DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_APCC_DBOX_1

Location: 641:649

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8155

ASA_SCORE: 95.4

COIL: 0.7463

CONS_SCORE: 0.2913

DSS_SCORE: 0.5617

HELIX: 0.1679

FCONS_SCORE: 0.8827

RIG_SCORE: 0.7686

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L645I	TCGA-CD-A4MG	STAD	TCGA	SRENLTDLV	DEG_APCC_DBOX_1	0.7174
p.L645I	DO48009	STAD	ICGC	SRENLTDLV	DEG_APCC_DBOX_1	0.7174
p.P639L	TCGA-WS-AB45	COAD	TCGA	SRENLTDLV	DEG_APCC_DBOX_1	0.2778
p.P639L	DO51734	COAD	ICGC	SRENLTDLV	DEG_APCC_DBOX_1	0.2778
p.P639L	DO233634	GACA	ICGC	SRENLTDLV	DEG_APCC_DBOX_1	0.2778
p.E643Q	DO233777	GACA	ICGC	SRENLTDLV	DEG_APCC_DBOX_1	0.5633
p.L655I	DO233942	GACA	ICGC	SRENLTDLV	DEG_APCC_DBOX_1	0.1667
p.A632S	DO50718	ORCA	ICGC	SRENLTDLV	DEG_APCC_DBOX_1	0.0833
p.L648M	SIDM00255	Neuroblastoma	GDSC	SRENLTDLV	DEG_APCC_DBOX_1	0.5999
p.L648M	ACH-002282	Neuroblastoma	CCLE	SRENLTDLV	DEG_APCC_DBOX_1	0.5999
p.L648M	NB17	autonomic_ganglia	COSMIC	SRENLTDLV	DEG_APCC_DBOX_1	0.5999
p.N644H	SIDM01588	Endometrial Carcinoma	GDSC	SRENLTDLV	DEG_APCC_DBOX_1	0.6312
p.N644H	ACH-000993	Endometrial/Uterine Cancer	CCLE	SRENLTDLV	DEG_APCC_DBOX_1	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_APCC_DBOX_1	641:649	SRENLTDLV	APC,CDC20,FZR1	0.8155	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons