DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_COP1_1

Location: 1403:1411

E3 ligase: COP1

DEGRON score: 0.9714

ASA_SCORE: 98.9667

COIL: 0.9536

CONS_SCORE: 0.3516

DSS_SCORE: 0.7823

HELIX: 0.0132

FCONS_SCORE: 0.9767

RIG_SCORE: 0.6371

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1415K	TCGA-AG-A002	READ	TCGA	TPETLVPTA	DEG_COP1_1	0.2222
p.G1401C	TCGA-CN-6010	HNSC	TCGA	TPETLVPTA	DEG_COP1_1	0.2778
p.N1397H	TCGA-D1-A16Y	UCEC	TCGA	TPETLVPTA	DEG_COP1_1	0.1667
p.R1395I	TCGA-F5-6814	READ	TCGA	TPETLVPTA	DEG_COP1_1	0.1111
p.N1397I	TCGA-F7-A61S	HNSC	TCGA	TPETLVPTA	DEG_COP1_1	0.1667
p.T1400S	DO228483	BRCA	ICGC	TPETLVPTA	DEG_COP1_1	0.6944
p.T1400S	DO230659	LAML	ICGC	TPETLVPTA	DEG_COP1_1	0.6944
p.T1400S	DO231140	LAML	ICGC	TPETLVPTA	DEG_COP1_1	0.6944
p.L1396F	DO2198	BRCA	ICGC	TPETLVPTA	DEG_COP1_1	0.25
p.S1394F	DO49976	CESC	ICGC	TPETLVPTA	DEG_COP1_1	0.0833
p.V1406I	DO47925	STAD	ICGC	TPETLVPTA	DEG_COP1_1	0.7076
p.V1408L	ACH-002019	Cervical Cancer	CCLE	TPETLVPTA	DEG_COP1_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1403:1411	TPETLVPTA	COP1	0.9714	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons