DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_SPOP_SBC_1

Location: 1129:1133

E3 ligase: SPOP

DEGRON score: 0.9421

ASA_SCORE: 93.08

COIL: 0.9576

CONS_SCORE: 0.2951

DSS_SCORE: 0.7985

HELIX: 0.0184

FCONS_SCORE: 0.9515

RIG_SCORE: 0.5363

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1119T	TCGA-17-Z026	LUAD	TCGA	PSTST	DEG_SPOP_SBC_1	0.0556
p.S1132C	TCGA-A5-A1OH	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	0.7541
p.S1143Y	TCGA-AX-A2HC	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	0.0556
p.P1127L	TCGA-W3-AA1V	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	0.2778
p.R1126W	DO9514	COAD	ICGC	PSTST	DEG_SPOP_SBC_1	0.25
p.R1134I	DO233754	GACA	ICGC	PSTST	DEG_SPOP_SBC_1	0.3056
p.N1133I	DO44427	HNSC	ICGC	PSTST	DEG_SPOP_SBC_1	0.728
p.R1131I	DO36556	READ	ICGC	PSTST	DEG_SPOP_SBC_1	0.8102
p.R1126Q	DO51784	STAD	ICGC	PSTST	DEG_SPOP_SBC_1	0.25
p.S1125Y	DO41133	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	0.2222
p.S1125Y	DO42713	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	0.2222
p.N1133H	DO41524	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	0.7423
p.A1124D	SIDM00142	Endometrial Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	0.1944
p.A1124D	ACH-000864	Endometrial/Uterine Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	0.1944
p.A1124D	COLO-684	endometrium	COSMIC	PSTST	DEG_SPOP_SBC_1	0.1944
p.A1134V	SIDM00126	Melanoma	GDSC	PSTST	DEG_SPOP_SBC_1	0.3056
p.A1134V	ACH-002147	Skin Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	0.3056
p.A1134V	K2	skin	COSMIC	PSTST	DEG_SPOP_SBC_1	0.3056
p.P1129S	ACH-001569	Skin Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	966:970	PSTST	SPOP	0.9963	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	1809:1813	PSTST	SPOP	0.9674	More...
P18583	Protein SON	DEG_SPOP_SBC_1	320:324	PSTST	SPOP	0.9507	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	432:436	PSTST	SPOP	0.9333	More...
Q00056	Homeobox protein Hox-A4	DEG_SPOP_SBC_1	310:314	PSTST	SPOP	0.9405	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	1351:1355	PSTST	SPOP	0.9777	More...
Q14209	Transcription factor E2F2	DEG_SPOP_SBC_1	319:323	PSTST	SPOP	0.8702	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1129:1133	PSTST	SPOP	0.9421	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1170:1174	PSTST	SPOP	0.9246	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1211:1215	PSTST	SPOP	0.9576	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1252:1256	PSTST	SPOP	0.941	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1293:1297	PSTST	SPOP	0.8982	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1416:1420	PSTST	SPOP	0.9919	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1457:1461	PSTST	SPOP	0.7823	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1539:1543	PSTST	SPOP	0.9907	More...
Q5JQC9	A-kinase anchor protein 4	DEG_SPOP_SBC_1	131:135	PSTST	SPOP	0.6428	More...
Q7Z3K3	Pogo transposable element with ZNF domain	DEG_SPOP_SBC_1	253:257	PSTST	SPOP	0.9085	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6882:6886	PSTST	SPOP	0.8449	More...
Q92546	RAB6A-GEF complex partner protein 2	DEG_SPOP_SBC_1	384:388	PSTST	SPOP	0.9331	More...
Q96EP1	E3 ubiquitin-protein ligase CHFR	DEG_SPOP_SBC_1	177:181	PSTST	SPOP	0.9967	More...
Q96G42	Kelch domain-containing protein 7B	DEG_SPOP_SBC_1	29:33	PSTST	SPOP	0.9278	More...
Q96PD2	Discoidin, CUB and LCCL domain-containing protein 2	DEG_SPOP_SBC_1	696:700	PSTST	SPOP	0.9984	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	506:510	PSTST	SPOP	0.6935	More...
Q99715	Collagen alpha-1	DEG_SPOP_SBC_1	1855:1859	PSTST	SPOP	0.7973	More...
Q99856	AT-rich interactive domain-containing protein 3A	DEG_SPOP_SBC_1	583:587	PSTST	SPOP	0.9473	More...
Q9BZF3	Oxysterol-binding protein-related protein 6	DEG_SPOP_SBC_1	200:204	PSTST	SPOP	0.9954	More...
Q9P2P6	StAR-related lipid transfer protein 9	DEG_SPOP_SBC_1	1859:1863	PSTST	SPOP	0.8119	More...
Q9P2R6	Arginine-glutamic acid dipeptide repeats protein	DEG_SPOP_SBC_1	1053:1057	PSTST	SPOP	0.8236	More...
Q9UBT2	SUMO-activating enzyme subunit 2	DEG_SPOP_SBC_1	576:580	PSTST	SPOP	0.891	More...
Q9UBU7	Protein DBF4 homolog A	DEG_SPOP_SBC_1	666:670	PSTST	SPOP	0.6306	More...
Q9ULU4	Protein kinase C-binding protein 1	DEG_SPOP_SBC_1	879:883	PSTST	SPOP	0.9313	More...
Q5T1B0	Axonemal dynein light chain domain-containing protein 1	DEG_SPOP_SBC_1	872:876	PSTST	SPOP	0.9934	More...
Q6PI47	BTB/POZ domain-containing protein KCTD18	DEG_SPOP_SBC_1	281:285	PSTST	SPOP	0.6017	More...
Q8N5C6	S1 RNA-binding domain-containing protein 1	DEG_SPOP_SBC_1	155:159	PSTST	SPOP	0.9948	More...
Q8TC56	Golgi associated RAB2 interactor protein 3	DEG_SPOP_SBC_1	250:254	PSTST	SPOP	0.9921	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTST

Degron related mutations and impact score

Drug responses associated with MDC1 mutations

All proteins holding degron of PSTST