DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_SCF_FBW7_1

Location: 1587:1593

E3 ligase: FBXW7

DEGRON score: 0.9905

ASA_SCORE: 100.5

COIL: 0.9481

CONS_SCORE: 0.2657

DSS_SCORE: 0.7089

HELIX: 0.0144

FCONS_SCORE: 0.9858

RIG_SCORE: 0.6709

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1590T	TCGA-AP-A051	UCEC	TCGA	LVTPEPT	DEG_SCF_FBW7_1	0.7031
p.R1603W	TCGA-DD-AAE2	LIHC	TCGA	LVTPEPT	DEG_SCF_FBW7_1	0.0556
p.R1595W	TCGA-DS-A1OB	CESC	TCGA	LVTPEPT	DEG_SCF_FBW7_1	0.2778
p.R1595W	SIDM00128	Head and Neck Carcinoma	GDSC	LVTPEPT	DEG_SCF_FBW7_1	0.2778
p.R1595W	ACH-002249	Head and Neck Cancer	CCLE	LVTPEPT	DEG_SCF_FBW7_1	0.2778
p.R1595W	JHU-011	upper_aerodigestive_tract	COSMIC	LVTPEPT	DEG_SCF_FBW7_1	0.2778
p.S1583C	SIDM00920	Breast Carcinoma	GDSC	LVTPEPT	DEG_SCF_FBW7_1	0.2222
p.S1583C	ACH-000783	Breast Cancer	CCLE	LVTPEPT	DEG_SCF_FBW7_1	0.2222
p.S1583C	CAMA-1	breast	COSMIC	LVTPEPT	DEG_SCF_FBW7_1	0.2222
p.S1594Y	SIDM00534	Colorectal Carcinoma	GDSC	LVTPEPT	DEG_SCF_FBW7_1	0.3056
p.S1594Y	ACH-000986	Colon/Colorectal Cancer	CCLE	LVTPEPT	DEG_SCF_FBW7_1	0.3056
p.S1594Y	HT-115	large_intestine	COSMIC	LVTPEPT	DEG_SCF_FBW7_1	0.3056
p.T1589N	ACH-001853	Bile Duct Cancer	CCLE	LVTPEPT	DEG_SCF_FBW7_1	0.8166

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1587:1593	LVTPEPT	FBXW7	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons