DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_SCF_FBW7_1

Location: 1628:1634

E3 ligase: FBXW7

DEGRON score: 0.9985

ASA_SCORE: 103.4286

COIL: 0.9647

CONS_SCORE: 0.3635

DSS_SCORE: 0.7676

HELIX: 0.0147

FCONS_SCORE: 1.1938

RIG_SCORE: 0.6862

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1634I	TCGA-EC-A1QX	UCEC	TCGA	PVTPKLT	DEG_SCF_FBW7_1	0.7078
p.P1628L	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PVTPKLT	DEG_SCF_FBW7_1	0.6471
p.P1628L	ACH-000823	Esophageal Cancer	CCLE	PVTPKLT	DEG_SCF_FBW7_1	0.6471
p.P1628L	KYSE-140	oesophagus	COSMIC	PVTPKLT	DEG_SCF_FBW7_1	0.6471
p.R1644M	TCGA-VQ-A8P2	STAD	TCGA	PVTPKLT	DEG_SCF_FBW7_1	0.0556
p.R1644S	SIDM01173	Rhabdomyosarcoma	GDSC	PVTPKLT	DEG_SCF_FBW7_1	0.0556
p.R1644S	SIDM01318	Hepatocellular Carcinoma	GDSC	PVTPKLT	DEG_SCF_FBW7_1	0.0556
p.R1644S	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PVTPKLT	DEG_SCF_FBW7_1	0.0556
p.E1618K	ACH-002019	Cervical Cancer	CCLE	PVTPKLT	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1628:1634	PVTPKLT	FBXW7	0.9985	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons