DegronMD - Q00056(HOXA4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L304I	TCGA-AX-A2HD	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1667
p.L304I	DO42608	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1667
p.P306S	TCGA-BC-A10R	LIHC	TCGA	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.2222
p.P306S	DO22962	LIHC	ICGC	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.2222
p.H305Q	TCGA-BC-A10R	LIHC	TCGA	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1944
p.H305Q	DO22962	LIHC	ICGC	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1944
p.S318F	TCGA-D8-A1XJ	BRCA	TCGA	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.2222
p.S318F	DO5611	BRCA	ICGC	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.2222
p.S319F	TCGA-EE-A2MS	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1944
p.S319F	DO37567	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1944
p.S319F	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1944
p.S319F	ACH-000983	Leukemia	CCLE	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1944
p.S319F	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1944
p.Y23H	TCGA-F7-A624	HNSC	TCGA	FPPFEE	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.3056
p.Y23H	DO230312	COCA	ICGC	FPPFEE	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.3056
p.Y23H	DO44440	HNSC	ICGC	FPPFEE	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.3056
p.P302S	TCGA-FR-A729	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1111
p.P302S	DO48618	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1111
p.L7S	TCGA-NI-A8LF	LIHC	TCGA	FPPFEE	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.0556
p.L7S	DO49715	LIHC	ICGC	FPPFEE	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.0556
p.H307Q	DO229019	LICA	ICGC	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.25
p.G31A	DO231631	LINC	ICGC	FPPFEE	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.0833
p.Y23C	DO34120	PACA	ICGC	FPPFEE	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.3056
p.H309N	SIDM01722	Non-Cancerous	GDSC	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.3056
p.H309N	SIDM00174	Head and Neck Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.3056
p.H309N	SIDM00941	Kidney Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.3056
p.H309N	CAKI-1	kidney	COSMIC	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.3056
p.V316I	SIDM00391	Plasma Cell Myeloma	GDSC	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.2778
p.V316I	SIDM00220	Ovarian Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.2778
p.V316I	ACH-000363	Myeloma	CCLE	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.2778
p.V316I	ACH-000962	Ovarian Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.2778
p.V316I	ACH-001145	Ovarian Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.2778
p.V316I	SK-MM-2	haematopoietic and lymphoid tissue	COSMIC	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.2778
p.V316I	OC-314	ovary	COSMIC	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.2778
p.H307P	NBsusSR	autonomic ganglia	COSMIC	PSTST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.25

Kaplan plot for HOXA4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HOXA4

UniProt ID: Q00056

Entrez ID: 3201

Protein name: Homeobox protein Hox-A4 (Homeobox protein Hox-1.4) (Homeobox protein Hox-1D)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HOXA4 in