	ICGC	TPETVVPTA	DEG_COP1_1	1198:1206	Mutation rewiring degron network	0.0556
p.R1216K	DO41361	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	1211:1215	Mutation rewiring degron network	0.3056
p.P1326T	DO42673	UCEC	ICGC	TPETVVPTA	DEG_COP1_1	1321:1329	Mutation altering degron motif	0.7031
p.T1470M	SIDM01965	Esophageal Carcinoma	GDSC	PVTPEPT	DEG_SCF_FBW7_1	1464:1470	Mutation altering degron motif	0.7423
p.V1301L	SIDM00458	Acute Myeloid Leukemia	GDSC	PVTPKPT	DEG_SCF_FBW7_1	1300:1306	Mutation altering degron motif	0.5654
p.V1301L	SIDM00820	Kidney Carcinoma	GDSC	PVTPKPT	DEG_SCF_FBW7_1	1300:1306	Mutation altering degron motif	0.5654
p.V1301L	SIDM00842	Colorectal Carcinoma	GDSC	PVTPKPT	DEG_SCF_FBW7_1	1300:1306	Mutation altering degron motif	0.5654
p.V1301L	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVTPKPT	DEG_SCF_FBW7_1	1300:1306	Mutation altering degron motif	0.5654
p.V1301L	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	PVTPKPT	DEG_SCF_FBW7_1	1300:1306	Mutation altering degron motif	0.5654
p.V1301L	Farage	haematopoietic and lymphoid tissue	COSMIC	PVTPKPT	DEG_SCF_FBW7_1	1300:1306	Mutation altering degron motif	0.5654
p.V1301L	COLO-320-HSR	large intestine	COSMIC	PVTPKPT	DEG_SCF_FBW7_1	1300:1306	Mutation altering degron motif	0.5654
p.V1301L	RCC-ER	kidney	COSMIC	PVTPKPT	DEG_SCF_FBW7_1	1300:1306	Mutation altering degron motif	0.5654
p.G731D	SIDM01109	Other Sarcomas	GDSC	MLTPPQE	DEG_SCF_FBW7_2	723:729	Mutation rewiring degron network	0.2778
p.G731D	ACH-000145	Sarcoma	CCLE	MLTPPQE	DEG_SCF_FBW7_2	723:729	Mutation rewiring degron network	0.2778
p.G731D	SK-LMS-1	soft tissue	COSMIC	MLTPPQE	DEG_SCF_FBW7_2	723:729	Mutation rewiring degron network	0.2778
p.P1494L	SIDM00712	Non-Cancerous	GDSC	TPETVVPTA	DEG_COP1_1	1485:1493	Mutation rewiring degron network	0.3056
p.P1494L	SIDM00713	Mesothelioma	GDSC	TPETVVPTA	DEG_COP1_1	1485:1493	Mutation rewiring degron network	0.3056
p.L730I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	MLTPPQE	DEG_SCF_FBW7_2	723:729	Mutation rewiring degron network	0.3056
p.L730I	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	MLTPPQE	DEG_SCF_FBW7_2	723:729	Mutation rewiring degron network	0.3056
p.L648M	SIDM00255	Neuroblastoma	GDSC	SRENLTDLV	DEG_APCC_DBOX_1	641:649	Mutation altering degron motif	0.5999
p.L648M	ACH-002282	Neuroblastoma	CCLE	SRENLTDLV	DEG_APCC_DBOX_1	641:649	Mutation altering degron motif	0.5999
p.L648M	NB17	autonomic ganglia	COSMIC	SRENLTDLV	DEG_APCC_DBOX_1	641:649	Mutation altering degron motif	0.5999
p.A1124D	SIDM00142	Endometrial Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.1944
p.A1124D	ACH-000864	Endometrial/Uterine Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.1944
p.A1124D	COLO-684	endometrium	COSMIC	PSTST	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.1944
p.T1205A	SIDM00449	B-Lymphoblastic Leukemia	GDSC	TPETVVPTA	DEG_COP1_1	1198:1206	Mutation altering degron motif	0.7139
p.T1205A	SIDM00685	Glioblastoma	GDSC	TPETVVPTA	DEG_COP1_1	1198:1206	Mutation altering degron motif	0.7139
p.T1205A	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	TPETVVPTA	DEG_COP1_1	1198:1206	Mutation altering degron motif	0.7139
p.P1628L	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PVTPKLT	DEG_SCF_FBW7_1	1628:1634	Mutation altering degron motif	0.6471
p.P1628L	ACH-000823	Esophageal Cancer	CCLE	PVTPKLT	DEG_SCF_FBW7_1	1628:1634	Mutation altering degron motif	0.6471
p.P1628L	KYSE-140	oesophagus	COSMIC	PVTPKLT	DEG_SCF_FBW7_1	1628:1634	Mutation altering degron motif	0.6471
p.P1617H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	TPEPVVPTA	DEG_COP1_1	1608:1616	Mutation rewiring degron network	0.3056
p.P1617H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PTTST	DEG_SPOP_SBC_1	1621:1625	Mutation rewiring degron network	0.2222
p.G1558D	SIDM00151	Ovarian Carcinoma	GDSC	PVTPEPT	DEG_SCF_FBW7_1	1546:1552	Mutation rewiring degron network	0.1667
p.G1558D	IGROV-1	ovary	COSMIC	PVTPEPT	DEG_SCF_FBW7_1	1546:1552	Mutation rewiring degron network	0.1667
p.T1355K	SIDM01056	Breast Carcinoma	GDSC	PVTPKPT	DEG_SCF_FBW7_1	1341:1347	Mutation rewiring degron network	0.1111
p.T1355K	EFM-19	breast	COSMIC	PVTPKPT	DEG_SCF_FBW7_1	1341:1347	Mutation rewiring degron network	0.1111
p.T1183I	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.0833
p.T1183I	ACH-000917	Esophageal Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.0833
p.T1183I	TE-4	oesophagus	COSMIC	PSTST	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.0833
p.S1225F	SIDM00221	Melanoma	GDSC	PSTST	DEG_SPOP_SBC_1	1211:1215	Mutation rewiring degron network	0.0556
p.A1134V	SIDM00126	Melanoma	GDSC	PVTPKPT	DEG_SCF_FBW7_1	1136:1142	Mutation rewiring degron network	0.2778
p.A1134V	SIDM00126	Melanoma	GDSC	PSTST	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.3056
p.A1134V	ACH-002147	Skin Cancer	CCLE	PVTPKPT	DEG_SCF_FBW7_1	1136:1142	Mutation rewiring degron network	0.2778
p.A1134V	ACH-002147	Skin Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.3056
p.A1134V	K2	skin	COSMIC	PVTPKPT	DEG_SCF_FBW7_1	1136:1142	Mutation rewiring degron network	0.2778
p.A1134V	K2	skin	COSMIC	PSTST	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.3056
p.S1583C	SIDM00920	Breast Carcinoma	GDSC	LVTPEPT	DEG_SCF_FBW7_1	1587:1593	Mutation rewiring degron network	0.2222
p.S1583C	ACH-000783	Breast Cancer	CCLE	LVTPEPT	DEG_SCF_FBW7_1	1587:1593	Mutation rewiring degron network	0.2222
p.S1583C	CAMA-1	breast	COSMIC	LVTPEPT	DEG_SCF_FBW7_1	1587:1593	Mutation rewiring degron network	0.2222
p.A1534T	SIDM00217	Colorectal Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	1539:1543	Mutation rewiring degron network	0.1944
p.A1534T	ACH-000999	Colon/Colorectal Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	1539:1543	Mutation rewiring degron network	0.1944
p.A1534T	SNU-1040	large intestine	COSMIC	PSTST	DEG_SPOP_SBC_1	1539:1543	Mutation rewiring degron network	0.1944
p.S1594Y	SIDM00534	Colorectal Carcinoma	GDSC	LVTPEPT	DEG_SCF_FBW7_1	1587:1593	Mutation rewiring degron network	0.3056
p.S1594Y	ACH-000986	Colon/Colorectal Cancer	CCLE	LVTPEPT	DEG_SCF_FBW7_1	1587:1593	Mutation rewiring degron network	0.3056
p.S1594Y	HT-115	large intestine	COSMIC	LVTPEPT	DEG_SCF_FBW7_1	1587:1593	Mutation rewiring degron network	0.3056
p.T1615I	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	TPEPVVPTA	DEG_COP1_1	1608:1616	Mutation altering degron motif	0.7078
p.T1615I	ACH-001498	Lymphoma	CCLE	TPEPVVPTA	DEG_COP1_1	1608:1616	Mutation altering degron motif	0.7078
p.T1615I	Farage	haematopoietic and lymphoid tissue	COSMIC	TPEPVVPTA	DEG_COP1_1	1608:1616	Mutation altering degron motif	0.7078
p.R1644S	SIDM01173	Rhabdomyosarcoma	GDSC	PVTPKLT	DEG_SCF_FBW7_1	1628:1634	Mutation rewiring degron network	0.0556
p.R1644S	SIDM01318	Hepatocellular Carcinoma	GDSC	PVTPKLT	DEG_SCF_FBW7_1	1628:1634	Mutation rewiring degron network	0.0556
p.R1644S	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PVTPKLT	DEG_SCF_FBW7_1	1628:1634	Mutation rewiring degron network	0.0556
p.P1166S	SIDM01503	Small Cell Lung Carcinoma	GDSC	TPEPVVPTA	DEG_COP1_1	1157:1165	Mutation rewiring degron network	0.3056
p.P1166S	SIDM01503	Small Cell Lung Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.2222
p.P1166S	ACH-000844	Lung Cancer	CCLE	TPEPVVPTA	DEG_COP1_1	1157:1165	Mutation rewiring degron network	0.3056
p.P1166S	ACH-000844	Lung Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.2222
p.P1341T	SIDM01526	Mesothelioma	GDSC	PVTPKPT	DEG_SCF_FBW7_1	1341:1347	Mutation altering degron motif	0.7031
p.S1148N	SIDM01611	Endometrial Carcinoma	GDSC	TPEPVVPTA	DEG_COP1_1	1157:1165	Mutation rewiring degron network	0.0833
p.S1148N	SIDM01611	Endometrial Carcinoma	GDSC	PVTPKPT	DEG_SCF_FBW7_1	1136:1142	Mutation rewiring degron network	0.1667
p.S1148N	ACH-000996	Endometrial/Uterine Cancer	CCLE	TPEPVVPTA	DEG_COP1_1	1157:1165	Mutation rewiring degron network	0.0833
p.S1148N	ACH-000996	Endometrial/Uterine Cancer	CCLE	PVTPKPT	DEG_SCF_FBW7_1	1136:1142	Mutation rewiring degron network	0.1667
p.P1426S	SIDM01768	Melanoma	GDSC	PVTPEPT	DEG_SCF_FBW7_1	1423:1429	Mutation altering degron motif	0.6752
p.P1426S	ACH-000899	Skin Cancer	CCLE	PVTPEPT	DEG_SCF_FBW7_1	1423:1429	Mutation altering degron motif	0.6752
p.N644H	SIDM01588	Endometrial Carcinoma	GDSC	SRENLTDLV	DEG_APCC_DBOX_1	641:649	Mutation altering degron motif	0.6312
p.N644H	ACH-000993	Endometrial/Uterine Cancer	CCLE	SRENLTDLV	DEG_APCC_DBOX_1	641:649	Mutation altering degron motif	0.6312
p.L1250F	ACH-001210	Rhabdoid	CCLE	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.25
p.L1250F	ACH-001210	Rhabdoid	CCLE	PSTST	DEG_SPOP_SBC_1	1252:1256	Mutation rewiring degron network	0.2778
p.R1557K	ACH-001366	Neuroblastoma	CCLE	PVTPEPT	DEG_SCF_FBW7_1	1546:1552	Mutation rewiring degron network	0.1944
p.S1378F	ACH-001554	Eye Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	1374:1378	Mutation altering degron motif	0.7982
p.P1129S	ACH-001569	Skin Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	1129:1133	Mutation altering degron motif	0.6752
p.T1589N	ACH-001853	Bile Duct Cancer	CCLE	LVTPEPT	DEG_SCF_FBW7_1	1587:1593	Mutation altering degron motif	0.8166
p.E1618K	ACH-002019	Cervical Cancer	CCLE	TPEPVVPTA	DEG_COP1_1	1608:1616	Mutation rewiring degron network	0.2778
p.E1618K	ACH-002019	Cervical Cancer	CCLE	PVTPKLT	DEG_SCF_FBW7_1	1628:1634	Mutation rewiring degron network	0.0556
p.E1618K	ACH-002019	Cervical Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	1621:1625	Mutation rewiring degron network	0.25
p.E1536K	ACH-002019	Cervical Cancer	CCLE	PVTPEPT	DEG_SCF_FBW7_1	1546:1552	Mutation rewiring degron network	0.0556
p.E1536K	ACH-002019	Cervical Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	1539:1543	Mutation rewiring degron network	0.25
p.V1408L	ACH-002019	Cervical Cancer	CCLE	TPETLVPTA	DEG_COP1_1	1403:1411	Mutation altering degron motif	0.6765
p.E1380K	ACH-002019	Cervical Cancer	CCLE	PVTPEPT	DEG_SCF_FBW7_1	1382:1388	Mutation rewiring degron network	0.2778
p.E1380K	ACH-002019	Cervical Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	1374:1378	Mutation rewiring degron network	0.2778
p.N1233S	NCI-H1734	lung	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	DBTRG-05MG	central nervous system	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	MDA-MB-157	breast	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	GRANTA-519	haematopoietic and lymphoid tissue	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	CAL-85-1	breast	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	BC-3	haematopoietic and lymphoid tissue	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	DG-75	haematopoietic and lymphoid tissue	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	ALL-PO	haematopoietic and lymphoid tissue	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	KLE	endometrium	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	EMC-BAC-1	lung	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	MHH-ES-1	bone	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	ESO26	oesophagus	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	SCaBER	urinary tract	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	GA-10	haematopoietic and lymphoid tissue	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	HPAF-II	pancreas	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	BT-483	breast	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	REH	haematopoietic and lymphoid tissue	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	U251	central nervous system	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	NCI-H23	lung	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	H2810	pleura	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	A431	skin	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	NCI-H835	lung	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	NCI-H1694	lung	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.N1233S	NCI-H1105	lung	COSMIC	TPEPVVPTA	DEG_COP1_1	1239:1247	Mutation rewiring degron network	0.1667
p.Q1176R	NCI-H23	lung	COSMIC	PSTST	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.2778
p.Q1176R	U251	central nervous system	COSMIC	PSTST	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.2778
p.Q1176R	NCI-H1734	lung	COSMIC	PSTST	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.2778
p.Q1176R	A431	skin	COSMIC	PSTST	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.2778
p.Q1176R	NCI-H1694	lung	COSMIC	PSTST	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MDC1

UniProt ID: Q14676

Entrez ID: 9656

Protein name: Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MDC1 in