DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PVTPKLT
Uniprot ID:
Q14676
Source protein:
Mediator of DNA damage checkpoint protein 1
Source gene:
MDC1
Class:
DEG_SCF_FBW7_1
Location:
1628:1634
E3 ligase:
FBXW7
DEGRON score:
0.9985
ASA_SCORE:
103.4286
COIL:
0.9647
CONS_SCORE:
0.3635
DSS_SCORE:
0.7676
HELIX:
0.0147
FCONS_SCORE:
1.1938
RIG_SCORE:
0.6862
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T1634I
TCGA-EC-A1QX
UCEC
TCGA
PVTPKLT
DEG_SCF_FBW7_1
0.7078
p.R1644M
TCGA-VQ-A8P2
STAD
TCGA
PVTPKLT
DEG_SCF_FBW7_1
0.0556
p.P1628L
SIDM01032
Esophageal Squamous Cell Carcinoma
GDSC
PVTPKLT
DEG_SCF_FBW7_1
0.6471
p.P1628L
ACH-000823
Esophageal Cancer
CCLE
PVTPKLT
DEG_SCF_FBW7_1
0.6471
p.P1628L
KYSE-140
oesophagus
COSMIC
PVTPKLT
DEG_SCF_FBW7_1
0.6471
p.R1644S
SIDM01173
Rhabdomyosarcoma
GDSC
PVTPKLT
DEG_SCF_FBW7_1
0.0556
p.R1644S
SIDM01318
Hepatocellular Carcinoma
GDSC
PVTPKLT
DEG_SCF_FBW7_1
0.0556
p.R1644S
SIDM01686
Chronic Myelogenous Leukemia
GDSC
PVTPKLT
DEG_SCF_FBW7_1
0.0556
p.E1618K
ACH-002019
Cervical Cancer
CCLE
PVTPKLT
DEG_SCF_FBW7_1
0.0556
Drug responses associated with MDC1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PVTPKLT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q14676
Mediator of DNA damage checkpoint protein 1
DEG_SCF_FBW7_1
1628:1634
PVTPKLT
FBXW7
0.9985
More...